Current progress in the hypoglycemic mechanisms of natural polysaccharides

Tang, Chao; Zhou, Ruizheng; Cao, Kexin; Li, Jun; Liu, Jun; Qian, Chunlu; Jin, Changhai

doi:10.1039/d3fo00991b

Cited by 16 publications

(2 citation statements)

References 169 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxidative stress has become one of the main problems of the modern, unhealthy lifestyle, being involved in the development of several chronic diseases, such as atherosclerosis, diabetes, and cancer [342][343][344][345][346][347]. Accumulation of reactive oxygen species (ROS) activates the pro-inflammatory and pro-apoptotic pathways by triggering uncontrolled reactions with proteins, lipids, and DNA [347].…”

Section: Antioxidant Peptidesmentioning

confidence: 99%

Diversity of Bioinspired Hydrogels: From Structure to Applications

Lupu¹,

Grădinaru²,

Gradinaru

et al. 2023

Gels

View full text Add to dashboard Cite

Hydrogels are three-dimensional networks with a variety of structures and functions that have a remarkable ability to absorb huge amounts of water or biological fluids. They can incorporate active compounds and release them in a controlled manner. Hydrogels can also be designed to be sensitive to external stimuli: temperature, pH, ionic strength, electrical or magnetic stimuli, specific molecules, etc. Alternative methods for the development of various hydrogels have been outlined in the literature over time. Some hydrogels are toxic and therefore are avoided when obtaining biomaterials, pharmaceuticals, or therapeutic products. Nature is a permanent source of inspiration for new structures and new functionalities of more and more competitive materials. Natural compounds present a series of physico-chemical and biological characteristics suitable for biomaterials, such as biocompatibility, antimicrobial properties, biodegradability, and nontoxicity. Thus, they can generate microenvironments comparable to the intracellular or extracellular matrices in the human body. This paper discusses the main advantages of the presence of biomolecules (polysaccharides, proteins, and polypeptides) in hydrogels. Structural aspects induced by natural compounds and their specific properties are emphasized. The most suitable applications will be highlighted, including drug delivery, self-healing materials for regenerative medicine, cell culture, wound dressings, 3D bioprinting, foods, etc.

show abstract

Section: Antioxidant Peptidesmentioning

confidence: 99%

Diversity of Bioinspired Hydrogels: From Structure to Applications

Lupu¹,

Grădinaru²,

Gradinaru

et al. 2023

Gels

View full text Add to dashboard Cite

show abstract

“…The treatment of diabetes often requires a variety of drugs that may be associated with various side effects. Natural products and their functional ingredients have become effective adjuncts to glucose-lowering therapy due to their advantages in lowering blood glucose levels and alleviating diabetic complications [18]. Compared to drug treatments, natural products are safer, have fewer toxicities and side effects, and can be used as dietary supplements [19].…”

Section: Introductionmentioning

confidence: 99%

Effects of Mulberry Leaf Fu Tea on the Intestines and Intestinal Flora of Goto-Kakizaki Type 2 Diabetic Rats

Liu,

Zeng,

Jiang

et al. 2023

Foods

View full text Add to dashboard Cite

Type 2 diabetes mellitus is a disease caused by hyperglycemia, an imbalance in the intestinal flora and disruption of the endocrine system. At present, it is primarily controlled through drug treatment and an improved diet. Mulberry leaf and fu brick tea were considered to have excellent hypoglycemic effects. This study used mulberry leaves and fu brick tea as raw materials to develop a dietary regulator that can assist in the prevention and alleviation of diabetes. The experiment used the Goto-Kakizaki (GK) rat model to investigate the hypoglycemic effect of mulberry leaf fu tea (MFT) and its influence on the intestinal flora of diabetic rats through methods including ELISA, tissue section observation and 16S RNA microbial sequencing. The results showed that, compared with the GK group, the intervention of mulberry leaf fu tea significantly reduced the activities of α-glucosidase (p < 0.05) and α-amylase (p < 0.05) in the duodenum of GK diabetic rats. The height of the duodenal villi was significantly reduced (p < 0.001), leading to decreased intestinal sugar absorption. At the same time, MFT alleviates the imbalance of intestinal flora caused by high blood sugar, promotes the growth of beneficial bacteria (Lactobacillus, Bifidobacterium, etc.), and inhibits the reproduction of harmful bacteria (Blautia, Klebsiella, Helicobacter, Alistipes, etc.). MFT helps reduce the secretion of toxic substances (lipopolysaccharide, p < 0.001), decreases oxidative stress and inflammation, mitigates organ damage, and improves symptoms of diabetes. Finally, the random blood glucose value of GK rats dropped from 22.79 mmol/L to 14.06 mmol/L. In summary, mulberry leaf fu tea can lower sugar absorption in diabetic rats, reduce the body’s oxidative stress and inflammatory response, regulate intestinal flora, and reduce blood sugar levels in GK rats. It is hinted that mulberry leaf fu tea could be used as a functional drink to help prevent the occurrence of diabetes.

show abstract

Structural characteristics of neutral polysaccharides purified from coix seed and its anti‐insulin resistance effects on HepG2 cells

Wu,

Liu,

Wang

et al. 2024

Food Science & Nutrition

View full text Add to dashboard Cite

Coix seed is recognized as a functional medicinal food due to its valuable biological activities, with polysaccharides being the primary active compounds. In this study, an ultrasonic‐assisted enzymatic extraction technique was employed, and response surface methodology was used to optimize the yield of polysaccharides to 9.55 ± 0.26%. A novel neutral polysaccharide, CSPsN‐1, was purified with a molecular weight of 7.75 kDa. CSPsN‐1 was composed of arabinose, galactose, glucose, xylose, and mannose in molar ratios of 0.48: 7.92: 86.39: 2.42: 2.79. Its backbone composed of →4)‐α‐D‐Glcp‐(1→ and →3,4)‐α‐D‐Glcp‐(1→ units, with terminal residues of α‐D‐Glcp. In vitro experiments, CSPsN‐1 enhanced glucose consumption in insulin‐resistant HepG2 cells and upregulated GLUT4 expression by activating the PI3K/AKT signaling pathway. These findings suggest that CSPsN‐1 holds significant promise as a functional ingredient for treating insulin resistance and related metabolic disorders.

show abstract

Current progress in the hypoglycemic mechanisms of natural polysaccharides

Abstract: Unhealthy dietary patterns-induced type 2 diabetes mellitus poses a great threat to human health all over the world. Accumulating evidence has revealed that the pathophysiology of type 2 diabetes mellitus...

Cited by 16 publications

References 169 publications

Diversity of Bioinspired Hydrogels: From Structure to Applications

Diversity of Bioinspired Hydrogels: From Structure to Applications

Effects of Mulberry Leaf Fu Tea on the Intestines and Intestinal Flora of Goto-Kakizaki Type 2 Diabetic Rats

Structural characteristics of neutral polysaccharides purified from coix seed and its anti‐insulin resistance effects on HepG2 cells

Contact Info

Product

Resources

About