Current insights toward kidney injury: Decrypting the dual role and mechanism involved of herbal drugs in inducing kidney injury and its treatment

Laasya, T.P. Sri; Thakur, Shikha; Ramarao, P.; Joshi, Gaurav

doi:10.1016/j.crbiot.2020.11.002

Cited by 9 publications

(4 citation statements)

References 107 publications

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“…Other examples include the high use of naturally derived nutraceuticals that are further associated with kidney impairment. [19,20] Lack of research institute on drug discovery and biologicals:…”

Section: Social Networking and Mediamentioning

confidence: 99%

Uttarakhand COVID-19 Cases and Deaths: Comparing the Demographics and Suggestive Strategy to Prevent Similar Pandemics in Future

Joshi,

Gahtori,

Pande

et al. 2022

Preprint

Self Cite

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Coronavirus disease 19 (COVID-19) is causing a dramatic impact on human life worldwide. As of June 11 2021, later one has attributed more than 174 million confirmed cases and over 3.5 million deaths globally. Nonetheless, a World Bank Group flagship report features COVID-19 induced global crisis as the strongest post-recession since World War II. Currently, all approved therapeutics or vaccines are strictly allowed for emergency use. In the absence of pharmaceutical interventions, it is vital to analyze data set covering the growth rates of positive human cases, number of recoveries, other factors, and future strategies to manage the growth of fatal coronavirus effectively. The Uttarakhand state of India is snuggled in the lap of the Himalayas and occupies more people than Israel, Switzerland, Hong Kong, etc. In this study, we analyzed state COVID-19 data, fetched from an authenticated government repository using Python 3.9 from April 1, 2020, to February 28, 2021. In the first wave, plain areas of Uttarakhand covering the districts Dehradun, Haridwar, Nainital, and U. S. Nagar were severely affected and reported peak positive cases during the 21st – 26th week. Other hands, the hilly terrains of Uttarakhand districts, including Chamoli, Pauri Garhwal, and Rudraprayag, reported a high number of positive cases between the 30th and 31st week, and other hilly districts reported an increase in Covid-19 cases during the 34th to 38th week. The highest recovery rate was attributed to the hilly district Rudraprayag. The analysis also revealed that a very high doubling rate was seen during the last week of May to the first week of Jun 2020. At last, based on this blueprint, we have suggested 6-points solutions for preventing the next pandemic.

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Section: Social Networking and Mediamentioning

confidence: 99%

Uttarakhand COVID-19 Cases and Deaths: Comparing the Demographics and Suggestive Strategy to Prevent Similar Pandemics in Future

Joshi,

Gahtori,

Pande

et al. 2022

Preprint

Self Cite

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“…The risk is increased by the fact that access to scientifically-based knowledge about drugs or herbal substances is not universal, including healthcare professionals, and patients who self-medicate, largely relying on unverified information or scarce available data about their effects and often buying the products via the Internet. The scale of the problem is large because, according to WHO data, 60% of the world’s population and 80% of developing countries prefer herbal medicines [ 21 , 58 ].…”

Section: Risk Of Herbal Products Usementioning

confidence: 99%

Nephrotoxicity of Herbal Products in Europe—A Review of an Underestimated Problem

Kiliś‐Pstrusińska

Wiela-Hojeńska

2021

IJMS

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Currently in Europe, despite the many advances in production technology of synthetic drugs, the interest in natural herbal medicines continues to increase. One of the reasons for their popular use is the assumption that natural equals safe. However, herbal medicines contain pharmacologically active ingredients, some of which have been associated with adverse effects. Kidneys are particularly susceptible to injury induced by toxins, including poisonous constituents from medicinal plants. The most recognized herb-induced kidney injury is aristolochic acid nephropathy connected with misuse of certain Traditional Chinese herbal medicines. Data concerning nephrotoxicity of plant species of European origin are scarce. Here, we critically review significant data of the nephrotoxicity of several plants used in European phytotherapy, including Artemisia herba-alba, Glycyrrhiza glabra, Euphorbia paralias, and Aloe). Causative mechanisms and factors predisposing to intoxications from the use of herbs are discussed. The basic intention of this review is to improve pharmacovigilance of herbal medicine, especially in patients with chronic kidney diseases.

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“…The high indulgence in self-medication and the outburst of mucormycotic infection recently in the state are key examples. Other examples include the high use of naturally derived nutraceuticals that are further associated with kidney impairment 19,20 .…”

Section: Future Strategies To Mitigate Such Pandemics In Futurementioning

confidence: 99%

Uttarakhand Covid-19 Cases and Deaths: Comparing the Demographics and Suggestive Strategy to Prevent Similar Pandemics in Future

Joshi

Pande

Gupta

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Coronavirus disease 19 (Covid-19) is causing a dramatic impact on human life worldwide. As of June 11 2021, later one has attributed more than 174 million confirmed cases and over 3.5 million deaths globally. Nonetheless, a World Bank Group flagship report features Covid-19 induced global crisis as the strongest post-recession since World WarII. Currently, all approved therapeutics or vaccines are strictly allowed for emergency use. Hence, in the absence of pharmaceutical interventions, it is vital to analyze data set covering the growth rates of positive human cases, number of recoveries, other factors, and future strategies to manage the growth of fatal Covid-19 effectively. The Uttarakhand state of India is snuggled in the lap of the Himalayas and occupies more people than Israel, Switzerland, Hong Kong, etc. This study analyzed state Covid-19 data, fetched from an authenticated government repository using Python 3.9 from April 1, 2020, to February 28, 2021. The highest recovery rate was attributed to the hilly district Rudraprayag. The analysis also revealed that a very high doubling rate was seen during the last week of May to the first week of Jun 2020. At last, based on this blueprint, we have suggested 6-points solutions for preventing the next pandemic.

show abstract

Current insights toward kidney injury: Decrypting the dual role and mechanism involved of herbal drugs in inducing kidney injury and its treatment

Cited by 9 publications

References 107 publications

Uttarakhand COVID-19 Cases and Deaths: Comparing the Demographics and Suggestive Strategy to Prevent Similar Pandemics in Future

Uttarakhand COVID-19 Cases and Deaths: Comparing the Demographics and Suggestive Strategy to Prevent Similar Pandemics in Future

Nephrotoxicity of Herbal Products in Europe—A Review of an Underestimated Problem

Uttarakhand Covid-19 Cases and Deaths: Comparing the Demographics and Suggestive Strategy to Prevent Similar Pandemics in Future

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