Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis

Silverwood, Victoria; Blagojevic‐Bucknall, Milica; Jinks, Clare; Jordan, Joanne L.; Protheroe, Joanne; Jordan, Kelvin

doi:10.1016/j.joca.2014.11.019

Cited by 737 publications

(628 citation statements)

References 52 publications

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“…In addition, metabolic factors (hypertension, type 2 diabetes mellitus, impaired fasting glucose [IFG], dyslipidemia, and lipid‐lowering drugs) and nodal OA, which have been implicated in OA etiology at other joints, were investigated 19, 20, 21, 22. Demographic data (age, sex, occupation), along with the presence of hip pain and knee pain in the last year, wearing of high‐heeled and narrow‐toed footwear between the ages of 20 and 49 years, 12, and intermittent claudication determined from the Edinburgh Claudication Questionnaire 23, were collected in the health survey questionnaire.…”

Section: Methodsmentioning

confidence: 99%

Investigations of Potential Phenotypes of Foot Osteoarthritis: Cross‐Sectional Analysis From the Clinical Assessment Study of the Foot

Rathod

Marshall

Thomas

et al. 2016

Arthritis Care & Research

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ObjectiveTo investigate the existence of distinct foot osteoarthritis (OA) phenotypes based on pattern of joint involvement and comparative symptom and risk profiles.MethodsParticipants ages ≥50 years reporting foot pain in the previous year were drawn from a population‐based cohort. Radiographs were scored for OA in the first metatarsophalangeal (MTP) joint, first and second cuneometatarsal, navicular first cuneiform, and talonavicular joints according to a published atlas. Chi‐square tests established clustering, and odds ratios (ORs) examined symmetry and pairwise associations of radiographic OA in the feet. Distinct underlying classes of foot OA were investigated by latent class analysis (LCA) and their association with symptoms and risk factors was assessed.ResultsIn 533 participants (mean age 64.9 years, 55.9% female) radiographic OA clustered across both feet (P < 0.001) and was highly symmetrical (adjusted OR 3.0, 95% confidence interval 2.1, 4.2). LCA identified 3 distinct classes of foot OA: no or minimal foot OA (64%), isolated first MTP joint OA (22%), and polyarticular foot OA (15%). After adjustment for age and sex, polyarticular foot OA was associated with nodal OA, increased body mass index, and more pain and functional limitation compared to the other classes.ConclusionPatterning of radiographic foot OA has provided insight into the existence of 2 forms of foot OA: isolated first MTP joint OA and polyarticular foot OA. The symptom and risk factor profiles in individuals with polyarticular foot OA indicate a possible distinctive phenotype of foot OA, but further research is needed to explore the characteristics of isolated first MTP joint and polyarticular foot OA.

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Section: Methodsmentioning

confidence: 99%

Investigations of Potential Phenotypes of Foot Osteoarthritis: Cross‐Sectional Analysis From the Clinical Assessment Study of the Foot

Rathod

Marshall

Thomas

et al. 2016

Arthritis Care & Research

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“…10 All participants in this study are accidentally women, which is concomittant with the epidemiology data that women have a higher risk of developing OA compared to men. 7 The BMI mean for subjects in this study was 27.34 kg/m 2 with the lowest BMI of 16.01 kg/m 2 and the highest BMI was 37.65 kg/m 2 . Most subjects in this study was overweight (66.67%).…”

Section: Discussionmentioning

confidence: 57%

“…Knee OA risk is increasing in women after menopause due to hormonal fluctuations, sedentary lifestyle, and fat-rich food consumption that contribute to weight gain. 7 Weight loss in patients with knee OA should be managed through an exercise regimen in order to restore or increase the muscle mass.…”

Section: Introductionmentioning

confidence: 99%

Effects of Quadriceps Strengthening Exercise on Quadriceps Muscle Strength and Its Relation to Lower Extremity Lean Mass

Desiana¹,

Moeliono²,

Prabowo³

2017

IJIHS

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Objective: To discover whether quadriceps resistance exercise could increase quadriceps strength as well as its relation to lower extremity lean mass. Methods:This study was a pre-and post-experimental study in which 36 participants with knee OA grade 2 and 3 were recruited. Assesment of leg lean mass and quadriceps strength was taken before and after intervention. Participants practiced quadriceps isotonic resistance exercise 3 times a week for 8 weeks. This study was conducted in Dr. Hasan Sadikin General Hospital, Bandung from September 2014 to February 2015.Results: After the intervention, an increase in quadriceps strength was seen but not in the lower extremity lean mass. Statistical analysis showed that there was no correlation between lower extremity lean mass and quadriceps strength. Conclusions:Quadriceps strength is found to increase after intervention. No increase is found in the lower extremity lean mass.

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“…PAF for other countries ranged from 43% for Australia to 8% for China, depending on obesity prevalence. Silverwood et al (27) estimated PAF for knee OA in the UK at 25%, whereas Kearns et al (28) found PAF for any OA in Ireland to be 20%. Estimates of PAF may vary due to differences in the relative risk of OA for a unit change in BMI across published studies.…”

Section: Discussionmentioning

confidence: 99%

Effects of Reductions in Body Mass Index on the Future Osteoarthritis Burden in Canada: A Population‐Based Microsimulation Study

Kopeć

Sayre

Finès

et al. 2016

Arthritis Care & Research

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Objective. Osteoarthritis (OA) is the most common joint disease and a major cause of disability. Incidence and prevalence of OA are expected to increase due to population aging and increased levels of obesity. The purpose of this study was to project the effect of hypothetical interventions that change the distribution of body mass index (BMI) on OA burden in Canada. Methods. We used a microsimulation computer model of OA based on the Population Health Model platform. The model used demographic predictions for Canada and population data from an administrative database in British Columbia and national Canadian surveys.Results. Under the base-case scenario, between 2010 and 2030, OA prevalence is expected to increase from 11.5% to 15.6% in men and 16.3% to 21.1% in women. In scenarios assuming, on average, a 0.3-, 0.5-, or 1-unit drop in BMI per year, OA prevalence in 2030 would reach 14.9%, 14.6%, and 14.2% in men and 20.3%, 19.7%, and 18.5%, in women, respectively. Under these scenarios, the proportion of new cases prevented would be 9.5%, 13.2%, and 16.7%, respectively, in men, and 9.1%, 15.2%, and 25.0% in women. Targeting only those people ages ‡50 years for weight reduction would achieve approximately 70% of the impact of a full population strategy. Targeting only the obese (BMI ‡30) would likely result in a larger benefit for men than women. Conclusion. Due to the aging of the population, OA will remain a major and growing health issue in Canada over the next 2 decades, regardless of the course of the obesity epidemic.

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Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis

Cited by 737 publications

References 52 publications

Investigations of Potential Phenotypes of Foot Osteoarthritis: Cross‐Sectional Analysis From the Clinical Assessment Study of the Foot

Investigations of Potential Phenotypes of Foot Osteoarthritis: Cross‐Sectional Analysis From the Clinical Assessment Study of the Foot

Effects of Quadriceps Strengthening Exercise on Quadriceps Muscle Strength and Its Relation to Lower Extremity Lean Mass

Effects of Reductions in Body Mass Index on the Future Osteoarthritis Burden in Canada: A Population‐Based Microsimulation Study

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