Current indications of ex-situ liver resection: A systematic review

Serrablo, Alejandro; Gimenez-Maurel, T; Fornals, Alejandra Utrilla; Serrablo, Leyre; Azoulay, Daniel

doi:10.1016/j.surg.2022.04.002

Cited by 9 publications

(5 citation statements)

References 55 publications

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“…Overall mortality rate at 90-day was 11.6%, and mean overall survival was 55.8%, with both parameters being lower in patients undergoing ex-vivo resections for malignant tumors that those with non-malignant tumors, in alignment with previous reports (34). Importantly, in patients undergoing ex-vivo resections for malignant tumors, there was a significant relationship between the maximum tumor size and postoperative liver failure and 90-day mortality rate (33). Feasibility of the technique has been also reported in smaller series including its use for advanced CCA (35) and sarcoma-like tumors (36) with acceptable immediate liver function.…”

Section: Ex-vivo Liver Resectionssupporting

confidence: 83%

“…Therefore, its use is based on a case-by-case strict approach, and include patients with malignant and non-malignant tumors (33). A recent meta-analysis evaluated outcomes after ex-vivo resections in 29 studies with reports of 215 patients (33). As expected, R0 resections rate was 100%.…”

Section: Ex-vivo Liver Resectionsmentioning

confidence: 94%

“…Currently there are no guidelines for indications and technical considerations for these techniques. Therefore, its use is based on a case-by-case strict approach, and include patients with malignant and non-malignant tumors (33). A recent meta-analysis evaluated outcomes after ex-vivo resections in 29 studies with reports of 215 patients (33).…”

Section: Ex-vivo Liver Resectionsmentioning

confidence: 99%

“…Feasibility of the technique has been also reported in smaller series including its use for advanced CCA (35) and sarcoma-like tumors (36) with acceptable immediate liver function. However, high rate of tumor recurrence, morbidity and mortality have been reported (32)(33)(34)(35)(36).…”

Section: Ex-vivo Liver Resectionsmentioning

confidence: 99%

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Surgical approach to achieve R0 resections in primary and metastatic liver tumors: a literature review

Vargas¹,

Dar²,

Fernandes³

et al. 2023

J Gastrointest Oncol

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Background and Objective: Primary and metastatic liver tumors are a significant cause of mortality worldwide. Regardless of the etiology of the tumor, macro-and microscopically clear margins (R0) while preserving adequate function of the remaining organ are the main goals after liver resections. However, technically challenging procedures are required to achieve R0 resection. Currently, there is no consensus of which should be the ideal minimal safety margin for liver tumor resections, with contrasting reports in regards of safety, tumor recurrence and overall outcomes following R0. Therefore, we aim to review current worldwide surgical practices to achieve R0 resections for primary and metastatic liver tumors in challenging surgical techniques and their reported outcomes.Methods: PubMed database, Google Scholar, and OVID Medline were searched for peer-reviewed original articles related to surgical techniques performed to achieve R0 resections in the setting of primary and/or metastatic liver tumors. An up-to-date review of English-language articles published between 2015 to July 2022 was performed.

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Section: Ex-vivo Liver Resectionssupporting

confidence: 83%

Section: Ex-vivo Liver Resectionsmentioning

confidence: 94%

Section: Ex-vivo Liver Resectionsmentioning

confidence: 99%

Section: Ex-vivo Liver Resectionsmentioning

confidence: 99%

See 2 more Smart Citations

Surgical approach to achieve R0 resections in primary and metastatic liver tumors: a literature review

Vargas¹,

Dar²,

Fernandes³

et al. 2023

J Gastrointest Oncol

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“…This clearly affects how patients with benign liver tumours are managed. Hepatic resection is typically described in one of the following two contexts: first, as a previously reported benign liver lesion that has grown in size with or without clinical symptoms, and second, as a newly discovered liver lesion with a questionable diagnosis (14) . This is also consistent with a research done on 144 patients at the Mansoura Center, where 32 (22.2%) of the patients experienced postoperative problems.…”

Section: Discussionmentioning

confidence: 99%

Open Hepatoctomy versus Laparscopic Hepatoectomy in Patients with Benign Hepatic Lesions

Salеm,

Mohammed,

Hokkam

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: At facilities with qualified surgeons, laparoscopic methods for liver resection have gained recognition. The safety and viability of laparoscopic liver resection have improved thanks to improved methods and technological developments that have/ made it possible to regulate intrahepatic blood vessels and bile ducts better. Liver resection by minimally invasive techniques is still up for discussion. Aim: The goal of this study is to assess the immediate postoperative results of hepatic resection for benign hepatic lesions. Patients and methods: One hundred patients with a benign hepatic focal lesion participated in this cross-sectional study, 85 patients underwent open hepatoectomy and 15 patients underwent laparoscopic hepatoectomy. Results: There was no significant difference found among study groups in operative time and intraoperative complications however, bleeding was insignificantly greater among open group. Postoperative complications were higher among open group as post hepatoectomy liver failure, bile leak, chest infection, wound infection and cardiac complications but with statistically insignificant differences (p>0.05). Conclusion: This research compared the effectiveness of laparoscopic versus open liver resections, the laparoscopic group experienced fewer problems and had lower morbidity.

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Ex vivo liver resection and auto-transplantation as an alternative for the treatment of liver malignancies: Progress and challenges

Yang,

Lu,

Zhu

et al. 2024

Hepatobiliary & Pancreatic Diseases International

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Current indications of ex-situ liver resection: A systematic review

Cited by 9 publications

References 55 publications

Surgical approach to achieve R0 resections in primary and metastatic liver tumors: a literature review

Surgical approach to achieve R0 resections in primary and metastatic liver tumors: a literature review

Open Hepatoctomy versus Laparscopic Hepatoectomy in Patients with Benign Hepatic Lesions

Ex vivo liver resection and auto-transplantation as an alternative for the treatment of liver malignancies: Progress and challenges

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