Infective endocarditis (IE), despite its low incidence, is a serious disease, with hospital mortality of 15-20%, reaching up to 40% per year. 1 For almost 70 years, several international guidelines have recommended antibiotic use to prevent IE in patients considered at risk, before procedures capable of generating bacteremia. [2][3][4][5] At the beginning of the 20th century, oral cavity was recognized as an important and frequent entry point for bacteremia. 1,2,6 Subsequently, antibiotic usage was shown to reduce the incidence of bacteremia after dental extraction, which supported the recommendation for the use of antibiotic prophylaxis before risky oral/dental procedures to prevent IE in patients with risky cardiac conditions. 6 Recently, however, many specialty societies began to question the effectiveness of this approach, due to