Current medical management of endocrine-related male infertility

Ring, Joshua; Lwin, Aye Aye; Köhler, Tobias

doi:10.4103/1008-682x.179252

Cited by 76 publications

(61 citation statements)

References 70 publications

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“…Infertility is a complex and multifactorial health problem having extensive socio-economic implications. The current global trend of significant deterioration in male reproductive potential is indeed a matter of great concern (Ring, Lwin, & Köhler, 2016). Concomitant with the rise in infertility worldwide, obesity in reproductive age men has nearly tripled during the past decades (Palmer, Bakos, Owens, Setchell, & Lane, 2012).…”

Section: Discussionmentioning

confidence: 99%

Testicular germ cell apoptosis and sperm defects in mice upon long‐term high fat diet feeding

Ghosh

Mukherjee

2018

Journal Cellular Physiology

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The growing prevalence of male infertility is a matter of serious concern. One of the putative causes being nutritional excess from continuous consumption of high fat diet (HFD) leading to insulin resistance albeit the specific relationship is not fully understood. Besides, there are many contradictions in the available literature on the subject. Therefore, we sought to characterize in detail the effects of HFD upon testicular function and sperm quality in mice with particular focus on isolated testicular germ cells and spermatozoa, respectively. In this study, we treated 8-week old male Swiss albino mice with HFD for the duration of 5 months; control animals were reared on standard diet. We observed HFD induced progressive deterioration of testicular histoarchitecture leading to disruption of seminiferous tubules, increased vacuolization, and partial to complete tubular atrophy. Time dependent adverse effects on sperm count, motility, and morphology were noticed. Interestingly, numerous anomalies were detectable in sperm head and tail structures reflecting loss of reproductive capacity due to HFD. Maximal tissue and sperm damage was conspicuous at the endpoint, prompting us to examine oxidative stress markers. Enhanced intracellular reactive oxygen species (ROS) generation, augmentation of prooxidant activities, and compromised testicular antioxidant defences clearly implied conditions of oxidative stress in long-term HFD treated mice. This was concomitant with the onset of abnormally enhanced testicular germ cell apoptosis involving the mitochondrial intrinsic pathway. Thus, our findings revealed that ROS mediated deregulation of testicular germ cell apoptosis is critical in male reproductive impairment due to diet induced obesity.

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Section: Discussionmentioning

confidence: 99%

Testicular germ cell apoptosis and sperm defects in mice upon long‐term high fat diet feeding

Ghosh

Mukherjee

2018

Journal Cellular Physiology

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“…Ten to fifteen per cent of couples fail to conceive after 1 year of unprotected intercourse. Male factor infertility is the sole culprit in 20% of infertile couples and a contributing factor in another 40% (Chehab, Madala, & Trussell, ; Cocuzza & Agarwal, ; Ring, Lwin, & Kohler, ). Male infertility and hypogonadism often co‐exist.…”

Section: Introductionmentioning

confidence: 99%

Improvements in semen parameters in men treated with clomiphene citrate—A retrospective analysis

et al. 2019

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Clomiphene citrate (CC) is commonly used off‐label for the treatment of male infertility, yet there is limited data to guide patient selection. To identify a subset of patients more likely to benefit from CC, we aimed to define predictors of improvement in semen parameters among men receiving CC. We retrospectively analysed 151 men treated with at least 25 mg CC daily for male infertility and/or hypogonadism at two institutions between 2004 and 2014. Men previously on testosterone were excluded. The primary outcome was change in semen parameters. Variables included baseline patient characteristics, pre‐treatment hormone profiles and pre‐treatment semen analyses. A total of 77 men met inclusion criteria. Median length of therapy was 2.8 months. There was significant improvement in sperm concentration (14–21 million/ml; p = 0.002) and total motile count (TMC; 13–28 million; p = 0.04). One third of patients who began with fewer than 5 million motile spermatozoon improved to a TMC > 5 million, increasing reproductive options to include intrauterine insemination. Patient characteristics, pre‐treatment hormone profile and degree of oligozoospermia did not predict treatment response. While no predictors of improvement were identified, clinically useful response rates are described for use in shared decision‐making.

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“…Low testicular T levels can impair spermatogenesis. However, elevated E 2 levels inhibit pituitary gonadotropin secretion, resulting in down-regulation of Leydig cell function, decreased T production and decreased T levels in both the testis and serum [36]. The balance between serum androgen and estrogen levels is essential for maintaining normal spermatogenesis by means of the serum levels of SHBG, which transports androgens and estrogens in blood and regulates steroid access to target tissues.…”

Section: Discussionmentioning

confidence: 99%

Effects of Qilin pills on spermatogenesis, reproductive hormones, oxidative stress, and the TSSK2 gene in a rat model of oligoasthenospermia

Zhang

et al. 2020

BMC Complement Med Ther

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AbstractsBackground: Qilin pills (QLPs), a classic Traditional Chinese Medicine (TCM) formula for treating male infertility, effectively improve semen quality in clinical trials. This study was designed to evaluate the effects of QLPs on spermatogenesis, reproductive hormones, oxidative stress, and the testis-specific serinekinase-2 (TSSK2) gene in a rat model of oligoasthenospermia. Methods: Forty adult male Sprague-Dawley (SD) rats were randomly divided into four groups. The rat model with oligoasthenospermia was generated by intragastric administration of tripterygium glycosides (TGs) once daily for 4 weeks. Then, two treatment groups were given different doses (1.62 g/kg and 3.24 g/kg) of QLPs once daily for 60 days. Sperm parameters, testicular histology and reproductive hormone measurements, oxidative stress tests, and TSSK2 expression tests were carried out.Results: QLPs effectively improved semen parameters and testicular histology; restored the levels of FSH, LH, PRL, fT, and SHBG; reduced the levels of oxidative stress products (ROS and MDA); increased testicular SOD activity; and restored the expression of spermatogenesis-related gene TSSK2. Conclusion:QLPs have a therapeutic effect on a rat model of oligoasthenospermia, and this effect is manifested as improvement of semen quality and testis histology, gonadal axis stability, decreased oxidative stress, and the regulation of testis-specific spermatogenesis-related gene TSSK2.

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Current medical management of endocrine-related male infertility

Cited by 76 publications

References 70 publications

Testicular germ cell apoptosis and sperm defects in mice upon long‐term high fat diet feeding

Testicular germ cell apoptosis and sperm defects in mice upon long‐term high fat diet feeding

Improvements in semen parameters in men treated with clomiphene citrate—A retrospective analysis

Effects of Qilin pills on spermatogenesis, reproductive hormones, oxidative stress, and the TSSK2 gene in a rat model of oligoasthenospermia

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