Current research advances in microRNA-mediated regulation of Krüppel-like factor 4 in cancer: a narrative review

Yang, Xi; Chen, Cheng; Li, Li; Xiao, Tian; Zou, Yongdong; Zheng, Duo

doi:10.21037/atm-21-2347

Cited by 3 publications

(2 citation statements)

References 74 publications

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“…High expression levels and low free energy are important factors for adding scores. In addition, we hypothesized that too many target molecules of miRNA would reduce the biological functional strength of miRNAs, so the number of target molecules is negatively correlated with miRNA scoring (Yang et al, 2021). In our ceRNA network, 9 miRNAs targeted CX3CR1, and these 9 miRNAs were scored based on expression, binding free energy and number of targets comprehensively (Table 2).…”

Section: The Chemokine Cx3cr1 Is Regulated By Circrna-mirnamentioning

confidence: 99%

Circular RNA network plays a potential antiviral role in the early stage of JEV infection in mouse brain

Chen,

Kang,

Zhang

et al. 2024

Front. Microbiol.

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Japanese encephalitis is one of the most important insect-borne infectious disease with public health concern. The virus can break the blood–brain barrier and cause death or long-term sequela in infected humans or animals. Viral encephalitis is an important clinical feature of JEV infection. In recent studies, CircRNAs and related ceRNAs data illustrated the regulative role in many aspects of biological process and disease duration. It is believed that CircRNA regulates JEV infection in a ceRNA-dependent mechanism. In this study, brain tissues of experimental mice were sequenced and analysised. 61 differentially expressed circRNAs, 172 differentially expressed miRNAs and 706 differentially expressed mRNAs were identified by RNA-Sequencing and statistical analysis. CX3CR1 was determined as a key host factor impact JEV infection by microRNA interference measurement. CX3CR1 interaction network indicated circStrbp/miR709/CX3CR1 as a functional regulation axis. Further sequencing in BV2 cell shown CX3CR1 is a special target of miR-709 only during JEV infection. In summary, our study presented a new ceRNA pathway that impact JEV infection in vivo and in vitro, which could be a therapeutic target to fight against JEV.

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Section: The Chemokine Cx3cr1 Is Regulated By Circrna-mirnamentioning

confidence: 99%

Circular RNA network plays a potential antiviral role in the early stage of JEV infection in mouse brain

Chen,

Kang,

Zhang

et al. 2024

Front. Microbiol.

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“…All transformations were carried out by adapting protocols previously described (Chen et al, 2021). PiggyBac donor plasmid (300 ng/μl; piggyBac [AE_CA6CC3]) that contains an enhanced green fluorescent protein (eGFP) transformation marker driven by the Ae.…”

Section: Mosquito Transformationsmentioning

confidence: 99%

Transmission and Infection of Arboviruses

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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The molecular features of lung cancer stem cells in dedifferentiation process-driven epigenetic alterations

Masciale,

Banchelli,

Grisendi

et al. 2024

Journal of Biological Chemistry

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Current research advances in microRNA-mediated regulation of Krüppel-like factor 4 in cancer: a narrative review

Cited by 3 publications

References 74 publications

Circular RNA network plays a potential antiviral role in the early stage of JEV infection in mouse brain

Circular RNA network plays a potential antiviral role in the early stage of JEV infection in mouse brain

Transmission and Infection of Arboviruses

The molecular features of lung cancer stem cells in dedifferentiation process-driven epigenetic alterations

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