Current Pharmacological Management of Aortic Aneurysm

Xiang, Bitao; Zhu, Shichao; Li, Jun; Lai, Hao; Wang, Chunsheng; Zhu, Kai

doi:10.1097/fjc.0000000000001054

Cited by 5 publications

(2 citation statements)

References 148 publications

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“…Endothelial dysfunction is accompanied by the inability of aortic wall smooth muscle cells to generate force through the elastin-contractile units in response to pulsatile blood flow [ 7 , 47 ]. Current pharmacotherapy includes a wide range of medications, including antihypertensive and antidiabetic [ 48 , 49 ]. The potential of anti-inflammatory agents and antibiotic therapy requires large, randomized studies to be regarded as a therapeutic option, as the effective pharmacotherapy of aortic dilatation is still lacking [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Demographical and Clinical Factors Predictive for Aortic Dilatation. When should we be Concerned about the Size?

Urbanowicz,

Rajewska-Tabor,

Olasińska-Wiśniewska

et al. 2024

Rev. Cardiovasc. Med.

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Background: Thoracic aortic aneurysms are often an accidental finding and result from a degenerative process. Medical therapy includes pharmacological control of arterial hypertension and smoking cessation, that slows the growth of aneurysms. An association between the dilatation of the ascending and abdominal aorta has been already reported. The aim of the study was to identify possible demographic and clinical factors that may implicate further imaging diagnostics in patients with ascending aorta dilatation. Methods: There were 181 (93 (53%) males and 88 (47%) females) patients with a median age of 54 (41–62) years who underwent cardiac magnetic resonance due to non-vascular diseases, were enrolled into retrospective analysis. Results: Multivariable analysis revealed ascending aorta dilatation (odds ratios (OR) = 7.45, 95% confidence interval (CI): 1.98–28.0, p = 0.003) and co-existence of coronary artery disease (OR = 8.68, 95% CI: 2.15–35.1, p = 0.002) as significant predictors for thoracic descending aorta dilatation. In patients with abdominal aorta dilatation, the multivariable analysis showed a predictive value of ascending aortic dilatation (OR = 14.8, 95% CI: 2.36–92.8, p = 0.004) and age (OR = 1.04, 95% CI: 1.00–1.08, p = 0.027). In addition, cut-off values were established for age groups determining the risk of thoracic aorta dilatation over 49 years and abdominal aorta dilatation over 54 years. Conclusions: The results of our analysis showed predictive factors, including ascending aorta dilatation and co-existence of coronary artery disease, particularly over 49 years of age for thoracic, while ascending aorta dilatation and age, particularly over 54 years, for abdominal aorta dilatation. These features may be considered to increase clinical vigilance in patients with aortic diameter abnormalities.

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Section: Discussionmentioning

confidence: 99%

Demographical and Clinical Factors Predictive for Aortic Dilatation. When should we be Concerned about the Size?

Urbanowicz,

Rajewska-Tabor,

Olasińska-Wiśniewska

et al. 2024

Rev. Cardiovasc. Med.

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“…Alternative intervention strategies, such as the use of β-adrenergic blocking agents, have been proposed to slow down abnormal aneurysm progression, although recent evidence has raised doubts about their effectiveness (7)(8). Understanding the mechanisms underlying the progression from AA to AD could provide valuable insights for the development of novel treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

Identification of the ceRNA axis of circ_0000006/miR-483-5p/KDM2B in the progression of aortic aneurysm to aorta dissection

Liu,

Tan,

Wang

et al. 2024

Preprint

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Background Aortic aneurysm (AA) and aortic dissection (AD) are serious cardiovascular disorders with a high risk of mortality. The molecular mechanisms underlying the progression from AA to AD are not well understood. This study aimed to identify the key circular RNA (circRNA)-microRNA (miRNA)-messenger RNA (mRNA) regulatory axis involved in this disease progression. Methods CircRNA microarray, miRNA microarray, and mRNA sequencing were performed on plasma samples from healthy controls, AA patients, and AD patients. Bioinformatics analysis integrated the expression profiles to identify dysregulated circRNA-miRNA-mRNA networks. Key molecules were validated in vascular smooth muscle cells (VSMCs) and an AD mouse model. Cell proliferation, migration, and phenotypic transition assays were conducted after modulating the identified circRNA. The impact on AD progression was evaluated in mice upon circRNA knockdown. Results A total of 12 circRNAs were found upregulated in AD compared to AA samples. miR-483-5p was downregulated while its targets KDM2B and circ_0000006 were upregulated in AD. Silencing circ_0000006 in VSMCs inhibited PDGF-induced phenotypic switching, proliferation, and migration by increasing miR-483-5p and decreasing KDM2B levels. In the AD mouse model, knockdown of circ_0000006 alleviated disease progression with similar molecular changes. Conclusion The study identified a novel circ_0000006/miR-483-5p/KDM2B axis dysregulated during AD progression. Targeting this axis, especially circ_0000006, could be a potential strategy to mitigate the transition from AA to AD by modulating VSMC phenotype and function.

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Sarcopenia defined by the psoas muscle mass or quality is associated with poor survival in patients with aortic aneurysm undergoing surgery: A meta-analysis

Dong

Wang

et al. 2023

Ageing Research Reviews

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Current Pharmacological Management of Aortic Aneurysm

Cited by 5 publications

References 148 publications

Demographical and Clinical Factors Predictive for Aortic Dilatation. When should we be Concerned about the Size?

Demographical and Clinical Factors Predictive for Aortic Dilatation. When should we be Concerned about the Size?

Identification of the ceRNA axis of circ_0000006/miR-483-5p/KDM2B in the progression of aortic aneurysm to aorta dissection

Sarcopenia defined by the psoas muscle mass or quality is associated with poor survival in patients with aortic aneurysm undergoing surgery: A meta-analysis

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