Current evidence on the management of hepatitis B in pregnancy

Maraolo, Alberto Enrico; Gentile, Ivan; Buonomo, Antonio Riccardo; Pinchera, Biagio; Borgia, Guglielmo

doi:10.4254/wjh.v10.i9.585

Cited by 8 publications

(4 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the United States, HBV testing is part of regular prenatal treatment, and children born to HBsAg-positive mothers get HBV immune globulin and vaccination to prevent transmission 16,17 .…”

Section: Discussionmentioning

confidence: 99%

A Large Data Set; Hepatitis B and C Infection in Pregnant Females

Zafar¹,

Javed²,

Naveed³

et al. 2022

PJMHS

View full text Add to dashboard Cite

Background: Hepatitis B and C virus (HBV & HCV) infection is on the surge among pregnant women as a result of unsaved dental and cosmetic procedures, reuse of needles, raising the risk of perinatal transmission and HBV & HCV infection in children. Although few studies on the prevalence of HBV and HCV infection during pregnancy have been conducted but the majority of the studies are on very low sample size. The current study is based on large data set. Objectives: The major goal of this study was to find out the frequency of HBV & HCV in pregnant women. Methods: We conducted a retrospective cohort study in Alkhidmat Raazi Hospital Rawalpindi. A total of 31911 pregnant women who delivered between 2016 and 2021 were analyzed and categorized as HBV & HCV infected or HBV & HCV uninfected by billing codes. The birth certificate and hospital discharge records were used to identify infant records related to HBV and HCV-infected pregnant mothers. Pregnant women's plasma samples were tested for HBV and HCV using chemiluminescence ARCHITECT i1000SR® Abbott Diagnostics. Data were analyzed using packages within SPSS software and P ≤ 0.05 was considered significant. Cross-tabulation chi-square analysis was performed with a significance level of 5%. Results: The pregnant women with age under 25 years were 12699 (39.8%), women with age from 26 to 29 years were 9734 (30.5%), while women with age 30 and older were 9478 (29.7). The patients who were primigravida were 9514 (29.8%), multipara having 1-4 children 18545 (58.1%) and those having more than five children were 3852 (12.1%). The prevalence of HBV and HCV in 31911 pregnant women were 170/31911 (0.5%) and 478/31911 (1.5%), respectively. The mean age was 27.9 years. Conclusions: HBV and HCV infection is present in pregnant females, which may ultimately increase the treatment cost and vertical transmission. Keywords: Hepatitis B, Hepatitis C, Infection, Pregnant females

show abstract

Section: Discussionmentioning

confidence: 99%

A Large Data Set; Hepatitis B and C Infection in Pregnant Females

Zafar¹,

Javed²,

Naveed³

et al. 2022

PJMHS

View full text Add to dashboard Cite

show abstract

“…This risk is much higher than from horizontal transmission where the rate of chronicity is 30± 50% when infected before 6 years of age and <5% when infected in adulthood [1][2][3] . Despite improved childhood HBV vaccination worldwide, MTCT still accounts for about 50% of new HBV infections in high endemic countries and one-third in low endemic countries [4][5][6][7] . Therefore, preventing MTCT is crucial for decreasing HBV prevalence.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude and Practices Regarding Hepatitis B among Expectant Mothers Seeking Antenatal Care in a Tertiary Care Hospital in a Metropolitan City

Rachhanaa Pawaskar,

Deepika Sadawarte

2023

IJPHRD

View full text Add to dashboard Cite

Background: Mother-to-child-transmission (MTCT) is one of the common modes of Hepatitis B transmission. Though there is improved childhood Hepatitis B vaccination in India, MTCT accounts for about 50% of new Hepatitis B infection. Preventing MTCT is of utmost importance for decreasing the feet of Hepatitis B. Prevention requires expectant mothers to be aware of the disease and to understand the consequences of Hepatitis B transmission to their child. The study aimed to determine the knowledge, attitude and practice (KAP) towards Hepatitis B among the expectant mothers seeking antenatal care in a tertiary hospital in a metropolitan city.Methods: After obtaining Ethics clearance from the Institutional Ethics Committee, this cross sectional study was conducted among 163 expectant women attending the outpatient and inpatient department of Obstetrics and Gynecology of a tertiary care centre. Data collection was done using a study questionnaire and analysis was done using IBM SPSS version 26.0 Results: Forty nine percent of the 163 participants were aware about hepatitis B infection. Only 7% were aware of mother to child transmission. Socio-demographic factors like age, education, socioeconomic status were statistically significantly associated with awareness regarding Hepatitis B, but the gravid status was not. None of the women were aware of the National Viral Hepatitis Control Program (NVHCP) launched by the Government of India and its provisions. Conclusions:The need for creating awareness regarding Hepatitis B among expectant mothers exists, since a substantial number of females lack knowledge and positive attitude which reflects as poor practices towards Hepatitis B.

show abstract

“…In areas with a high HVB prevalence, MTCT is the primary source of infection. MTCT occurs most commonly around the time of delivery but may also occur during the intrauterine period or the postpartum period [6].…”

Section: Introductionmentioning

confidence: 99%

Tenofovir disoproxil fumarate for preventing mother-to-child transmission of hepatitis B: a literature review

Baciu¹,

Domuncu²,

Domuncu³

et al. 2021

Clin. Exp. Obstet. Gynecol.

View full text Add to dashboard Cite

Infection with the hepatitis B virus (HBV) is one of the leading global public health issues. Over 250 million people worldwide have chronic HBV infection, out of which roughly 65 million are women in their reproductive age. The most common route of passing the infection in areas of high endemicity is by mother-to-child transmission (MTCT). In children the infection may still occur despite adequate immunoprophylaxis, however, antiviral medication, such as Tenofovir disoproxil fumarate (TDF), may be helpful in reducing the risk of MTCT. A literature review was conducted concerning TDF’s role in preventing MTCT and its safety in pregnancy. Studies were identified by researching various databases up to 2020 for variations of the following sentence: “Tenofovir disoproxil fumarate and Lamivudine and Telbivudine and Entecavir and pregnancy and transmission and safety and HBV”. Prenatal and perinatal adequate management of maternal HBV infection is of utmost importance, with focus on prevention of MTCT as the key strategy to reduce the global HBV infection burden. This review discusses the most up-to-date evidence from a multidisciplinary perspective of using TDF to reduce MTCT of HBV infection as well as its safety profile for pregnant women.

show abstract

Current evidence on the management of hepatitis B in pregnancy

Cited by 8 publications

References 86 publications

A Large Data Set; Hepatitis B and C Infection in Pregnant Females

A Large Data Set; Hepatitis B and C Infection in Pregnant Females

Knowledge, Attitude and Practices Regarding Hepatitis B among Expectant Mothers Seeking Antenatal Care in a Tertiary Care Hospital in a Metropolitan City

Tenofovir disoproxil fumarate for preventing mother-to-child transmission of hepatitis B: a literature review

Contact Info

Product

Resources

About