Current potential health benefits of sulforaphane

Kim, Jae Kwang; Park, Sang Un

doi:10.17179/excli2016-485

Cited by 17 publications

(2 citation statements)

References 54 publications

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“…Thus, it is expected that the administration of an SFN-rich broccoli sprout preparation will result in increased bioavailability compared to the administration of a naturally less enriched broccoli leaf flour. SFN is one of the most studied metabolites with promising pharmacological effects [17,[61][62][63]; therefore, a high bioavailability of SFN in the body is desirable. SFN is an indirect antioxidant due to its ability to induce the expression of several antioxidant enzymes via the KEAP1/Nrf2/ARE pathway, which maintain redox potential and activity of free radical scavengers such as vitamins A, C and E [64].…”

Section: Glucoraphanin (Gr) Sulforaphane (Sfn) and Sfn Conjugatesmentioning

confidence: 99%

Absorption and Excretion of Glucosinolates and Isothiocyanates after Ingestion of Broccoli (Brassica oleracea L. var italica) Leaf Flour in Mice: A Preliminary Study

Martins,

Ferreira,

Colaço

et al. 2023

Nutraceuticals

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During the harvesting of the broccoli plant, the leaves are discarded, being considered a by-product that may be up to 47% of total broccoli biomass, representing a large amount of wasted material. The use of broccoli leaves is of great interest in the sense that this wasted material is rich in health promoter compounds, such as isothiocyanates. In this study, C57BL/6J mice ingested 790 mg/kg broccoli leaf flour, and the presence of glucosinolates and isothiocyanates in the plasma, liver, kidney, adipose tissue, faeces and urine was analysed at 1, 2, 4, 8, 12 and 24 h post-ingestion. In plasma, only glucoerucin (GE), glucobrassicin (GB), sulforaphane (SFN) and indol-3-carbinol (I3C) were detected, and all four compounds peaked between 4 and 8 h after ingestion. The compounds SFN, SFN-glutathione (SFN-GSH), SFN–cysteine (SFN-CYS) and SFN-N-acetyl-cysteine (SFN-NAC) were excreted in faeces at high levels, while glucoraphanin (GR), the precursor of SFN, was not detected in any biological samples other than urine. In the liver, the compounds GE, SFN-CYS, SFN-NAC and I3C were detected, while in the kidney, only GE, GB and SFN-GSH were present. None of the glucosinolates and isothiocyanates analysed were detected in fat tissue. These results demonstrate that glucosinolates and their derivatives were absorbed into the bloodstream and were bioavailable after ingestion of powdered broccoli leaves.

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Section: Glucoraphanin (Gr) Sulforaphane (Sfn) and Sfn Conjugatesmentioning

confidence: 99%

Absorption and Excretion of Glucosinolates and Isothiocyanates after Ingestion of Broccoli (Brassica oleracea L. var italica) Leaf Flour in Mice: A Preliminary Study

Martins,

Ferreira,

Colaço

et al. 2023

Nutraceuticals

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“…Sulforaphane (1-isothiocyanato-4-(methylsulfinyl)butane, SFN), a potent antioxidant, is mainly extracted from cruciferous vegetables including cabbage, broccoli, and cauliflower. As a dietary phytocompound belonging to the isothiocyanate family, SFN is converted from glucoraphanin, a precursor enriched in cruciferous vegetables. − SFN has aroused the interest of numerous researchers due to multiple beneficial properties, including anti-cancer, anti-inflammatory, antioxidant, and cytoprotective effects by directly regulating redox metabolism, − mitochondrial quality control, immune response, febrile illness and heat shock stress, and synaptic plasticity or indirectly cellular antioxidant defense through Nrf2-mediated glutathione. ,,− Han et al reported that SFN is a potential candidate for prevention/treatment of Parkinson’s disease . SFN was also reported to preserve mitochondrial function by eliminating mitochondrial oxidant stress …”

Section: Introductionmentioning

confidence: 99%

Sulforaphane Acts Through NFE2L2 to Prevent Hypoxia-Induced Apoptosis in Porcine Granulosa Cells via Activating Antioxidant Defenses and Mitophagy

Zhang

Chen

et al. 2022

J. Agric. Food Chem.

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In mammals, a vast majority of ovarian follicles undergo atresia, which is caused by granulosa cell (GC) apoptosis. GCs in follicles are exposed to low oxygen. Hypoxia triggers reactive oxygen species (ROS) generation, which leads to cell oxidative stress and apoptosis. Sulforaphane (SFN), a phytochemical isothiocyanate enriched in cruciferous vegetables, has exhibited a crucial role in mitigating oxidative stress. To explore the effect of SFN on porcine GC apoptosis in a hypoxic environment, we handled the established hypoxia model (1% O2) of cultured porcine GCs with SFN. Results showed that SFN rescued hypoxia-induced apoptosis and viability of GCs. Meanwhile, SFN increased the expression of antioxidant enzymes and reduced the accumulation of ROS in GC cytoplasm and mitochondria under hypoxia. Mechanically, SFN activated the transcription factor of redox-sensitive nuclear factor-erythroid 2-related factor 2 (NFE2L2) entering the nucleus, further inducing mitophagy and increased antioxidant capacity, finally alleviating the adverse effect of hypoxia on porcine GCs. In conclusion, SFN inhibited hypoxia-evoked GC apoptosis by activating antioxidant defenses and mitophagy through NFE2L2. New targets may be provided for regulating follicular development and atresia by these findings.

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A clinical study and future prospects for bioactive compounds and semi-synthetic molecules in the therapies for Huntington's disease

Islam,

Jony,

Thufa

et al. 2023

Mol Neurobiol

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Current potential health benefits of sulforaphane

Cited by 17 publications

References 54 publications

Absorption and Excretion of Glucosinolates and Isothiocyanates after Ingestion of Broccoli (Brassica oleracea L. var italica) Leaf Flour in Mice: A Preliminary Study

Absorption and Excretion of Glucosinolates and Isothiocyanates after Ingestion of Broccoli (Brassica oleracea L. var italica) Leaf Flour in Mice: A Preliminary Study

Sulforaphane Acts Through NFE2L2 to Prevent Hypoxia-Induced Apoptosis in Porcine Granulosa Cells via Activating Antioxidant Defenses and Mitophagy

A clinical study and future prospects for bioactive compounds and semi-synthetic molecules in the therapies for Huntington's disease

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