We report a case of simultaneous microsurgical clipping of 5 cerebral aneurysms in a patient with multiple aneurysms of the anterior brain.We analyzed the existing treatment approaches to multiple cerebral aneurysms, including endovascular isolation, microsurgical clipping, as well as surgical tactics in case of subarachnoid hemorrhage. We covered the recommendations for screening, surgical risks, and approaches to aneurysm isolation (single-stage and multiple-stage).Using our own experience (since no strict guidelines are currently available), we concluded that it is important to screen cerebral vessels of all close relatives of patients with multiple and familial cerebral aneurysms.