Current Knowledge of Silver and Gold Nanoparticles in Laboratory Research—Application, Toxicity, Cellular Uptake

Talarska, Patrycja; Boruczkowski, Maciej; Żurawski, Jakub

doi:10.3390/nano11092454

Cited by 66 publications

(32 citation statements)

References 111 publications

(207 reference statements)

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“…Although these functional properties of nanoparticles are advantageous for the food industry, they are undesirable as the nanoparticles come in contact with cells in the human body. Oxidative stress is proposed as the main mechanism behind nanoparticle-induced toxicity due to the release of Ag+ after infiltrating the cells and AgNPs intracellular degradation [26,30]. The brain is particularly susceptible to ROS because of its high oxygen consumption, weak antioxidative capability, and high content of peroxidation-prone unsaturated fatty acids [31].…”

Section: Discussionmentioning

confidence: 99%

Coating-Dependent Neurotoxicity of Silver Nanoparticles—An In Vivo Study on Hippocampal Oxidative Stress and Neurosteroids

Dziendzikowska

Wilczak

Grodzicki

et al. 2022

IJMS

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Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials. The level of exposure to nanosilver is constantly raising, and a growing body of research highlights that it is harmful to the health, especially the nervous system, of humans. The potential pathways through which nanosilver affects neurons include the release of silver ions and the associated induction of oxidative stress. To better understand the mechanisms underlying the neurotoxicity of nanosilver, in this study we exposed male Wistar rats to 0.5 mg/kg body weight of AgNPs coated with bovine serum albumin (BSA), polyethylene glycol (PEG), or citrate, or to AgNO3 as a source of silver ions for 28 days and assessed the expression of antioxidant defense markers in the hippocampus of the exposed animals after 1 week of spatial memory training. We also evaluated the influence of AgNPs coating on neurosteroidogenesis in the rat hippocampus. The results showed that AgNPs disrupted the antioxidant system in the hippocampus and induced oxidative stress in a coating-dependent manner, which could potentially be responsible for neurodegeneration and cognitive disorders. The analysis of the influence of AgNPs on neurosteroids also indicated coating-dependent modulation of steroid levels with a significant decrease in the concentrations of progesterone and 17α-progesterone in AgNPs(BSA), AgNPs(PEG), and Ag+ groups. Furthermore, exposure to AgNPs or Ag+ resulted in the downregulation of selected genes involved in antioxidant defense (Cat), neurosteroid synthesis (Star, Hsd3b3, Hsd17b1, and Hsd17b10), and steroid metabolism (Ar, Er1, and Er2). In conclusion, depending on the coating material used for their stabilization, AgNPs induced oxidative stress and modulated the concentrations of steroids as well as the expression of genes involved in steroid synthesis and metabolism.

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Section: Discussionmentioning

confidence: 99%

Coating-Dependent Neurotoxicity of Silver Nanoparticles—An In Vivo Study on Hippocampal Oxidative Stress and Neurosteroids

Dziendzikowska

Wilczak

Grodzicki

et al. 2022

IJMS

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“…Green Au-NPs synthesis approach can be achieved by variable reducing, capping agents and stabilizers 10 . For example: Tamarindus indica , Benincasa hispida , Aloe vera , Rosa damascene , Cinnamomum camphora , and seed extract of pomegranate 11 – 15 have been used as reducing agents to greenly synthesize Au-NPs. Propolis (bee glue) is a resinous material collected by honeybee from the injured plant exudates and used as a constructing material of the bees’ hive.…”

Section: Introductionmentioning

confidence: 99%

In vivo bio-distribution and acute toxicity evaluation of greenly synthesized ultra-small gold nanoparticles with different biological activities

Aljohani

Hamed

Bakr

et al. 2022

Sci Rep

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Ultra-small gold nanoparticles (Au-NPs) “≤ 10 nm diameters” have potent biomedical applications. Hence, the present study aimed to greenly synthesize ultra-small gold nanoparticles using Egyptian propolis extract. Different biological activities, in vivo bio-distribution and acute toxicity study were assessed. Results revealed that, Egyptian propolis extract can successfully synthesize the highly pure and stable ultra-small Au-NPs with average diameter 7.8 nm. In vitro antimicrobial and antimycobacterial activities revealed the powerful effect of the prepared Au-NPs. Moreover, the cytotoxic effect on human cancer cell lines revealed the potent inhibition of the cancer cells’ proliferation with high reactive oxygen species-mediated apoptosis induction. In vivo bio-distribution and acute toxicity studies were performed (10 and 100 mg/kg doses) in male albino rats. The ultra-small Au-NPs showed low or no toxicity upon using the Au-NPs low dose. The mean area accumulation (%) of the Au-NPs was higher in the liver, kidney, and brain tissues (4.41, 2.96, and 0.3 times, respectively) treated with high Au-NPs dosage compared to those treated with the low dose. Surprisingly, Au-NP accumulation in brain tissue was observed in the glial cells only. Accordingly, the low dose (10 mg/kg) of Au-NPs can be used safely in a variety of biomedical applications.

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“…These properties are essential for medicines used in pharmacology and active compounds in cosmetics and nutraceuticals in fortified food. Antimicrobial properties of nanomaterials based on silver and gold nanoparticles are used both in medicine (e.g., in silver-coated patches and bandages), personal care products and cosmetics, and in the food industry (e.g., in chicken farms or in food storage equipment) [9][10][11]. There is a significant number of clinical trials involving nanoparticles; according to the ClinicalTrials.gov database, over 500 clinical trials, including nanoparticles, have been registered up to today [12].…”

Section: Of 14mentioning

confidence: 99%

Molecular Imaging and Nanotechnology—Emerging Tools in Diagnostics and Therapy

Woźniak

Płoska

Siekierzycka

et al. 2022

IJMS

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Personalized medicine is emerging as a new goal in the diagnosis and treatment of diseases. This approach aims to establish differences between patients suffering from the same disease, which allows to choose the most effective treatment. Molecular imaging (MI) enables advanced insight into molecule interactions and disease pathology, improving the process of diagnosis and therapy and, for that reason, plays a crucial role in personalized medicine. Nanoparticles are widely used in MI techniques due to their size, high surface area to volume ratio, and multifunctional properties. After conjugation to specific ligands and drugs, nanoparticles can transport therapeutic compounds directly to their area of action and therefore may be used in theranostics—the simultaneous implementation of treatment and diagnostics. This review summarizes different MI techniques, including optical imaging, ultrasound imaging, magnetic resonance imaging, nuclear imaging, and computed tomography imaging with theranostics nanoparticles. Furthermore, it explores the potential use of constructs that enables multimodal imaging and track diseases in real time.

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Current Knowledge of Silver and Gold Nanoparticles in Laboratory Research—Application, Toxicity, Cellular Uptake

Cited by 66 publications

References 111 publications

Coating-Dependent Neurotoxicity of Silver Nanoparticles—An In Vivo Study on Hippocampal Oxidative Stress and Neurosteroids

Coating-Dependent Neurotoxicity of Silver Nanoparticles—An In Vivo Study on Hippocampal Oxidative Stress and Neurosteroids

In vivo bio-distribution and acute toxicity evaluation of greenly synthesized ultra-small gold nanoparticles with different biological activities

Molecular Imaging and Nanotechnology—Emerging Tools in Diagnostics and Therapy

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