“…According to the pioneering work of Thomas et al, the G protein-coupled estrogen receptor GPER, a class A (rhodopsin-like) GPCR, interacts with estradiol ( Thomas et al, 2005 ). This membrane protein is involved in a panel of pathophysiological actions including cardiovascular and digestive diseases ( DeLeon et al, 2020 ; Groban et al, 2020 ), immune response ( Notas et al, 2021 ), metabolic disorders ( Sharma et al, 2018 ), neuroprotection ( Pemberton et al, 2022 ) and cancer such as triple negative breast cancer ( Zhang et al, 2024 ). Therefore, GPER has generated increasing attention in the scientific community and the synthesis of GPER modulators could open promising perspectives for the treatment of various diseases.…”