Current Medications for the Treatment of Alzheimer’s Disease

Finn, Laura A.

doi:10.1016/b978-0-12-802810-0.00004-0

Cited by 11 publications

(3 citation statements)

References 24 publications

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“…At present, approved pharmacological treatment for AD includes cholinesterase inhibitors (ChEIs) and N-methyl-d-aspartate (NMDA) glutamate receptor antagonists. Moreover, in 2014, FDA also approved a combination of memantine and ChEIs for patients with moderate-to-severe AD [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective Effect of Quercetin and Memantine against AlCl3-Induced Neurotoxicity in Albino Wistar Rats

Jadhav

Kulkarni

2023

Molecules

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Recent evidences indicate that there is a substantial increase in worldwide cases of dementia. Alzheimer's disease is the leading cause of dementia and may contribute to 60–70% of cases. Quercetin is a unique bioflavonoid that has numerous therapeutic benefits such as anti-allergy, anti-ulcer, anti-inflammatory, anti-hypertensive, anti-cancer, immuno-modulatory, anti-infective, antioxidant, acetylcholinesterase inhibitory activity, neuroprotective effects, etc. In the present study, we evaluated the neuroprotective effect of orally administered quercetin with memantine in albino Wistar rats after inducing neurotoxicity through AlCl3 (100 mg/kg, p.o.). Chronic administration of AlCl3 resulted in poor retention of memory and significant oxidative damage. Various behavioral parameters, such as locomotor activity, Morris water maze, elevated plus maze, and passive avoidance test, were assessed on days 21 and 42 of the study. The animals were euthanatized following the completion of the last behavioral assessment. Various oxidative stress parameters were assessed to know the extent of oxidative damage to brain tissue. Quercetin with memantine has shown significant improvement in behavioral studies, inhibition of AChE activity, and reduction in oxidative stress parameters. Histopathological studies assessed for cortex and hippocampus using hematoxylin and eosin (H&E), and Congo red stain demonstrated a reduction in amyloid-β plaque formation after treatment of quercetin with memantine. Immunohistochemistry showed that quercetin with memantine treatment also improved the expression of brain-derived neurotrophic factor (BDNF) and inhibited amyloid-β plaque formation. The present study results demonstrated protective effects of treatment of quercetin with memantine in the neurotoxicity linked to aluminum chloride in albino Wistar rats .

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Section: Introductionmentioning

confidence: 99%

“…Further other systemic effects related to cholinergic activity include urinary urgency, bradycardia, and syncope. Because of this, close monitoring of the patient and dose titration has been recommended [ 8 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Quercetin and Memantine against AlCl3-Induced Neurotoxicity in Albino Wistar Rats

Jadhav

Kulkarni

2023

Molecules

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“…Currently, the drugs used for the symptomatic treatment of AD act by limiting the hydrolysis of synaptic acetylcholine [ 9 , 10 ]. This approach has proven to be effective in improving the intellectual functions of patients suffering from AD [ 11 , 12 ]. However, the used drugs cause various adverse effects including hepatotoxicity, vomiting, fatigue, muscle cramps [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Combined computational approaches for developing new anti-Alzheimer drug candidates: 3D-QSAR, molecular docking and molecular dynamics studies of liquiritigenin derivatives

Nour¹,

Daoui²,

Abchir³

et al. 2022

Heliyon

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Functionalized Graphene Quantum Dots as an Eco‐Friendly Fluorescent Probe for Galantamine Analysis: Greenness Evaluation With Application to Pharmacokinetics Monitoring

Alosaimi,

Almalki,

Abduljabbar

et al. 2024

Luminescence

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In this study, the use of functionalized graphene quantum dots (GQDs) as a fluorescent probe has been investigated for the quantitative determination of galantamine, a choline esterase inhibitor used for the treatment of Alzheimer's disease. The GQDs exhibit a significant quenching in their fluorescence intensity upon interaction with galantamine allowing for sensitive and selective detection of the drug. This quenching process follows a dynamic pattern with a linear relationship between fluorescence intensity and the concentration of galantamine. Several factors affecting the quenching process were investigated and optimized, including the concentration of GQDs, the pH of the solution, and the incubation time. The proposed probe exhibited excellent analytical performance with a linear range of 10–500 ng/mL, a limit of detection of 15 ng/mL, accuracy of 100.78 ± 0.698%, and intraday and interday precision of 0.742 and 1.369%, respectively. Furthermore, the GQDs‐based sensor exhibited good selectivity towards galantamine in the presence of potentially interfering substances. Another advantage of the GQDs‐based sensor is its greenness evaluation, as it offers a more environmentally friendly alternative compared to traditional methods. In addition, the GQDs‐based sensor was successfully applied to analyze galantamine in pharmaceutical samples and in vivo samples, demonstrating its potential for pharmacokinetics monitoring.

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Current Medications for the Treatment of Alzheimer’s Disease

Cited by 11 publications

References 24 publications

Neuroprotective Effect of Quercetin and Memantine against AlCl3-Induced Neurotoxicity in Albino Wistar Rats

Neuroprotective Effect of Quercetin and Memantine against AlCl3-Induced Neurotoxicity in Albino Wistar Rats

Combined computational approaches for developing new anti-Alzheimer drug candidates: 3D-QSAR, molecular docking and molecular dynamics studies of liquiritigenin derivatives

Functionalized Graphene Quantum Dots as an Eco‐Friendly Fluorescent Probe for Galantamine Analysis: Greenness Evaluation With Application to Pharmacokinetics Monitoring

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