Current perspectives of oleic acid: Regulation of molecular pathways in mitochondrial and endothelial functioning against insulin resistance and diabetes

Rehman, Kanwal; Haider, Kamran; Jabeen, Komal; Akash, Muhammad Sajid Hamid

doi:10.1007/s11154-020-09549-6

Cited by 64 publications

(54 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Palmitic acids also reduced the insulin-stimulated IRS-1 tyrosine phosphorylation in the myotubes from lean subjects [21], and increased insulin resistance in C2C12 skeletal muscle cells [40]. In contrast, oleic acid has been described to protect from IR [41]. In rodent muscle, oleic acid promoted GLUT4 through the PI3K pathway, preventing the effects of palmitic acid [42].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oleic Acid Protects Against Insulin Resistance by Regulating the Genes Related to the PI3K Signaling Pathway

Lopez‐Gómez

Santiago‐Fernández

García‐Serrano

et al. 2020

JCM

View full text Add to dashboard Cite

Background: The effects of different types of fatty acids on the gene expression of key players in the IRS1/PI3K signaling pathway have been poorly studied. Material and Methods: We analyzed IRS1, p85α, and p110β mRNA expression and the fatty acid composition of phospholipids in visceral adipose tissue from patients with morbid obesity and from non-obese patients. Moreover, we analyzed the expression of those genes in visceral adipocytes incubated with oleic, linoleic, palmitic and dosahexaenoic acids. Results: We found a reduced IRS1 expression in patients with morbid obesity, independent of insulin resistance, and a reduced p110β expression in those with lower insulin resistance. A positive correlation was found between p85α and stearic acid, and between IRS1 and p110β with palmitic and dosahexaenoic acid. In contrast, a negative correlation was found between p85α and oleic acid, and between IRS1 and p110β with linoleic, arachidonic and adrenic acid. Incubation with palmitic acid decreased IRS1 expression. p85α was down-regulated after incubation with oleic and dosahexaenoic acid and up-regulated with palmitic acid. p110β expression was increased and decreased after incubation with oleic and palmitic acid, respectively. The ratio p85α/p110β was decreased by oleic and dosahexaenoic acid and increased by palmitic acid. Conclusions: Our in vitro results suggest a detrimental role of palmitic acid on the expression of gene related to insulin signaling pathway, with oleic acid being the one with the higher and more beneficial effects. DHA had a slight beneficial effect. Fatty acid-induced regulation of genes related to the IRS1/PI3K pathway may be a novel mechanism by which fatty acids regulate insulin sensitivity in visceral adipocytes.

show abstract

Section: Discussionmentioning

confidence: 99%

“…In rodent muscle, oleic acid promoted GLUT4 through the PI3K pathway, preventing the effects of palmitic acid [42]. There are different mechanisms by which oleic acid prevents IR, such as reducing ER and mitochondrial stress, increasing mitochondrial β-oxidation and preventing inflammation [26,41,43,44].…”

Section: Discussionmentioning

confidence: 99%

Oleic Acid Protects Against Insulin Resistance by Regulating the Genes Related to the PI3K Signaling Pathway

Lopez‐Gómez

Santiago‐Fernández

García‐Serrano

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…Furthermore, it can be used as a pharmaceutical base agent or adjuvant agent with high stability and safety (Zhang, Huang, Pu, & Guan, 2007). Therefore, oleic acid is not only a highly safe anticancer agent, but can also be added to the nutritional preparations of cancer patients as an active ingredient to improve the nutritional status of patients (Rehman, Haider, Jabeen, & Akash, 2020).…”

Section: Application Of Different Lipids In Cancer Malnutritionmentioning

confidence: 99%

New perspective toward nutritional support for malnourished cancer patients: Role of lipids

Wang

Zhang

Liu

et al. 2021

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

To improve the difficulties related to malnutrition, nutritional support has become an essential part of multidisciplinary comprehensive treatment for cancer. Lipids are essential nutrient source for the human body, and nowadays in clinical practices, it has a positive interventional effect on patients suffering from cancer. However, contribution of lipids in nutritional support of cancer patients is still poorly understood. Moreover, the sensory and physicochemical properties of lipids can severely restrict their applications in lipid‐rich formula foods. In this review article, for the first time, we have presented a summary of the existing studies which were related to the associations between different lipids and improved malnutrition in cancer patients and discussed possible mechanisms. Subsequently, we discussed the challenges and effective solutions during processing of lipids into formula foods. Further, by considering existing problems in current lipid nutritional support, we proposed a novel method for the treatment of malnutrition, including developing individualized lipid nutrition for different patients depending on the individual's genotype and enterotype. Nonetheless, this review study provides a new direction for future research on nutritional support and the development of lipid‐rich formula foods for cancer patients, and probably will help to improve the efficacy of lipids in the treatment of cancer malnutrition.

show abstract

“…These patients constitute almost 80% of diabetes population and the impact of atherosclerosis in this group is more apparent, thus, showing an increased mortality rate in this group (Colwell et al., 1981; DeFronzo & Ferrannini, 1991). Studies have shown that endothelial dysfunction in T2DM is often associated with insulin resistance which may then result into atherosclerosis (Pinkney et al., 1997; Rehman, Haider, Haider, Jabeen, & Akash, 2020).…”

Section: Atherosclerosis and Types Of Diabetes Mellitusmentioning

confidence: 99%

Pathophysiology of atherosclerosis: Association of risk factors and treatment strategies using plant‐based bioactive compounds

et al. 2020

Self Cite

View full text Add to dashboard Cite

Under physiological conditions, endothelial cells act as protective barrier which prevents direct contact of blood with circulating factors via production of tissue plasminogen activator. Risk factors of metabolic disorders are responsible to induce endothelial dysfunction and may consequently lead to prognosis of atherosclerosis. This article summarizes the process of atherosclerosis which involves number of sequences including formation and interaction of AGE-RAGE, activation of polyol pathway, protein kinase C, and hexosamine-mediated pathway. All these mechanisms can lead to the development of oxidative stress which may further aggravate condition. Different pharmacological interventions are being used to treat atherosclerosis, however, these might be associated with mild to severe side effects. Therefore, plantbased bioactive compounds having potential to combat and prevent atherosclerosis in diabetic patients are attaining recent focus. By understanding process of development and mechanisms involved in atherosclerotic plaque formation, these bioactive compounds can be better option for future therapeutic interventions for atherosclerosis treatment.

show abstract

Current perspectives of oleic acid: Regulation of molecular pathways in mitochondrial and endothelial functioning against insulin resistance and diabetes

Cited by 64 publications

References 103 publications

Oleic Acid Protects Against Insulin Resistance by Regulating the Genes Related to the PI3K Signaling Pathway

Oleic Acid Protects Against Insulin Resistance by Regulating the Genes Related to the PI3K Signaling Pathway

New perspective toward nutritional support for malnourished cancer patients: Role of lipids

Pathophysiology of atherosclerosis: Association of risk factors and treatment strategies using plant‐based bioactive compounds

Contact Info

Product

Resources

About