Current Evidence Supporting the Link Between Dietary Fatty Acids and Cardiovascular Disease

Hammad, Shatha; Pu, Shuaihua; Jones, Peter J H

doi:10.1007/s11745-015-4113-x

Cited by 160 publications

(134 citation statements)

References 72 publications

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“…From pequi pulp chemical constituents, MUFAs have been associated with improvements in lipid profile, reduced platelet aggregation, favourable modulation of blood pressure, insulin sensitivity and glycemic control (Hammad et al, 2016). Fibres are related to the regulation of intestinal function, control of body weight and lipid metabolism by decreasing the absorption and increasing excretion of cholesterol and triglycerides, and they have indirect effects on the blood pressure and serum glucose control (Lattimer and Haub, 2010).…”

Section: Introductionmentioning

confidence: 99%

Caryocar brasiliense fruit intake ameliorates hepatic fat deposition and improves intestinal structure of rats

Moreno¹,

Oliveira²,

Melo³

et al. 2016

J. Med. Plants Res.

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Caryocar brasiliense (pequi) is an exotic fruit, high in monounsaturated fat acids (MUFA) and bioactive compounds, which have beneficial effects on cardiometabolic risk factors. However, this fruit is poorly studied in this context. In this study, the effects of pequi pulp intake on cardiometabolic risk factors of rats were evaluated. Therefore, 16 male weaned rats were divided into two groups: Control group and Pequi group. Control group was feed a standard diet and pequi group, the same diet added pequi pulp (3.26 g.100 -1 ) for 15 weeks. At the end, plasma lipids, glucose, insulin, Homeostasis Model Assessment of Insulin Resistance index (HOMA-IR), blood pressure, heart rate, hepatic and fecal lipids and intestinal histomorphometric parameters were accessed. Liver and heart samples were harvested for redox status assays. There were no differences between experimental groups for blood pressure, heart rate, glucose, insulin, HOMA-IR, triglycerides, cholesterol, HDL-cholesterol, and liver and heart redox status (p<0.05). Pequi group had lowered lipid hepatic deposition and increased fecal output (p<0.05), increased intestinal villus height and crypt depth. Thus, pequi pulp intake minimized liver fat deposition by increasing its intestinal output and improved intestinal structure of rats, which can contribute for reducing cardiometabolic risk factors. MUFA, carotenoids and fibres can be associated, at last in part, with these effects.

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Section: Introductionmentioning

confidence: 99%

Caryocar brasiliense fruit intake ameliorates hepatic fat deposition and improves intestinal structure of rats

Moreno¹,

Oliveira²,

Melo³

et al. 2016

J. Med. Plants Res.

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“…Longer-chain fatty acids derived from the parental omega-3 FA alpha-linolenic acid (ALA) are partially produced endogenously, and are also considered essential: they are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), widely available in fatty fish. A great bulk of data on the association between PUFA metabolism and CV risk factors in the general population is available [53,54].…”

Section: Proteinsmentioning

confidence: 99%

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

Cosola

Sabatino

Bari

et al. 2018

Preprint

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Abstract:Chronic kidney disease (CKD) affects worldwide 8-16% of the population. In developed countries, the most important risk factors for CKD are diabetes, hypertension and obesity, calling into question the importance of educating and acting on lifestyles and nutrition. A balanced nutrition and supplementation can indeed support the maintenance of a general health status, including preservation of renal function, and help to manage and curb the main risk factors for renal damage. While the concepts of protein and salt restriction in nephrology are historically acknowledged, the role of some nutrients on renal health and the importance of nutrition as a preventative measure for renal care are less known.In this review, we provide an overview of the demonstrated and potential actions of some selected nutrients, nutraceuticals and xenobiotics on renal health and function. The effects on kidney of fibres, proteins, fatty acids, curcumin, steviol glycosides, green tea, coffee, nitrates, nitrites, and alcohol, both direct and indirect, in CKD and non-CKD condition, are reviewed here. In a view of a functional and personalized nutrition, understanding the renal and systemic effects of dietary components is essential since many chronic conditions and CKD are related to systemic dysfunctions such as chronic low-grade inflammation.

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“…increased platelet aggregation [49]. Recent studies have highlighted the importance of the LCn6/LCn3 ratio in CVD risk, rather than the amount of individual fatty acids [49].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Controversies in omega-3 efficacy and novel concepts for application

Radcliffe

Thomas

Bramley

et al. 2016

Journal of Nutrition & Intermediary Metabolism

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The interest in the cardioprotective effects of long chain omega-3 polyunsaturated fatty acids (LCn3) was largely influenced by the low rates of cardiovascular disease (CVD) amongst the Inuits of Greenland who consumed a high marine fat diet rich in LCn3s. This finding stimulated years of epidemiological and clinical studies investigating the cardioprotective effects of LCn3s, thought to be primarily mediated through anti-inflammatory (and antiaggregatory) prostaglandins that protect the vascular wall from pro-inflammatory effects of metabolic stress precipitated by poor diet and lifestyle. Although the original hypothesis of the link between LCn3s and CVD protection was based on a high LCn3 containing diet (namely a high marine fat diet) the majority of clinical trials since have focussed on EPA and DHA supplementation, and results of repeated meta-analyses have not shown conclusive evidence in support of their beneficial health effects. In this review we focus on the controversies that surround the efficacy of LCn3s in cardiovascular and other chronic diseases and present emerging areas of research for novel applications. We will examine factors that can impact on the efficacy of LCn3s such as source (plant vs marine vs supplements (algal vs marine)), stability of product, dose, trial duration, ratio of EPA:DHA, and ratio of LCn6:LCn3 fatty acids in the diet.

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Current Evidence Supporting the Link Between Dietary Fatty Acids and Cardiovascular Disease

Cited by 160 publications

References 72 publications

Caryocar brasiliense fruit intake ameliorates hepatic fat deposition and improves intestinal structure of rats

Caryocar brasiliense fruit intake ameliorates hepatic fat deposition and improves intestinal structure of rats

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

Controversies in omega-3 efficacy and novel concepts for application

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