Current role of neuromodulation in bladder pain syndrome/interstitial cystitis

Padilla‐Fernández, Bárbara; Hernández-Hernández, David; Castro-Díaz, David

doi:10.1177/17562872221135941

Cited by 9 publications

(8 citation statements)

References 49 publications

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“…Neuromodulation has not been FDA-approved as a treatment for IC/BPS but has recently been clinically approved for select patients who have success in a nerve stimulation trial ( Clemens et al, 2022b ). Neuromodulation can lead to control over urinary symptoms through the emission of electrical stimulation that targets nerve activity due to bladder filling ( Intern ational Neuromodulation Society, 2013 ; Padilla-Fernandez et al, 2022 ). There are two main neuromodulation techniques that are currently being explored to treat IC/BPS; sacral nerve stimulation and pudendal nerve stimulation ( Clemens et al, 2022b ; Padilla-Fernandez et al, 2022 ).…”

Section: Current Available Treatment For Ic/bpsmentioning

confidence: 99%

“…Both sacral and pudendal nerve stimulation has been shown to improve urinary symptoms, including bladder capacity, urinary frequency, voided volume, nocturia and pain ( Peters et al, 2007 ; Clemens et al, 2022b ; Padilla-Fernandez et al, 2022 ). However, only a small number of patients have been studied and there is a lack of evidence to suggest that neuromodulation is effective for long periods of time.…”

Section: Current Available Treatment For Ic/bpsmentioning

confidence: 99%

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Animal models of interstitial cystitis/bladder pain syndrome

Tay,

Grundy

2023

Front. Physiol.

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Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic disorder characterized by pelvic and/or bladder pain, along with lower urinary tract symptoms that have a significant impact on an individual’s quality of life. The diverse range of symptoms and underlying causes in IC/BPS patients pose a significant challenge for effective disease management and the development of new and effective treatments. To facilitate the development of innovative therapies for IC/BPS, numerous preclinical animal models have been developed, each focusing on distinct pathophysiological components such as localized urothelial permeability or inflammation, psychological stress, autoimmunity, and central sensitization. However, since the precise etiopathophysiology of IC/BPS remains undefined, these animal models have primarily aimed to replicate the key clinical symptoms of bladder hypersensitivity and pain to enhance the translatability of potential therapeutics. Several animal models have now been characterized to mimic the major symptoms of IC/BPS, and significant progress has been made in refining these models to induce chronic symptomatology that more closely resembles the IC/BPS phenotype. Nevertheless, it's important to note that no single model can fully replicate all aspects of the human disease. When selecting an appropriate model for preclinical therapeutic evaluation, consideration must be given to the specific pathology believed to underlie the development of IC/BPS symptoms in a particular patient group, as well as the type and severity of the model, its duration, and the proposed intervention’s mechanism of action. Therefore, it is likely that different models will continue to be necessary for preclinical drug development, depending on the unique etiology of IC/BPS being investigated.

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Section: Current Available Treatment For Ic/bpsmentioning

confidence: 99%

Section: Current Available Treatment For Ic/bpsmentioning

confidence: 99%

Animal models of interstitial cystitis/bladder pain syndrome

Tay,

Grundy

2023

Front. Physiol.

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“…Selective pudendal nerve stimulation has a high response rate when pudendal neuralgia is suspected. 40…”

Section: Physiotherapymentioning

confidence: 99%

A Bibliometric Analysis of Urologic Chronic Pelvic Pain Syndrome From 2000 to 2022

Wang¹,

Cao²,

Lin³

et al. 2023

JPR

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Urologic chronic pelvic pain syndrome has attracted a lot of attention in the new century, and an increasing number of relevant studies have been published. Therefore, we performed a bibliometric analysis of these publications, hoping to show the current research hotspots and future research trends. Methods: The articles on were selected from the Web of Science Core Collection. Countries, authors, references and keywords in the field were visualized and analyzed using CiteSpace and VOSViewer software. Results: A total of 1014 articles on urologic chronic pelvic pain syndrome were identified, with "chronic pelvic pain syndrome" being the most common keyword, with a strong association with "interstitial cystitis" and "chronic prostatitis". The hotspot of urologic chronic pelvic pain syndrome research has gradually shifted from chronic prostatitis / urologic chronic pelvic pain syndrome to cystitis/bladder pain syndrome over the past few years. Future research tends to focus on urologic chronic pelvic pain syndrome etiology, including oxidative stress and inflammation. Conclusion:Research on urologic chronic pelvic pain syndrome is steadily growing. The United States has made the most prominent contribution in this area, and the share of China's contribution is expected to grow further. The etiology of urologic chronic pelvic pain syndrome, including inflammation and oxidative stress, have been the focus of current research and developmental trends in the future research.

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“…Secondly, neuromodulation is hypothesized to induce functional changes in higher brain centres and by doing so controls descending feedback from the brainstem and other regions to the sacral spinal cord. However, the precise mechanism is not yet fully clarified and further research is needed [ 4 – 6 ].…”

Section: Summary Of Current Understandingmentioning

confidence: 99%

“…As the pudendal nerve originates from the S2 through S4 nerve root, this also forms a target nerve for neuromodulation. The pudendal nerve has a great amount of afferent nerve fibres and plays a role in innervation of the pelvic floor alongside the external urethral and anal sphincter [ 6 ].…”

Section: Pudendal Neuromodulationmentioning

confidence: 99%

Current position of neuromodulation for bladder pain syndrome/interstitial cystitis

Kendall,

Schrijvers,

Heesakkers

2023

Current Opinion in Urology

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Purpose of review Despite established effectiveness in overactive bladder and nonobstructive retention, neuromodulation's application in interstitial cystitis/bladder pain syndrome (IC/BPS) remains a topic of ongoing research. The purpose of this article is to review recent developments in neuromodulation as treatment of IC/BPS offering guidance for healthcare practitioners dealing with IC/BPS cases. Recent findings Recent research underlines the promising role of sacral, tibial and pudendal neuromodulation in management of IC/BPS symptoms. Studies reveal encouraging outcomes, particularly in alleviating urgency and frequency symptoms. However, while urgency and frequency symptoms tend to improve, comprehensive pain relief remains a challenge. Percutaneous tibial nerve stimulation (PTNS) and transcutaneous tibial nerve stimulation (TTNS) stand out due to their minimal invasive nature. Existing literature points to the need for larger prospective studies with extended follow-up periods to validate the efficacy and sustainability of neuromodulation. Summary Neuromodulation is a promising treatment modality for refractory IC/BPS. Due to the minimal invasive nature, they should be tried before rigorous surgery. However, the limited quantity of available data and the variability in pain relief outcomes necessitate cautious interpretation. The review emphasizes the need for further research.

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Current role of neuromodulation in bladder pain syndrome/interstitial cystitis

Cited by 9 publications

References 49 publications

Animal models of interstitial cystitis/bladder pain syndrome

Animal models of interstitial cystitis/bladder pain syndrome

A Bibliometric Analysis of Urologic Chronic Pelvic Pain Syndrome From 2000 to 2022

Current position of neuromodulation for bladder pain syndrome/interstitial cystitis

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