Current Perspective of Zika Virus and Vaccine Development

Manna, Sourav; Dey, Sumanta; Biswas, Subhamoy; Nandy, Ashesh; Basak, Subhash C.

doi:10.14218/erhm.2020.00060

Cited by 1 publication

(1 citation statement)

References 81 publications

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“…The ‘smart’ vaccine strategy uses advanced machine learning to peptide-based epitope mapping and it precisely predicts the binding between viral peptides and human proteins, leading to an increase in the speed of the design and development of broad spectrum (‘universal’) vaccines ( Du et al, 2022 ). This computational approach, thanks to continuous progress in bioinformatics, structural biology (including the huge growth in high-resolution 3D structures of proteins) and genomics, has economic and time-effective value, shortening many experimental steps, and will leading to new advanced paradigms for vaccines design for any upcoming deadly pathogen ( Manna et al, 2021 ; Soltan et al, 2021 ).…”

Section: Landscape Of Opportunities: Topical Insightsmentioning

confidence: 99%

Smart therapies against global pandemics: A potential of short peptides

et al. 2022

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BackgroundAs we entered the third year of this pandemic, since the World Health Organisation (WHO) declared in March 2020 the novel coronavirus severe acute respiratory syndrome (SARS-CoV2) outbreak as a global pandemic COVID-19 (COronaVIrus Disease 19), we are still fighting with newer and newer viral mutations. The pandemic has passed the grim milestone of over 6.4 million COVID19 deaths, from more than 550 million reported cases thus far. In fact, more than 15 million people can die by the end of this year. It is highly likely that this pandemic will become endemic, while the full evolutionary potential of coronaviruses has yet to be revealed. The next pandemic is coming. A microbe with features of SARS-Middle East respiratory syndrome (MERS) and SARS-CoV-2 could lead to significantly more catastrophic loss of life. The co-evolution with other viruses should not be neglected. According to the WHO, we should expect diverse zoonotic, outbreakprone microbes, including highly pathogenic strains of influenza, Nipah, Ebola, Zika, or hemorrhagic fever viruses. 'It's an evolutionary certainty that there will be another virus with the potential to be more transmittable and deadly than this one', said Tedros Adhanom Ghebreyesus, director-general of the WHO. On the other hand, in both poor countries and regions of armed conflict, where vaccination is hampered, historic diseases are re-emerging, with migration and displacement influencing transmission risk and limiting control, and raising potential for additional outbreaks. Furthermore, there are other looming terrible threats to humanity as damaging as the bubonic plagues, such as bioterrorism or antibiotic resistant microorganisms. In most cases, both effective prevention and treatment options are limited.

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Section: Landscape Of Opportunities: Topical Insightsmentioning

confidence: 99%