Current NCI-sponsored Cooperative Group trials of endocrine therapies in breast cancer

Eng‐Wong, Jennifer; Zujewski, Jo Anne

doi:10.1002/cncr.23188

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…Similar to that experience, the CCOP network facilitated the completion of studies in the development of OncoType DX, a genotype scoring system that evaluates patients' risk of cancer recurrence. Specimens and data from previous trials were used to develop and validate OncoType DX,48 and an ongoing NCI trial (Program for the Assessment of Clinical Cancer Tests or PACCT‐1)49 will evaluate the need for chemotherapy in hormone‐responsive patients who have OncoType DX scores that are difficult to interpret. For physicians and patients who are considering treatment, the findings from that study will better inform their balancing of the risk of recurrence with other considerations and whether the prospective chemotherapy treatment benefits will justify the risks 50.…”

Section: Overview: the National Cancer Institute Community Clinical Omentioning

confidence: 99%

Translating research into evidence‐based practice

Minasian

Carpenter

Weiner

et al. 2010

Cancer

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The recent rapid acceleration of basic science is reshaping both our clinical research system and our healthcare delivery system. The pace and growing volume of medical discoveries are yielding exciting new opportunities, yet we continue to face old challenges to maintain research progress and effectively translate research into practice. The National Institutes of Health and individual government programs increasingly are emphasizing research agendas that involve evidence development, comparative-effectiveness research among heterogeneous populations, translational research, and accelerating the translation of research into evidence-based practice as well as building successful research networks to support these efforts. For more than 25 years, the National Cancer Institute Community Clinical Oncology Program has successfully extended research into the community and facilitated the translation of research into evidence-based practice. By describing its keys to success, this article provides practical guidance to cancer-focused, provider-based research networks as well as those in other disciplines. Cancer 2010;116:4440-9. V C 2010 American Cancer Society.KEYWORDS: translational research, evidence-based medicine, research and technology, organization and delivery of care, quality of care.Clinical research and medicine have entered a time of great promise, but they also are faced with new challenges. The rapid acceleration of basic science, including advances in genomics and proteomics, are elucidating mechanisms of disease, yielding new methods to identify and potentially treat abnormalities, and effectively are transforming acute diseases into chronic diseases. These advances signify substantial progress in our national research endeavor; however, they simultaneously are reshaping not only the entire clinical research system but also our healthcare delivery system and the practice of clinical medicine. The pace and volume of medical discoveries and evolving clinical practice and corresponding policy require the development of new evidence in comparative effectiveness and outcomes, which recently have experienced tremendous increases in investment through the American Recovery and Reinvestment Act of 2009 and other substantial efforts. 1,2 Thus, as we proceed through this transformation and face new research and clinical practice demands, the question of how best to improve the translation of clinical research into clinical practice remains unanswered, and the substantial discovery-delivery gap remains.The National Institutes of Health (NIH) established the NIH Roadmap Initiative (the Roadmap) to address these challenges and other needs in the scientific community. 3 Through the Roadmap, as 1 means of restructuring its clinical research enterprise, the NIH is exploring practice-based research networks (PBRNs) to pursue the twin goals of accelerating science and facilitating the translation of research into practice. [4][5][6]

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Section: Overview: the National Cancer Institute Community Clinical Omentioning

confidence: 99%

Translating research into evidence‐based practice

Minasian

Carpenter

Weiner

et al. 2010

Cancer

View full text Add to dashboard Cite

show abstract

“…Unfortunately, very few genomic biomarkers have made the transition from the laboratory to the clinic, but those that have either cleared the hurdle of clinical validation or are being considered in large-scale clinical trials to establish their clinical validity are promising (Slodkowska and Ross 2009;Straver et al 2010;Ross et al 2008;Cardoso et al 2007;Mook et al 2007;Mamounas et al 2008;Marchionni et al 2007;Eng-Wong and Zujewski 2008;Habel et al 2006). Unfortunately, very few genomic biomarkers have made the transition from the laboratory to the clinic, but those that have either cleared the hurdle of clinical validation or are being considered in large-scale clinical trials to establish their clinical validity are promising (Slodkowska and Ross 2009;Straver et al 2010;Ross et al 2008;Cardoso et al 2007;Mook et al 2007;Mamounas et al 2008;Marchionni et al 2007;Eng-Wong and Zujewski 2008;Habel et al 2006).…”

Section: Clinical Validitymentioning

confidence: 99%