Current perspective on circadian function of the kidney

Abstract

Behavior and function of living systems are synchronized by the 24-hour rotation of the earth that guides physiology according to time of day. However, when behavior becomes misaligned from the light/dark cycle, such as in rotating shift work, jet lag, and even unusual eating patterns, adverse health consequences such as cardiovascular or cardiometabolic disease can arise. The discovery of cell autonomous molecular clocks expanded interest in regulatory systems that control circadian physiology including within the kidney where function varies along a 24-hour cycle. Our understanding of the mechanisms for circadian control of physiology is in the early stages and so the current review provides an overview of what is known and the many gaps in our current understanding. We include a particular focus on the impact of eating behaviors, especially meal timing. A better understanding of the mechanisms guiding circadian function of the kidney are expected to reveal new insights into causes and consequences of a wide range of disorders involving the kidney including hypertension, obesity, and chronic kidney disease.

It’s All About the CREY!

“… 5 The kidneys also have a profound circadian rhythm. 6 Studies have shown that renal injury and cardiovascular dysfunction are present when any of the core regulating genes for circadian rhythm are knocked out. 7 Also, a study on mice showed that coronary ischemia reperfusion injury was more severe during the sleep-to-wake transition than during the wake-to-sleep transition.…”