Current management of gastrointestinal stromal tumors: Surgery, current biomarkers, mutations, and therapy

Clinical Application of Circulating Tumor DNA in the Genetic Analysis of Patients with Advanced GIST

“…The incidence of GIST, the most common mesenchymal tumor of the digestive tract, has increased greatly in recent years with the development of biotechnological detection (1). Despite improvements in the prognosis of GIST patients due to the introduction of TKIs and improved surgical strategies, clinical efficiency and PFS Correlation between tumor size, Ki-67, and the concordance rate of ctDNA detection.…”

“…Gastrointestinal stromal tumors (GIST) originating from interstitial cells of Cajal (ICC) are the most common abdominal softtissue sarcomas (1). Advances in genetic diagnosis and the development of tyrosine kinase inhibitors (TKI) have yielded great improvements in the treatment of patients with GISTs.…”

Outcome of surgical resection for localized gastrointestinal stromal tumors

“…9,12 Likewise, almost one fourth of the GISTs are discovered incidentally during imaging studies due to unrelated disorder. 13 In sharp contrast with carcinomas of the digestive tract which exhibit local invasion and lymphatic and vascular dissemination, GISTs show neither local invasiveness nor lymphatic spread. Thus, similar to soft tissues sarcomas, TNM criteria (T, tumor size; N and M, lymphatic and vascular dissimination) are not practical to reflect GIST behavior.…”

“…13 Currently, multidisciplinary team including surgeon, radiologist, pathologist and medical oncologist is essential for diagnosis and precise decision regarding surgical resection, tumor characterization and adjuvant treatment. 13 GISTs were not adequately studied in the Southern part of Egypt, especially in Sohag governorate with almost 5 million populations. We carried out this study to review the clinical presentation, types of surgical intervention, histopathological characteristics an factors associated with recurrence and survival after resection of GISTs in this region.…”

Understanding the critical role for surgery in the management of wild-type gastrointestinal stromal tumor (GIST)

“…For WT GIST patients, first line therapy drug therapy with imatinib is unfortunately less effective (20). As a result, surgery is a critically important facet of treating WT GIST overall (14,21).…”