Current outcome of antenatally diagnosed exomphalos: an 11 year review

Lakasing, Lorin; Cicero, S.; Davenport, Mark; Patel, Shailesh; Nicolaides, Kypros H.

doi:10.1016/j.jpedsurg.2006.04.015

Cited by 72 publications

(86 citation statements)

References 19 publications

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“…Two reports have, however, studied the gender-specific effect of M235T polymorphism and DN, and found an association between the T allele and risk of DN in men only [38, 39]. Those studies proposed that TT genotype by itself was not sufficient to increase the susceptibility to DN and that the high blood pressure (defined as SBP 160 or DBP 95 mm Hg) of the men in their studies may have contributed to the deterioration in renal function [38, 39]. In our study, the mean level of SBP and DBP was less than 130/80 mm Hg in both sexes.…”

Section: Discussionmentioning

confidence: 99%

Gender-Dependent Effect of ACE I/D and AGT M235T Polymorphisms on the Progression of Urinary Albumin Excretion in Taiwanese with Type 2 Diabetes

Tien

Hsiao²,

Hsu³

et al. 2008

Am J Nephrol

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Background: We investigated the gender differences in the effect of ACE I/D and AGT M235T polymorphisms on the prognosis of diabetic nephropathy (DN). Methods: A total of 525 type 2 diabetics were enrolled to participate in this prospective observational study. ACE and AGT gene polymorphisms were analyzed by polymerase chain reaction. The progression of DN was defined as a shift to a higher stage of DN or a doubling of the baseline serum creatinine level by the end of the study. Results: The baseline biophysical parameters show no gender differences in progression and non-progression of DN. The women who were ACE D allele carriers were found to be at an increased risk of DN progression compared to those with II genotypes (p = 0.024, OR 2.176). No such difference was seen in male patients (p = 0.619, OR 0.833). After adjusting for confounding factors (age, SBP, DBP, BMI, HbA1c, total cholesterol, TG, HDL-C, LDL-C, ACEI, and ARB) in our multiple regression analysis, these women were still found to be at increased risk of progressing to more severe DN (p = 0.008, OR 3.082) but not the men (p = 0.183, OR 0.586). Neither the AGT TT genotype nor the T allele were associated with the progression of DN in either sex after adjusting for confounding factors. Conclusion: Our follow-up study suggests that female diabetic carriers of the ACE D allele might be at an increased risk of DN progression.

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Section: Discussionmentioning

confidence: 99%

Gender-Dependent Effect of ACE I/D and AGT M235T Polymorphisms on the Progression of Urinary Albumin Excretion in Taiwanese with Type 2 Diabetes

Tien

Hsiao²,

Hsu³

et al. 2008

Am J Nephrol

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“…An abnormal karyotype, additional malformations and genetic syndromes can be found in up to 80% of the cases [4,5]. As a matter of fact, a large study describing the outcome of cases diagnosed antenatally showed that less than 10% reach operative repair [4].…”

Section: Introductionmentioning

confidence: 99%

“…As a matter of fact, a large study describing the outcome of cases diagnosed antenatally showed that less than 10% reach operative repair [4]. Likewise, other series have reported poor perinatal outcome, due to associated anomalies, and highlight the importance of careful antenatal assessment and appropriate counseling for the parents [6,7].…”

Section: Introductionmentioning

confidence: 99%

Should We Measure Fetal Omphalocele Diameter for Prediction of Perinatal Outcome?

Kiyohara

Brizot²,

Liao³

et al. 2013

Fetal Diagn Ther

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Objective: To evaluate the fetal omphalocele diameter/abdominal circumference ratio (OD/AC) as a predictor of adverse perinatal outcome. Methods: Analysis involving 47 singleton pregnancies with fetal omphalocele, normal karyotype and absence of other major abnormalities. The OD/AC ratio was determined antenatally by ultrasound and the best cutoff for the prediction of neonatal death was determined by receiver operating characteristic curve analysis. Additional secondary outcomes included need for oral intubation in the first 24 h of life, two-step surgery or use of synthetic mesh, reoperation, parenteral feeding and need for respiratory assistance >21 days, time to first oral feed, and time to hospital discharge. Results: Fetal OD/AC did not change significantly with gestational age. Postnatal death occurred in 10 (21.3%) cases and the best cutoff for prediction was an OD/AC ratio ≥0.26. In pregnancies with the first ultrasound evaluation performed before 31 weeks' gestation and an OD/AC ≥0.26, the likelihood ratio for needing intubation in the first 24 h of life was 2.6 (95% CI: 1.2-5.7), needing two-step surgery or use of mesh was 4.9 (95% CI: 1.9-14.4), and postnatal death was 4 (95% CI: 1.9-7.5). Conclusion: A fetal ultrasound OD/AC ratio ≥0.26 is associated with increased postnatal morbidity and mortality.

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“…Fetal Diagn Ther 2019;45:332-338 DOI: 10.1159/000489260 [7] and small omphaloceles may disappear later in pregnancy [8]. Kagan et al [9] even described spontaneous resolution at 20 weeks in 92.5% of first-trimester-diagnosed omphaloceles in euploid fetuses.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of First-Trimester Physiological Midgut Herniation Using Three-Dimensional Ultrasound

Bogers¹,

Baken²,

Cohen–Overbeek³

et al. 2018

Fetal Diagn Ther

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Introduction:The aim of this study was to investigate the development of midgut herniation in vivo using three-dimensional (3D) ultrasonographic volume and distance measurements and to create reference data for physiological midgut herniation in ongoing pregnancies in a tertiary hospital population. Materials and Methods: The transvaginal 3D ultrasound volumes of 112 women, seen weekly during the first trimester of pregnancy, were obtained and subsequently analysed in a virtual reality environment. The width of the umbilical cord insertion, the maximum diameter of the umbilical cord, and the volume of midgut herniation were measured from 6 until 13 weeks gestational age (GA). Results: All parameters had a positive relation with GA, crownrump length, and abdominal circumference. In approximately 1 of 10 volumes no midgut herniation could be observed at 9 and 10 weeks GA. In 5.0% of the fetuses the presence of midgut herniation could still be visualised at 12 weeks GA. Conclusion: Reference charts for several dimensions of physiological midgut herniation were created. In the future, our data might be used as a reference in the first trimester for comparison in case of a suspected pathological omphalocele.

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Current outcome of antenatally diagnosed exomphalos: an 11 year review

Cited by 72 publications

References 19 publications

Gender-Dependent Effect of ACE I/D and AGT M235T Polymorphisms on the Progression of Urinary Albumin Excretion in Taiwanese with Type 2 Diabetes

Gender-Dependent Effect of ACE I/D and AGT M235T Polymorphisms on the Progression of Urinary Albumin Excretion in Taiwanese with Type 2 Diabetes

Should We Measure Fetal Omphalocele Diameter for Prediction of Perinatal Outcome?

Evaluation of First-Trimester Physiological Midgut Herniation Using Three-Dimensional Ultrasound

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