The profession of a motor vehicle driver is potentially dangerous due to the risk of road accidents, the acquisition of professional and professionally caused diseases, sudden death at the workplace. Taking this into account, comprehensive clinical and hygienic studies were conducted, the purpose of which was to assess the occupational risk of damage to the health of drivers on the basis of data on working conditions, occupational and professionally caused diseases, road accidents and cases of sudden death at the workplace. The working conditions, the state of health of drivers were studied, the professional and professionally-conditioned morbidity and cases of sudden death at the workplace from a common disease were analyzed. It is established that the working conditions of drivers are characterized as harmful 3 classes of 1–3 degrees (class 3.1–3.3), which cause the development of occupational diseases, mainly of the musculoskeletal system; the growth of chronic professionally caused pathology (hypertension, arthropathy, dorsopathy) and the death of the driver at the workplace from a general disease. The results of the study formed the basis for the development of preventive measures.