Current Management of Wilms’ Tumor

Nakamura, Leah; Ritchey, Michael L.

doi:10.1007/s11934-009-0082-z

Cited by 46 publications

(35 citation statements)

References 59 publications

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“…Non-overgrowth syndromes include WAGR (WT, aniridia, genitourinary anomalies, mental retardation) and Denys-Drash syndromes [ 1 , 10 ]. Familial cases have an earlier age of onset and an increased incidence of bilateral disease [ 10 ].…”

Section: Defi Nitionmentioning

confidence: 99%

“…Blastemal predominant Wilms' tumors are generally more aggressive, i.e., higher stage, but usually respond to stage-specifi c therapy [ 10 ]. They contain sheets of small, round-to-ovoid cells with irregular nuclei, small nucleoli, and little cytoplasm, usually with mitotic fi gures, apoptotic bodies, and closely packed, overlapping nuclei with diffuse chromatin (Fig.…”

Section: Gross and Microscopic Featuresmentioning

confidence: 99%

“…Epithelial predominant Wilms' tumor is less aggressive but may be resistant to therapy with advanced stage [ 10 ]. It is composed of rosette-like and glomeruloid tubules lined by low columnar cells with hyperchromatic nuclei and papillary intratubular invaginations ( Fig.…”

Section: Gross and Microscopic Featuresmentioning

confidence: 99%

“…Stromal predominant Wilms' tumors, like epithelialpredominant ones, show poor clinical responses to chemotherapy [ 10 ]. They may contain hypocellular, sparse regions of immature stellate cells in a myxoid background and dense areas of primitive spindled mesenchymal cells.…”

Section: Gross and Microscopic Featuresmentioning

confidence: 99%

“…One to 3 % of patients have a family history of inherited tumors [ 1 , 9 ]. Genetically inherited cases tend to have an earlier onset and increased bilaterality [ 10 ]. Two familial genes have been specifi ed: FWT1 at 17q12-q21 and FWT2 at 19q13 [ 10 ].…”

Section: Molecular Diagnostic Features and Cytogeneticsmentioning

confidence: 99%

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Malignant Renal Tumors

Shehata

Naguib

Lin

et al. 2014

Pediatric Malignancies: Pathology and Imaging

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Renal tumors account for approximately 6-7 % of all pediatric cancers, with Wilms' tumor being the most common malignancy [ 1 , 2 ]. Current classifi cation and staging criteria for renal tumors, aided by advances in molecular and cytogenetic abnormalities, have allowed accurate diagnostic, staging, and therapeutic protocols [ 2 ], elucidated new categories of renal neoplasms, and created more inclusive classifi cation (Table 10.1 ) [ 2 , 3 ]. Overview of Imaging FeaturesThe imaging evaluation of a suspected pediatric renal mass should always begin with ultrasound. Sonography is readily available, can be performed without sedation and intravenous contrast, and does not expose the child to ionizing radiation. If a renal mass is identifi ed on ultrasound, further evaluation of the renal vessels and inferior vena cava (IVC) with both gray scale and color Doppler images are required to detect vascular extension, present in up to 10 % of cases [ 4 ]. Further evaluation with contrast enhanced computed tomography (CT) or magnetic resonance imaging (MRI) is also required for local staging of the mass prior to any intervention, as per the guidelines of the Children's Oncology Group (COG). Either modality can be used, depending on institutional availability and expertise [ 5 ].In keeping with the As Low As Reasonably Achievable (ALARA) principle regarding ionizing radiation exposure, pre-contrast and multiphase contrast enhanced CT images are not required for diagnosis or staging of pediatric renal tumors [ 6 ]. A single-phase study in the portal venous phase (approximately 50 s after contrast injection) suffi ciently stages a renal tumor and delineates relevant anatomy. Multiplanar CT reconstructions or multiplanar scanning with MRI can confi rm the renal origin of the mass and assess its relationship to vital structures such as the renal vessels. If a partial nephrectomy is being considered, multiphase images are helpful to determine the relationship of the mass to the renal vessels and collecting system. A CT of the chest is required in all malignant renal tumors to evaluate for potential lung metastasis. Wilm's Tumor Defi nitionWilms' tumor ( syn: nephroblastoma), a malignant neoplasm originating from nephrogenic blastemal cells, is the second most common malignant, solid extracranial tumor in children [ 1 , 7 , 8 ]. It is a traditional blastematous tumor, exhibiting various stages of embryonic development and multiple lines of differentiation. Clinical Features and EpidemiologyIn children ranging from 0 to 15 years of age, Wilms' tumor occurs in seven to ten cases per million annually (1 in 10,000 children) and accounts for approximately 95 % of renal tumors, and comprises 6-7 % of all pediatric tumors [ 7 , 9 , 10 ]. It is the fi fth most common pediatric tumor and the second most common intraabdominal tumor in children [ 11 ].

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Section: Defi Nitionmentioning

confidence: 99%

Section: Gross and Microscopic Featuresmentioning

confidence: 99%

Section: Gross and Microscopic Featuresmentioning

confidence: 99%

Section: Gross and Microscopic Featuresmentioning

confidence: 99%

Section: Molecular Diagnostic Features and Cytogeneticsmentioning

confidence: 99%

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Malignant Renal Tumors

Shehata

Naguib

Lin

et al. 2014

Pediatric Malignancies: Pathology and Imaging

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Comparison of 3-Dimensional and Augmented Reality Kidney Models With Conventional Imaging Data in the Preoperative Assessment of Children With Wilms Tumors

et al. 2019

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Key Points Question What is the value of 3-dimensional (3-D) visualization methods, augmented reality holograms, and 3-D printing for the preoperative assessment of anatomical structures in children with Wilms tumors? Findings In this survey study of 7 pediatric surgeons for which 10 personalized, augmented reality holograms and 3-D prints of children with Wilms tumors were created, there was a significant added value from the 3-D visualization methods compared with conventional imaging for the preoperative assessment. Meaning Three-dimensional visualizations may provide added value for the pediatric surgeon in the anatomical assessment of Wilms tumors, may help in future preoperative planning of nephron-sparing surgery, and may be considered an innovative supplementary visualization in clinical care.

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Wilms Tumor

2012

Handbook of Pediatric Hematology and Oncology

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Current Management of Wilms’ Tumor

Cited by 46 publications

References 59 publications

Malignant Renal Tumors

Malignant Renal Tumors

Comparison of 3-Dimensional and Augmented Reality Kidney Models With Conventional Imaging Data in the Preoperative Assessment of Children With Wilms Tumors

Wilms Tumor

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