Current management of incidental gallbladder cancer: A review

Feo, Claudio F.; Ginesu, Giorgio Carlo; Fancellu, Alessandro; Perra, Teresa; Ninniri, Chiara; Deiana, Giulia; Scanu, Antonio Mario; Porcu, Alberto

doi:10.1016/j.ijsu.2022.106234

Cited by 39 publications

(26 citation statements)

References 88 publications

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“…For example, imaging diagnostics can reveal whether the infection has extended, but there are also a range of other options available for diagnosing risk. The diagnosis techniques [ 25 – 28 ] are listed below. Biopsy: this is the expulsion of a limited quantity of cells for assessment under magnification.…”

Section: Background Studymentioning

confidence: 99%

Prediction Performance of Deep Learning for Colon Cancer Survival Prediction on SEER Data

Gupta

Kalaivani

Rajasundaram

et al. 2022

BioMed Research International

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Colon and rectal cancers are the most common kinds of cancer globally. Colon cancer is more prevalent in men than in women. Early detection increases the likelihood of survival, and treatment significantly increases the likelihood of eradicating the disease. The Surveillance, Epidemiology, and End Results (SEER) programme is an excellent source of domestic cancer statistics. SEER includes nearly 30% of the United States population, covering various races and geographic locations. The data are made public via the SEER website when a SEER limited-use data agreement form is submitted and approved. We investigate data from the SEER programme, specifically colon cancer statistics, in this study. Our objective is to create reliable colon cancer survival and conditional survival prediction algorithms. In this study, we have presented an overview of cancer diagnosis methods and the treatments used to cure cancer. This paper presents an analysis of prediction performance of multiple deep learning approaches. The performance of multiple deep learning models is thoroughly examined to discover which algorithm surpasses the others, followed by an investigation of the network’s prediction accuracy. The simulation outcomes indicate that automated prediction models can predict colon cancer patient survival. Deep autoencoders displayed the best performance outcomes attaining 97% accuracy and 95% area under curve-receiver operating characteristic (AUC-ROC).

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Section: Background Studymentioning

confidence: 99%

Prediction Performance of Deep Learning for Colon Cancer Survival Prediction on SEER Data

Gupta

Kalaivani

Rajasundaram

et al. 2022

BioMed Research International

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“…In developed countries gallbladder carcinoma (GBC) is an uncommon neoplasm, whose incidence depends on geographic, age-, gender-and ethnicity-related genetics and/or environmental factors (1)(2)(3). GBC is highly aggressive, with a low 5-year survival rate, varying between 5% to 32%, and the only effective treatment depends on an early diagnosis (2,4). Half of the patients are detected incidentally during or after a cholecystectomy and fewer that 20% with non-incidental GBC are potential candidates for surgery, as it progresses silently, consequently associated with a worse prognosis (5).…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological prognostic factors for gallbladder carcinoma: a retrospective study

Ramalhosa¹,

Amaral²,

Serôdio³

et al. 2022

J Gastrointest Oncol

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Background: Gallbladder carcinoma (GBC) is an uncommon neoplasm with poor long-term survival. Worldwide the incidence rates vary according to geographic area. The multifactorial aetiology and the rarity of the disease limits the studies to improve outcomes in patients, since the treatment remains mostly surgical. The aim of this study was to identify clinicopathological prognostic factors for survival in patients with GBC submitted to surgery in our institution-a tertiary centre in Portugal. Also, to assess the expression of possible biomarkers (HER2, CD44 and ALDH1) in GBC, as well as the frequency of microsatellite instability (MSI) tumours.Methods: Clinicopathological characteristics of 41 consecutive patients that underwent surgical resection for GBC (2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)(2019) at our hospital were retrospectively reviewed. Clinicopathological factors were assessed and an immunohistochemical (IHC) analysis was done. Microsatellite stability (MSS) was considered if there was maintenance of nuclear expression of MLH1, MSH2, MSH6 and PMS2. Human epidermal growth factor receptor 2 (HER2) expression was evaluated according to the rules applied for gastric cancer and expression of CD44 and ALH1 was evaluated in order to detect cancer stem cells (CSC). Survival analysis was conducted using Kaplan-Meier and Cox regression was used to find prognostic factors.Results: Incidence of GBC in our cohort of patients was 0.45%, most commonly affecting females. Median overall survival (OS) was 23 months with a 39.6% 5-year survival rate. Stage > II [hazard ratios (HR) =8.58; P=0.007], lymphovascular invasion (LVI) (HR =4.06; P=0.045) and hepatic resection (HR =0.288; P=0.034) independently influenced survival. HER2 positivity and high expression of CD44 or ADLH1 did not show significant influence in survival (P=0.649, P=0.868 and P=0.914, respectively), although HER2 and ALDH1 positive patients showed a tendency to a shorter OS, compared to negative patients. We found no relation between these biomarkers expression and disease stage. All analysed samples had MSS.Conclusions: GBC patients with a worse prognosis can be identified. The overexpression of HER2 could select patients for targeted therapy and prompt tissue sampling in unresectable patients.

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“…Index cholecystectomy may lead to RC, and no assessment of lymph node status, reassessment of tumour staging and removal of the residual disease have a positive effect on improving patient outcomes [2,10]. Although extended resection is recommended for selected IGC patients without the disseminated disease, optimal management of IGC remains a critical issue [4,6,7,11,12]. The main reason is that residual disease detection represents a poor outcome regardless of anatomical location.…”

Section: Discussionmentioning

confidence: 99%

“…An international multicentre study in 2015 showed that patients with T2h had higher vascular invasion, neural invasion, and lymph node metastasis than patients with T2p, and T2h were often associated with worse prognosis [13]. The gallbladder adjacent to the hepatic side has no serosal layer, there are as many as 20 (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) gallbladder veins, and the tumour easily metastasises to the liver bed through the gallbladder veins [14]. RC was found in 31.4% of patients after index cholecystectomy, with the liver being the most common residual site.…”

Section: Discussionmentioning

confidence: 99%

“…Index cholecystectomy is insu cient for curative treatment of IGC staged above T1b. A study suggested that RC is associated with poor outcomes in IGC [4]. IGC is curable after R0 extended resection, but de nitive resection (including cholecystectomy, partial hepatectomy, and lymphadenectomy) is attained in only 43-63% of patients, and approximately 10-76% of these patients were found to have RC with the most common sites being the gallbladder fossa and lymph nodes [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Residual cancer is a strong predictor of survival in T3 incidental gallbladder cancer

You

Xie

Ling

et al. 2022

Preprint

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Background and PurposeIndex cholecystectomy is insufficient for curing T3 incidental gallbladder cancer (IGC), and once residual cancer (RC) is found, the prognosis is often poor. The purpose of this study was to investigate the effect of RC on the prognosis and the optimal choice of adjuvant therapy for R0 reresection patients with T3 IGC.MethodsWe retrospectively reviewed data from patients with T3 IGC who underwent radical reresection from January 2013 to December 2018. RC was defined as histologically proven cancer at reresection. Demographics and tumour treatment-related variables were analysed in correlation with RC and survival. Adjuvant (Adj) chemoradiotherapy (CRT) was correlated with overall survival (OS) and disease-free survival (DFS).ResultsOf the 167 patients with IGC who underwent surgery, 102 underwent radical extended resection. Thirty-two (31.4%) RCs were found. Hepatic side tumours (T3h) and both side tumours (T3h+T3p) were associated with the presence of RC. In multivariate analysis, RC and lymph node metastasis were independent prognostic factors for DFS and OS (P <0.05). RC was associated with a significantly shorter median OS (20 vs. 53 months; P<0.01) and DFS (11 vs. 40 months; P<0.001) despite R0 resection. For R0 reresection patients with RC and/or lymph node metastasis, Adj CRT significantly improved OS (P=0.024).ConclusionResidual cancer and lymphatic metastasis are important factors for the poor prognosis of T3 IGC despite R0 resection, and these patients should actively receive adjuvant therapy.

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Current management of incidental gallbladder cancer: A review

Cited by 39 publications

References 88 publications

Prediction Performance of Deep Learning for Colon Cancer Survival Prediction on SEER Data

Prediction Performance of Deep Learning for Colon Cancer Survival Prediction on SEER Data

Clinicopathological prognostic factors for gallbladder carcinoma: a retrospective study

Residual cancer is a strong predictor of survival in T3 incidental gallbladder cancer

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