Current Practice of Primary Flexor Tendon Repair

Development of antisense oligonucleotide (ASO) technology against Tgf‐β signaling to prevent scarring during flexor tendon repair

“…Fibrous adhesions between the tendon and synovial sheath disrupt the near frictionless gliding of the FT that is required for digit range of motion, and can impair the function of the entire hand. Although improvements in surgical techniques and new physical therapy protocols have dramatically improved FT repair outcomes [2, 3], there remains an unmet need to augment the healing process. More recently, biological approaches have emerged as potential approach to enhance FT healing and reduce adhesion formation, including delivery or inhibition of growth factors [4–6], with Transforming Growth Factor β (Tgf-β) signaling being one such candidate [5, 7].…”

Surface Modification with Chemically Modified Synovial Fluid for Flexor Tendon Reconstruction in a Canine Model in Vivo

“…Direct repair immediately after flexor injury is standard clinical practice [4][5][6] , but flexor tendon reconstruction may be needed to restore tendon function if the primary repair has failed 7,8 . Flexor tendon Disclosure: One or more of the authors received payments or services, either directly or indirectly (i.e., via his or her institution), from a third party in support of an aspect of this work.…”

Enlargement of the flexor pulleys by an omega plasty: A study comparing the release of one or both sides of the A2 and/or A4 pulley

“…Several biomechanical studies have shown that the pulley rupture threshold was 407 N/m to A2 and 324 N/m to A4 [5]. Some authors consider that partial section of A2 and A4 pulleys does not alter their mechanical function nor increase their risk of rupture [6][7][8][9][10][11][12][13][14]. Several clinical studies have reported adhesions after pulley plasties [4,14,15].…”