Current research status of HLA in immune‐related diseases

Liu, Bingnan; Shao, Yuanyuan; Fu, Rong

doi:10.1002/iid3.416

Cited by 45 publications

(50 citation statements)

References 93 publications

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“…Third, TLR4 initiated signaling is involved in the regulation of osteoblast differentiation and function [ 32 , 34 ]. Several such immunoregulatory mediators are also included in an osteoblast-specific protein–protein interaction network (see Figure 2 ; CD14, TANK, TRAF6) together with immunoregulatory HLA molecules [ 36 ]. Thus, our osteoblast-specific protein interaction network seems to be involved in a crosstalk between osteoblasts and regulators of inflammation/immunity.…”

Section: Discussionmentioning

confidence: 99%

Proteomic Comparison of Bone Marrow Derived Osteoblasts and Mesenchymal Stem Cells

Aasebø

Brenner

Hernandez-Valladares

et al. 2021

IJMS

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Mesenchymal stem cells (MSCs) can differentiate into osteoblasts, and therapeutic targeting of these cells is considered both for malignant and non-malignant diseases. We analyzed global proteomic profiles for osteoblasts derived from ten and MSCs from six healthy individuals, and we quantified 5465 proteins for the osteoblasts and 5420 proteins for the MSCs. There was a large overlap in the profiles for the two cell types; 156 proteins were quantified only in osteoblasts and 111 proteins only for the MSCs. The osteoblast-specific proteins included several extracellular matrix proteins and a network including 27 proteins that influence intracellular signaling (Wnt/Notch/Bone morphogenic protein pathways) and bone mineralization. The osteoblasts and MSCs showed only minor age- and sex-dependent proteomic differences. Finally, the osteoblast and MSC proteomic profiles were altered by ex vivo culture in serum-free media. We conclude that although the proteomic profiles of osteoblasts and MSCs show many similarities, we identified several osteoblast-specific extracellular matrix proteins and an osteoblast-specific intracellular signaling network. Therapeutic targeting of these proteins will possibly have minor effects on MSCs. Furthermore, the use of ex vivo cultured osteoblasts/MSCs in clinical medicine will require careful standardization of the ex vivo handling of the cells.

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Section: Discussionmentioning

confidence: 99%

Proteomic Comparison of Bone Marrow Derived Osteoblasts and Mesenchymal Stem Cells

Aasebø

Brenner

Hernandez-Valladares

et al. 2021

IJMS

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“…2.2.5. Human Leukocyte Antigen-Major Histocompatibility Complex, DR, B1 (HLA-DRB1) HLA-DR is a major histocompatibility complex (MHC) class II cell receptor encoded on chromosome 6 region 6p21.31 [81]. It serves as a ligand for the T-cell receptor (TCR) and is involved in multiple autoimmune conditions.…”

Section: Lymphotoxin α (Lt-α) or Transforming Growth Factor β (Tgf-β) And Interferon γ (Ifn-γ)mentioning

confidence: 99%

Genetic Susceptibility to Acute Kidney Injury

Ortega-Loubón

Martínez-Paz

García‐Morán

et al. 2021

JCM

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Acute kidney injury (AKI) is a widely held concern related to a substantial burden of morbidity, mortality and expenditure in the healthcare system. AKI is not a simple illness but a complex conglomeration of syndromes that often occurs as part of other syndromes in its wide clinical spectrum of the disease. Genetic factors have been suggested as potentially responsible for its susceptibility and severity. As there is no current cure nor an effective treatment other than generally accepted supportive measures and renal replacement therapy, updated knowledge of the genetic implications may serve as a strategic tactic to counteract its dire consequences. Further understanding of the genetics that predispose AKI may shed light on novel approaches for the prevention and treatment of this condition. This review attempts to address the role of key genes in the appearance and development of AKI, providing not only a comprehensive update of the intertwined process involved but also identifying specific markers that could serve as precise targets for further AKI therapies.

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“…Single nucleotide polymorphisms (SNPs) of immune-related genes contribute to the onset of disorders and immune reactivity 7 . Previous studies by Petersdorf et al revealed that the rs2242656 of BAG6, rs986522 of COL11A2, rs2244546 of HCP5, rs2523957 of MICD, rs429916 of HLA-DOA, rs2071479 of HLA-DOB, rs107822 of RING1, and rs209130 of TRIM27 are related to the risk of relapse, survival rate, or graft-versus-host disease (GVHD) in patients receiving bone marrow stem cell transplantation 8 .…”

Section: Introductionmentioning

confidence: 99%

Single nucleotide polymorphisms within HLA region are associated with the outcomes of unrelated cord blood transplantation

Chen

Chang

Jaing

et al. 2021

Sci Rep

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Cord blood transplantation (CBT) provides a treatment scheme for hematologic diseases and leukemia in both children and adults. However, adverse reactions and transplantation-related death may still occur in patients receiving CBT even when donor and recipient have fully matched HLA in high-resolution HLA typing analysis. Single nucleotide polymorphisms (SNPs) of HLA-related and unrelated genes are known to associate with disease status of patients with unrelated stem cell transplantation. In this study, the genomic regions ranging from 500 base pairs upstream to 500 base pairs downstream of the eight SNPs that were reported as transplantation determinants by Petersdorf et al. were analyzed to evaluate whether genetic variants were associated with the survival status of patients, and the risk for severe (grades 3–4) graft-versus-host disease (GVHD) or cytomegalovirus (CMV) infection/reactivation. The analyses were performed in the mode of recipient genotype, donor genotype, and recipient-donor mismatching, respectively. By analysis of sixty-five patients and their HLA-matched unrelated donors, we found that five SNPs were associated with patient survival which included the recipient genotype with SNPs of rs107822 in the RING1 gene, and rs2070120, rs17220087 and rs17213693 in the HLA-DOB gene; and the recipient-donor mismatching with SNPs of rs9282369 in HLA-DOA gene, and rs2070120, rs17220087 and rs17213693 in the HLA-DOB gene. Five SNPs were associated with the risk for severe GVHD which included the donor genotype with SNPs of rs213210 and rs2523675; the recipient genotype with SNPs of rs9281491 in the HCP5 gene; and the recipient-donor mismatching with SNPs of rs209130 in the TRIM27 gene, and rs986522 in the COL11A2 gene. Six SNPs were related to the risk for CMV infection/reactivation which included the donor genotype with SNPs of rs435766, rs380924, and rs2523957; and the recipient-donor mismatching with SNPs of rs2070120, rs17220087, and rs17213693 in the HLA-DOB gene; and rs435766 and rs380924 in the MICD gene. This study provides the basis for larger analyses and if the results are confirmed, a way of selecting better unrelated CBT candidate donors.

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Current research status of HLA in immune‐related diseases

Cited by 45 publications

References 93 publications

Proteomic Comparison of Bone Marrow Derived Osteoblasts and Mesenchymal Stem Cells

Proteomic Comparison of Bone Marrow Derived Osteoblasts and Mesenchymal Stem Cells

Genetic Susceptibility to Acute Kidney Injury

Single nucleotide polymorphisms within HLA region are associated with the outcomes of unrelated cord blood transplantation

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