Current Innovations of Metal Hexacyanoferrates-Based Nanocomposites toward Electrochemical Sensing: Materials Selection and Synthesis Methods

Lee, Pui Kee; Woi, Pei Meng

doi:10.1080/10408347.2019.1642733

Cited by 11 publications

(4 citation statements)

References 102 publications

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“…Internalization of such redox probes can be achieved by forming a charge complex during oxidation of pyrrole to PPy, which eliminates the need of an external label, simplifying the PoC application of the sensor. The PPy–HCF system has been investigated for biosensors and energy storage applications. − …”

Section: Introductionmentioning

confidence: 99%

Development of a Redox-Label-Doped Molecularly Imprinted Polymer on β-Cyclodextrin/Reduced Graphene Oxide for Electrochemical Detection of a Stress Biomarker

Goyal

Sakata

2022

ACS Omega

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Cortisol is a major stress biomarker involved in the regulation of metabolic and immune responses. Readily accessible assays with sufficient quantitative and temporal resolution can assist in prevention, early diagnosis, and management of chronic diseases. Whereas conventional assays are costly in terms of time, labor, and capital, an electrochemical approach offers the possibility of miniaturization and detection at the point-of-care. Here, we investigate the biosensor application of molecularly imprinted polypyrrole (PPy) doped with hexacyanoferrate (HCF) and coupled to reduced graphene oxide functionalized with β-cyclodextrin (β-CD). β-CD provides an inclusion site for lipophilic cortisol and was electrochemically grafted simultaneous with reduction of GO. Next, PPy was electrochemically deposited in presence of cortisol template with HCF dopant ions serving as intrinsic redox probe. Thus, the sensor response was evaluated via changes of redox peak current in cyclic voltammetry and demonstrated a broad logarithmic detection range (5 pg/mL to 5000 ng/mL, R 2 = 0.995), with a sensitivity of 8.809 μA log –1 (ng/mL) cm –2 and LOD of 19.3 pM. The sensor was shown to be specific toward cortisol in reference to salivary cortisol concentration in saliva over structural analogues. The sensor was exhibited to determine cortisol in artificial saliva at normal and elevated levels. The good performance and facile electrochemical fabrication of this antibody- and external label-free interface are promising for the development of affordable point-of-care biosensors.

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Section: Introductionmentioning

confidence: 99%

Development of a Redox-Label-Doped Molecularly Imprinted Polymer on β-Cyclodextrin/Reduced Graphene Oxide for Electrochemical Detection of a Stress Biomarker

Goyal

Sakata

2022

ACS Omega

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“…Transition metal hexacyanoferrates (MeHCF) have received considerable attention in material science and the electrochemical sensing field due to their unique characteristics–easy and cheap synthesis, good stability, ability to mediate/catalyze electrochemical reactions, and fast kinetics [ 39 , 40 ]. MeHCF deposits as electrode modifiers have been extensively investigated to exploit their electrocatalytic properties towards various organic and inorganic species.…”

Section: Electrochemical Microsensors For Ascorbic Acid Determinationmentioning

confidence: 99%

A Review on Electrochemical Microsensors for Ascorbic Acid Detection: Clinical, Pharmaceutical, and Food Safety Applications

2022

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Nowadays, micro-sized sensors have become a hot topic in electroanalysis. Because of their excellent analytical features, microelectrodes are well-accepted tools for clinical, pharmaceutical, food safety, and environmental applications. In this brief review, we highlight the state-of-art electrochemical non-enzymatic microsensors for quantitative detection of ascorbic acid (also known as vitamin C). Ascorbic acid is a naturally occurring water-soluble organic compound with antioxidant properties and its quantitative determination in biological fluids, foods, cosmetics, etc., using electrochemical microsensors is of wide interest. Various electrochemical techniques have been applied to detect ascorbic acid with extremely high sensitivity, selectivity, reproducibility, and reliability, and apply to in vivo measurements. This review paper aims to give readers a clear view of advances in areas of electrode modification, successful strategies for signal amplification, and miniaturization techniques used in the electroanalytical devices for ascorbic acid. In conclusion, current challenges related to the microelectrodes design, and future perspectives are outlined.

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“…Prussian blue (PB) nanoparticles, an iron-based nanomaterial, also serve as an inherent electrochemical activity [ 72 , 73 ]. Since Neff firstly reported the electrochemical behavior of PB and the successful deposition of a thin layer of PB on a platinum foil in 1978 [ 74 ], the wide application of PB has been promoted in various construction of electrochemical immunosensing interface, especially for its development in multiplexed electrochemical immunoassay [ 75 , 76 ].…”

Section: Electrochemical Signal Substances For Multiplexed Immunoassaymentioning

confidence: 99%

Electrochemical Signal Substance for Multiplexed Immunosensing Interface Construction: A Mini Review

Feng¹,

Chu²,

Ma³

2022

Molecules

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Appropriate labeling method of signal substance is necessary for the construction of multiplexed electrochemical immunosensing interface to enhance the specificity for the diagnosis of cancer. So far, various electrochemical substances, including organic molecules, metal ions, metal nanoparticles, Prussian blue, and other methods for an electrochemical signal generation have been successfully applied in multiplexed biosensor designing. However, few works have been reported on the summary of electrochemical signal substance applied in constructing multiplexed immunosensing interface. Herein, according to the classification of labeled electrochemical signal substance, this review has summarized the recent state-of-art development for the designing of electrochemical immunosensing interface for simultaneous detection of multiple tumor markers. After that, the conclusion and prospects for future applications of electrochemical signal substances in multiplexed immunosensors are also discussed. The current review can provide a comprehensive summary of signal substance selection for workers researched in electrochemical sensors, and further, make contributions for the designing of multiplexed electrochemical immunosensing interface with well signal.

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Current Innovations of Metal Hexacyanoferrates-Based Nanocomposites toward Electrochemical Sensing: Materials Selection and Synthesis Methods

Cited by 11 publications

References 102 publications

Development of a Redox-Label-Doped Molecularly Imprinted Polymer on β-Cyclodextrin/Reduced Graphene Oxide for Electrochemical Detection of a Stress Biomarker

Development of a Redox-Label-Doped Molecularly Imprinted Polymer on β-Cyclodextrin/Reduced Graphene Oxide for Electrochemical Detection of a Stress Biomarker

A Review on Electrochemical Microsensors for Ascorbic Acid Detection: Clinical, Pharmaceutical, and Food Safety Applications

Electrochemical Signal Substance for Multiplexed Immunosensing Interface Construction: A Mini Review

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