Current Possibilities and Potential Development of Molecular Enterovirus Surveillance. Experience of Russian Federation

Lukashev, Alexander N.; Golitsina, L. N.; Vakulenko, Yulia A.; Akhmadishina, Ludmila V.; Romanenkova, N. I.; Sapega, E. Yu.; Morozova, Nadezhda S.; Новикова, Н. А.; Троценко, О. Е.; Ivanova, Olga E.

doi:10.15789/2220-7619-2018-4-452-464

Cited by 5 publications

(1 citation statement)

References 36 publications

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“…вирус CVA6 также стал выделяться чаще остальных энтеровирусов [15]. Подобная смена основных возбудителей энтеровирусных экзантемных заболеваний c доминированием вируса СVА6 в последнее десятилетие наблюдалась и в других странах, включая РФ [1,3,4,29].…”

Section: этиологические агенты энтеровирусной инфекции во вьетнамеunclassified

Enterovirus infection in the Socialist Republic of Vietnam

Голицына

Нгуен

Romanenkova

et al. 2019

Russian Journal of Infection and Immunity

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Human enterovirus infections comprise a group of infectious diseases caused by viruses of Enterovirus A-D species (genus Enterovirus, family Picornaviridae). Enterovirus infections can vary in clinical manifestations and severity, from asymptomatic infection to serious multisystem diseases. During evolution, enterovirus strains with increased neurovirulence or atypical pathogenicity may emerge exhibiting an epidemic potential. Recently, outbreaks of enterovirus infection with an increased rate of neurological manifestations, a significant percentage of severe cases and lethal outcomes have been observed worldwide, which were associated with enteroviruses EV-A71, EV-D68 etc. The World Health Organization has included EV-A71 and EV-D68 enterovirus infection together with some other dangerous viral diseases considered for inclusion in the List of Blueprint Priority Diseases. In connection with this, global enterovirus surveillance is important for controlling emergence and spread of epidemic enterovirus variants, prediction of establishing epidemic situation, timely conduction of preventive measures and vaccine development. A growing multi-field cooperation between Russia and Vietnam leads to increased two-way population migration, which actualizes scientific and practical collaboration in surveillance and control of infectious disease spread, including enterovirus infection. Currently, epidemiological surveillance of enterovirus infection in Vietnam is based on monitoring hand, foot and mouth disease (HFMD) rate, laboratory diagnostics of enterovirus infection and identification of enterovirus strains, mainly detected in severe patients. In 2001–2016, 34 non-polio virus types were identified in patients with enterovirus infection, largely represented by viruses EV-A71, CVA6, CVA10, and CVA16. Moreover, the peak incidence of enterovirus infection and related mortality rate were associated with the increased activity of EV-A71 virus. In Vietnam, EVA71 enterovirus of genotypes C1, C4, C5 and B5 circulated at different times. Over the last years, a new pandemic genotype virus CVA6 has been dominating as a causative agent of enterovirus infection in Vietnam as well as the majority of other countries. The data on phylogenetic relation between Vietnamese epidemic EV-A71 and CVA6 strains allowed to find that they underwent multiple betweencountry spreads, whereas their subsequent in-country dissemination resulted in 2011–2012 enterovirus outbreak and sustained high-level HFMD morbidity.

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Section: этиологические агенты энтеровирусной инфекции во вьетнамеunclassified

Enterovirus infection in the Socialist Republic of Vietnam

Голицына

Нгуен

Romanenkova

et al. 2019

Russian Journal of Infection and Immunity

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Blood Anti-Surface Proteins Echovirus 30 (Enterovirus, Picornaviridae) Antibodies in Residents of the Nizhny Novgorod Region

Melentev,

Novikov,

Lapin

et al. 2024

Russian Journal of Infection and Immunity

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Echovirus 30 (Е30) is an enterovirus that causes severe forms of serous meningitis. Over many years, E30 virus has caused serous meningitis outbreaks all over the world including Russia, but the status of anti-E30 population immunity remains unexplored. In 2022, the average percentage of all pediatric admission enterovirus cases in Russia was 97%; the most severe E30 infection cases were registered in children under 17 years of age. The virus capsid surface contains proteins VP1, VP2 and VP3 with homologous epitopes common to other enterovirus proteins, which allows them to be used as an antigen for antibody detection. The work was aimed at assessing frequency of different antibody classes specific to full-length recombinant E30 VP1, VP2 and VP3 proteins. 331 blood serum samples collected from 2 months-to 61 year-old residents of the Nizhny Novgorod region were used in the study. E30 VP1, VP2 and VP3 proteins were expressed in Escherichia coli, purified chromatographically and used antigenically for detection of IgA, IgG and IgM antibodies by using enzyme-linked immunosorbent immunoassay. Most study subjects had antibodies specific to only one or two of the E30 surface proteins. IgA, IgG and IgM antibodies to three recombinant proteins were detected simultaneously in 0.3%, 4.2% and 2.7% of cases. Totally, anti-E30 protein IgG antibodies were detected in 29.9% of cases. The maximum detection rate of antibodies (50.0%) was recorded in pediatric groups that decreased with age. IgG antibodies were found in 9.3% of the tested individuals. The detection rate (16.6%) peaked in the age group of children from 7 to 11 years. The IgM antibody-obtained data evidence that during the study period, almost one in every ten-study participant was infected with enteroviruses. The results of analyzing long-term immunity specific to enteroviral proteins showed the highest frequency of detected IgG antibodies in children that tended to decline with age as well as about continued E30 virus circulation in the Nizhny Novgorod region.

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Molecular epidemiological and clinical aspects of enterovirus infection in the south of Russia

Ковалев

Твердохлебова

Simovanyan

2023

Med. vestn. Ûga Ross.

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Objective: the study of molecular epidemiological and clinical aspects of EVI in the Rostov region for the period 2006-2020. to improve the disease surveillance system. Research methods: epidemiological, virological, molecular biological (PCR, sequencing, phylogenetic analysis), microbiological, statistical. Materials and methods: the analysis of medical records of 139 patients with EVI was carried out. Samples of biomaterial (feces, throat swab) from 17293 people, samples from environmental objects (2710 samples), strains of enteroviruses (EV) in the amount of 142 specimens were studied. Results: in the Rostov region until 2013. sporadic incidence of EVI prevailed with registration from 1 to 38 cases per year. June 2013 there was a sharp increase in the incidence of EVI with the formation of local foci in organized groups, associated with the circulation of a new genotype — EV 71 type of subgenotype C4 of “Chinese” origin (622 patients with EVI were registered, one death). The clinical features of the disease were determined: acute onset with manifestations of intoxication, foot and mouth disease-like syndromes, followed by the development of CNS pathology in 37.4% of patients. According to the results of sequencing of biomaterial samples from patients and virus carriers for the period 2006-2020. EVs of 22 types were detected. Conclusions: EVs are subject to intense genetic variability, due to which new genovariants pathogenic for humans may appear. The change in EV genotypes, which dominated the circulation among the population of the Rostov region, determined the rise in the incidence of EVI in 2013. A significant diversity of non-polio EV genotypes was revealed, while the structure of EV genovariants changed in different years.

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Current Possibilities and Potential Development of Molecular Enterovirus Surveillance. Experience of Russian Federation

Cited by 5 publications

References 36 publications

Enterovirus infection in the Socialist Republic of Vietnam

Enterovirus infection in the Socialist Republic of Vietnam

Blood Anti-Surface Proteins Echovirus 30 (Enterovirus, Picornaviridae) Antibodies in Residents of the Nizhny Novgorod Region

Molecular epidemiological and clinical aspects of enterovirus infection in the south of Russia

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