Current practice of diagnosis and reporting of prostate cancer on needle biopsy among genitourinary pathologists

Egevad, Lars; Allsbrook, William C.; Epstein, Jonathan I.

doi:10.1016/j.humpath.2005.10.011

Cited by 47 publications

(28 citation statements)

References 25 publications

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“…13 Interobserver variability in diagnosing HGPIN likely accounts for the variability in incidence rate, [14][15][16] as well as technical factors in the processing of core biopsy specimens, which affect histologic quality. 17 The incidence of HGPIN increases with patient age and is highest among African American men and lower among Asian men, paralleling the disparate incidences of cancer in these ethnic groups.…”

Section: Epidemiology and Clinical Implications Of Hgpinmentioning

confidence: 99%

Precursor Lesions of Urologic Malignancies

Khani¹,

Robinson²

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Precursor lesions of urologic malignancies are established histopathologic entities, which are important not only to recognize for clinical purposes, but also to further investigate at the molecular level in order to gain a better understanding of the pathogenesis of these malignancies. Objective.— To provide a brief overview of precursor lesions to the most common malignancies that develop within the genitourinary tract with a focus on their clinical implications, histologic features, and molecular characteristics. Data Sources.— Literature review from PubMed, urologic pathology textbooks, and the 4th edition of the World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs. All photomicrographs were taken from cases seen at Weill Cornell Medicine or from the authors' personal slide collections. Conclusions.— The clinical importance and histologic criteria are well established for the known precursor lesions of the most common malignancies throughout the genitourinary tract, but further investigation is warranted at the molecular level to better understand the pathogenesis of these lesions. Such investigation may lead to better risk stratification of patients and potentially novel treatments.

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Section: Epidemiology and Clinical Implications Of Hgpinmentioning

confidence: 99%

Precursor Lesions of Urologic Malignancies

Khani¹,

Robinson²

2017

Archives of Pathology &Amp; Laboratory Medicine

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“…In the past, unequivocal diagnosis of extraprostatic extension of prostatic carcinoma has been based on the presence of prostate glands in adipose tissue and prostate glands in perineural spaces of neurovascular bundles in needle biopsy specimens [1]. Therefore, the presence of glands in the fat has been interpreted as an evidence of extraprostatic spread by the prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The detection of prostatic adenocarcinoma invading adipose tissue is an extremely important finding and one with significant clinical implication [1]. In the literature, there are rare isolated reports of prostatic adipose tissue [2,3].…”

Section: Introductionmentioning

confidence: 99%

Intraprostatic adipose tissue: a study of 427 whole mount radical prostatectomy specimens

Kee

Jennings

et al. 2009

Human Pathology

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“…In the event of multiple, discontinuous tumor foci within a single core, the summed foci lengths, excluding intervening benign prostatic tissue, were used to define the percentage of cancer involvement. 15 The biopsy cores were generally 1 cm long, such that the lengths of core involvement in millimeters and the percentage of involvement were comparable. The GPC was defined as the greatest percentage of cancer involvement in a single core, irrespective of the core GS.…”

Section: Patient Characteristics and Treatmentmentioning

confidence: 99%