Parasites pose a potential threat to livestock farming by inflicting heavy economic losses, thus, emphasizing their control for successful farming. Conventionally, this control has long been achieved through anti-parasitic drugs. However, due to the emergence of resistance in parasites against these drugs and the presence of their residues in animal products, there is an increased interest in searching for safe and effective alternatives like garlic. Garlic is a natural spice that is enriched with many health-beneficial compounds. Historically, it has long been used as a natural remedy for certain diseases. Recent research on garlic, especially its organosulfur compounds, has shown a wide range of therapeutic effects. It bears antioxidant, antiparasitic, antihypertensive, and antimicrobial properties. It is effective against various protozoa and helminths of ruminants. It modulates the gastrointestinal environment and works as a growth-promoting agent in ruminants. However, there exist some barriers to the practical application of garlic in ruminants which are also discussed in this chapter.