Current research on hyaluronic acid-drug bioconjugates

Zhang, Haiqun; Huang, Siling; Yang, Xiaoye; Zhai, Guangxi

doi:10.1016/j.ejmech.2014.08.067

Cited by 42 publications

(23 citation statements)

References 82 publications

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“…Because of its affinity to the widely distributed and, more importantly, tumorover-expressed CD44 receptor, HA has undergone extensive research in cancer treatment. To this end, HA's biocompatibility, non-immunogenicity and hydrophilicity have significantly promoted research in developing nanocarriers that actively target drugs and genes against tumor cells, while minimizing potential side effects [57,73].…”

Section: Ha Targeting To Cd44mentioning

confidence: 99%

Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine

Mattheolabakis

Milane

Singh

et al. 2015

Journal of Drug Targeting

474

310

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Cluster of differentiation-44 (CD44) is a ubiquitously present glycoprotein on the surface of mammalian cells that plays a significant role in a number of biological functions. Since the discovery that the receptor is over-expressed in a variety of solid tumors, such as pancreatic, breast and lung cancer, many studies have focused on methods for targeting CD44 in an attempt to improve drug delivery and discrimination between healthy and malignant tissue, while reducing residual toxicity and off-target accumulation. In this review, we describe CD44 receptor biology and its involvement in the different stages of tumor growth and metastasis, as well as methods currently used for targeting the receptor. Hyaluronic acid, the primary CD44 binding molecule, has proved a significant ally in developing nanocarriers that demonstrate preferential tumor accumulation and increased cell uptake. We outline a number of research approaches from the current literature that take advantage of hyaluronic acid's targeting ability and describe the possible advantages for each approach. The value of CD44 targeting can be easily appreciated from the number of different approaches that have reached clinical trials.

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Section: Ha Targeting To Cd44mentioning

confidence: 99%

Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine

Mattheolabakis

Milane

Singh

et al. 2015

Journal of Drug Targeting

474

310

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“…and anti-inflammatory drugs like methotrexate, dexamethasone, methylprednisolone, etc. to achieve receptor-mediated endocytosis [8]. HA polymer has also been used in the treatment of osteoarthritis, in ocular and plastic surgery, and in tissue engineering.…”

Section: Hyaluronic Acidmentioning

confidence: 99%

“…Cumulative Nile Red release from PMEEECL-b-POCTCL micelle at room temperature, 37 (below LCST) and 40°C (above LCST) in PBS. Reprinted with permission from Ref [8]…”

mentioning

confidence: 99%

Encapsulating Wall Materials for Micro-/Nanocapsules

Vijeth¹,

Heggannavar²

2019

Microencapsulation - Processes, Technologies and Industrial Applications

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Wall materials play a vital role in the development of micro-/nanocapsules to protect the bioactive compounds against external factors. The encapsulation process and the type of polymers exert a direct impact on the development of bioactive micro-/nanocapsules, which greatly reflect in encapsulation efficiency, solubility, stability, surface permeability, and release profile of desired bioactive compounds. Among the polymers, biodegradable polymeric materials have been the focus for various applications in food, pharmaceutical, and cosmetic industries. Thus, this chapter focuses on different encapsulation techniques and the importance of biodegradable polymers employed as wall materials for developing stable and safe micro-/nanocapsules. Among the natural polymers, protein-and polysaccharide-based polymers are widely used. Similarly, the most commonly used synthetic polymers are polycaprolactone, poly(lactic-co-glycolic acid), and polyethylene glycol. Synthetic polymers have been classified based on their exogenous and endogenous responsive natures. At the end, we have also discussed on the applications of biodegradable polymers employed in the development of micro-/ nanocapsules. To compile this chapter and to provide adequate information to the readers, we have explored various sources, such as reviews, research articles, books, and book chapters including Google sites.

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“…Because of its many carbohydrate subunits, hyaluronic acid is able to absorb large quantities of water and has a gelly-like consistency. This unique biocharacteristic gives it the capacity to lubricate movable parts of the body (muscles, joints) [21].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine

Vasile¹,

Iancu²,

Bogdănici³

et al. 2017

Rev. Chim.

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Hyaluronic acid is a mucopolysaccharide encountered in most body fluids and extracellular matrix. The aim of our review is to summarize current evidence about chemico-physical properties of hyaluronic acid, highlighting biomedical applications of hyaluronan derivatives. It is a glycosaminoglycan made of repeating disaccharide units containing a carboxylate group, four hydroxyl groups and one carboxylate group, with hydrophilic properties. Its particular structure with multiple coils forming an entangled network results in unique pseudoplastic and viscoelastic characteristics. Its viscous and elastic behavior, depending on the applied strain, makes hyaluronan widely applicable in biomedical field. The large amount of functions and applications is determined by the physico-chemical properties, which allows a polymorphism of the hyaluronic acid structures depending on the molecular weight variations, concentration and ionic status. It is currently used in ophthalmology, orthopedics and rheumatology, in plastic surgery, surgery and otolaryngology as well. Already widely used in clinical practice, hyaluronic acid proves to be often the best solution for difficult medical problems. Future developments in nanomedicine and drug delivery linked to hyaluronic acid are emerging.

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Current research on hyaluronic acid-drug bioconjugates

Cited by 42 publications

References 82 publications

Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine

Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine

Encapsulating Wall Materials for Micro-/Nanocapsules

Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine

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