Current perspective of diethylstilbestrol (DES) exposure in mothers and offspring

Jishi, T. Al; Sergi, Consolato

doi:10.1016/j.reprotox.2017.04.009

Cited by 69 publications

(32 citation statements)

References 111 publications

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“…Studies have shown that the presence of DES has affected multiple signaling pathways in the body, but this is not yet fully clarified. It is now commonly believed that early DES exposure causes its effects by genetic and epigenetic alterations, not by changes in gene mutation [92]. Neonatal exposure to DES can cause extensive changes in gene expression that persist into adulthood.…”

Section: Diethylstilbestrolmentioning

confidence: 99%

Oestrogenic Endocrine Disruptors in the Placenta and the Fetus

Tang

Deng

et al. 2020

IJMS

130

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Endocrine disrupting chemicals (EDCs) are exogenous substances that interfere with the stability and regulation of the endocrine system of the body or its offspring. These substances are generally stable in chemical properties, not easy to be biodegraded, and can be enriched in organisms. In the past half century, EDCs have gradually entered the food chain, and these substances have been frequently found in maternal blood. Perinatal maternal hormone levels are unstable and vulnerable to EDCs. Some EDCs can affect embryonic development through the blood-fetal barrier and cause damage to the neuroendocrine system, liver function, and genital development. Some also effect cross-generational inheritance through epigenetic mechanisms. This article mainly elaborates the mechanism and detection methods of estrogenic endocrine disruptors, such as bisphenol A (BPA), organochlorine pesticides (OCPs), diethylstilbestrol (DES) and phthalates (PAEs), and their effects on placenta and fetal health in order to raise concerns about the proper use of products containing EDCs during pregnancy and provide a reference for human health.

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Section: Diethylstilbestrolmentioning

confidence: 99%

Oestrogenic Endocrine Disruptors in the Placenta and the Fetus

Tang

Deng

et al. 2020

IJMS

130

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“…It was given to pregnant women to prevent miscarriage, its pharmaceutical use discontinued in the United States only in 1971 after the discovery of a cancer cluster in young women exposed in utero. DES changes the epigenome of exposed organisms, particularly during early development, and resulting alterations in gene expression cause multigenerational reproductive abnormalities and cancer risks in descendents of women who took DES (Al Jishi and Sergi 2017).…”

Section: Enter Growth Promotersmentioning

confidence: 99%

A metabolic history of manufacturing waste: food commodities and their outsides

Landecker

2019

Food, Culture & Society

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The early twentieth-century industrialization of food production and processing generated large volumes of processing waste. Following the fate of waste products cast off from the new food commodities, this article describes the logics and practices of large-scale waste reuse as animal feed and microbial nutrient medium in industrial chemical production in the United States.A "chemical gaze" on matter recast disparate burdensome byproducts such as beet pulp, cottonseed meal, or arsenic trioxide in terms of resources to be fed forward through microbial and animal metabolism. Focused on feed efficiency and growth promotion, this chemical gaze was selectively attuned to growth yet blind to the emerging infrastructure of waste-as-feed as a massive circulatory system for both nutrients and the toxicants introduced by growth promoters. Following metabolic pathways of materials over time, this history is at once an account of animal feed systems in twentieth-century America, and a tracing of the externalities of food commodities as they pass through different chemical forms.

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“…These ideas are helpful in assessing cause and effect but cannot prove an association. For example, there may be a small exposure with a large effect occurring only rarely, such as pregnant women exposed to diethylstilbestrol (DES), an estrogen drug used to prevent abortions, and their daughters who were observed to have an increased chance of a rare vaginal carcinoma (transitional cell cancer); moreover, some offspring of the daughters of women exposed to DES also had some abnormalities . This is difficult to explain with a temporal association, and even biologic plausibility, of DES exposure in utero causing cancer decades later, which is very remote from the exposure.…”

mentioning

confidence: 99%

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Pope

2019

Arthritis & Rheumatology

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Current perspective of diethylstilbestrol (DES) exposure in mothers and offspring

Cited by 69 publications

References 111 publications

Oestrogenic Endocrine Disruptors in the Placenta and the Fetus

Oestrogenic Endocrine Disruptors in the Placenta and the Fetus

A metabolic history of manufacturing waste: food commodities and their outsides

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