“…Impaired nephron development leads to a nephron deficit later in life, which is associated with adult cardiorenal disease. Cardiorenal (or reno‐cardiac) syndromes, one form of distant organ dysfunction in renal disease, are associated with divergent pathologies such as cardiac fibrosis . The umbrella terminology of cardiorenal syndromes also subsumes bidirectional interactive pathophysiologies between the kidney and the cardiovascular system, which significantly affect morbidity and cost of care …”