Current research on pediatric patients with bronchiolitis obliterans in Brazil

Tomikawa, Silvia Onoda; Rodrigues, Joaquim Carlos

doi:10.5582/irdr.2014.01020

Cited by 6 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adenovirus infection accounted for 4% − 10% (3) of the pathogens causing pneumonia in children. About 20% − 50% of the patients still had respiratory complications after adenovirus pneumonia treatment (1) , such as bronchiolitis obliterans (4) , bronchiectasis, hyperlucenct lung, pleurisy, atelectasis, chronic pneumonia, unilateral (4) clear lung syndrome, etc. The most common werebronchiolitis obliterans (BO) and recurrent asthma Interest.…”

Section: Discussionmentioning

confidence: 99%

Bronchiolitis obliterans after severe adenovirus pneumonia:a review of 46 cases

Lan¹,

Yu²,

Lin³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background:This study aimed to investigate the risk factors of bronchiolitis obliterans caused by severe adenovirus pneumonia. Methods: The First Affiliated Hospital of Xiamen University in January, 2019 was collected The clinical data of 229 children with severe adenovirus pneumonia from January to January 2020 were divided into obliterative bronchiolitis group (BO group) and non obstructive bronchiolitis group (non BO group) according to the follow-up clinical manifestations and imaging data. The clinical data, laboratory examination and imaging data of the children were retrospectively analyzed. Results: Among 229 children with severe adenovirus pneumonia, 46 cases were in BO group. The number of days of hospitalization, oxygen consumption time, LDH, IL-6, AST, D-dimer and hypoxemia in BO group were significantly higher than those in non BO group; The difference was statistically significant (P < 0.05). Univariate logistic regression analysis showed that there were significant differences in the blood routine neutrophil ratio, platelet level, Oxygen supply time, hospitalization days, AST level, whether there was hypoxemia, timing of using hormone, more than two bacterial feelings were found in the two groups, levels of LDH, albumin and Scope of lung imaging (P < 0.05). Conclusions: The related risk factors of BO caused by severe adenovirus pneumonia were long hospitalization days and oxygen consumption time, elevated platelet levels, AST and LDH levels in laboratory tests, and more than two kinds of bacterial infections, double lung involvement, and hypoxemia. Early use of glucocorticoid had a significant effect on reducing the formation of BO.

show abstract

Section: Discussionmentioning

confidence: 99%

Bronchiolitis obliterans after severe adenovirus pneumonia:a review of 46 cases

Lan¹,

Yu²,

Lin³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Bronchiolitis obliterans is observed rarely in children, but its frequency is not known clearly ( 14 , 15 ). It mostly develops as a result of infections caused by agents such as adenovirus, influenza, and mycoplasma pneumonia, but a certain part of the cases develop as a result of bone marrow transplantation (BMT), lung transplantation, toxic gas inhalation or gastroesophageal reflux ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

“…Various publications have reported that pulmonary functions can remain stable and even improve with favorable control in cases of bronchiectasis ( 23 – 25 ). In bronchiolitis obliterans, improvement may be observed in the clinical picture and pulmonary functions after a 2–3-year follow-up ( 15 , 26 ). In a study conducted by Zhang et al ( 27 ), clinical improvement was observed with a rate of 22.6%.…”

Section: Discussionmentioning

confidence: 99%

Atipik Hışıltılı Çocuklarda Erken Tanı Prognozu Etkilemektedir

et al. 2019

View full text Add to dashboard Cite

Aim: Recurrent wheezing is a common problem in preschool children. It is classified into two groups because there can be many reasons for wheeze: typical and atypical. The aim of this study was to identify the general features of atypical wheezy children. Material and Methods: Three hundred two children who presented to our clinic between 2000 and 2015 for three or more wheezing attacks and were diagnosed as having an underlying disease such as bronchiectasis, foreign body aspiration, recurrent aspiration pneumonia, cystic fibrosis, bronchopulmonary dysplasia, congenital anomalies, and tuberculosis, were included in the study. Results: In this study, 127 (42.1%) girls and 175 (57.9%) boys were evaluated. The diagnostic distribution of the patients was as follows: bronchopulmonary dysplasia (21.9%), bronchiolitis obliterans (16.6%), bronchiectasis (14.5%), bronchiolitis obliterans + primary immunodeficiency (12.3%), cystic fibrosis (10.3%), bronchiectasis + primary immunodeficiency (7.9%), recurrent aspiration pneumonia (3.6%) and foreign body aspiration (3.3%), and other diseases (9.6%). Mosaic oligemia, bronchiectasis, atelectasis, bronchiolectasis, and small airway disease were the most distinct findings on high-resolution lung tomography. When the patients were evaluated clinically, radiologically, and according to pulmonary functions after an average period of 40 months, it was seen that 9.2% deteriorated, 33.9% regressed, and 56.7% remained stable. Presentation to hospital after the first attack occurred earlier in patients with bronchopulmonary dysplasia, bronchiolitis obliterans and bronchiolitis obliterans + primary immunodeficiency compared with patients with bronchiectasis, bronchiectasis + primary immunodeficiency, and cystic fibrosis. When presentation time and outcomes were evaluated, it was found that 63.4% of patients who presented to hospital early (0–6 months) and 7.5% of patients who presented late (after 5 years) had regression. Conclusion: Recurrent wheezy children must be promptly evaluated for an underlying disease. Early diagnosis and treatment influence the prognosis.

show abstract

“…Bronchiolitis obliterans (BO), also known as constrictive bronchiolitis, is a chronic airflow obstruction syndrome associated with inflammatory injury of small airways and belongs to a rare, fatal, and irreversible obstructive pulmonary disease that manifests as bronchiolar narrowing or obstruction due to inflammation or fibrosis [ 1 , 2 ]. Since BO is usually caused by secondary respiratory tract infection, of which the more common is viral infection, and adenovirus is predominant, the disease is also used to specifically refer to a severe subtype of bronchiolitis in children caused by adenovirus or is considered to be a pulmonary manifestation in the chronic phase of transplant rejection [ 3 , 4 ]. The main clinical characteristics of the disease are recurrent or persistent shortness of breath, wheezing or coughing, poor motor ability, and fine rales and wheezing in the lungs [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Artificial Intelligence Algorithm‐Based High‐Resolution Computed Tomography Image in the Treatment of Children with Bronchiolitis Obliterans by Traditional Chinese Medicine Method of Resolving Phlegm and Removing Blood Stasis

Shi

Zhou

2022

Contrast Media & Molecular Imaging

View full text Add to dashboard Cite

This research was aimed to explore the application of high-resolution computed tomography (HRCT) based on intelligent iterative reconstruction technique in the early diagnosis and treatment of bronchiolitis obliterans (BO) in children and to explore the efficacy of traditional Chinese medicine (TCM) in resolving phlegm and removing blood stasis. Sixty pediatric patients with BO were selected as the study subjects and diagnosed by HRCT scanning, and the scanned images were processed by iterative reconstruction technique. The patients were treated with TCM therapy of resolving phlegm and removing blood stasis alone (group A), HRCT-guided TCM therapy of resolving phlegm and removing blood stasis (group B), and iterative reconstruction HRCT-guided TCM therapy of resolving phlegm and removing blood stasis (group C). The results showed that the lung HRCT image after iterative reconstruction was closer to the original image than that after filtered back projection reconstruction, and the edge of the image after filtered back projection reconstruction was more blurred and the noise was higher. The image obtained by iterative reconstruction technique was smoother and clearer, and the image stability after iterative reconstruction was higher. The treatment results showed that the proportion of moderate and severe obstruction in group C was 5.18%, which was significantly lower than that in group A (18.75%) and group B (11.29%), and group B was significantly lower than that in group A (18.75%) ( P < 0.05 ). The proportion of clinical effect in group C after treatment was 70.18%, significantly higher than that in group A (55.5%) and group B (63.34%), and that in group B was significantly higher than that in group A (55.5%) ( P < 0.05 ). In summary, the lung HRCT after iterative reconstruction can more clearly and intuitively show the lesion site, which has a key role in guiding the early diagnosis and treatment planning of BO; the HRCT image based on iterative reconstruction technique combined with TCM treatment of removing blood stasis and resolving phlegm has a better therapeutic effect on children, with a high application value.

show abstract

Current research on pediatric patients with bronchiolitis obliterans in Brazil

Cited by 6 publications

References 23 publications

Bronchiolitis obliterans after severe adenovirus pneumonia:a review of 46 cases

Bronchiolitis obliterans after severe adenovirus pneumonia:a review of 46 cases

Atipik Hışıltılı Çocuklarda Erken Tanı Prognozu Etkilemektedir

Artificial Intelligence Algorithm‐Based High‐Resolution Computed Tomography Image in the Treatment of Children with Bronchiolitis Obliterans by Traditional Chinese Medicine Method of Resolving Phlegm and Removing Blood Stasis

Contact Info

Product

Resources

About