Current Scenario of the Pandemic Covid-19: An Overview

Abstract

The novel coronavirus disease-19 (COVID-19) caused by the SARS-CoV-2 is an emerging disease with deadly consequences, extended its stride over the globe commenced from the epicenter, Wuhan wet market, China led to declare globally as pandemic disease. Several non-specific features of the disease like prolonged incubation period, asymptomatic yet contagious, longer illness duration, and conveyance post clinical recovery feature makes prevention difficult and is the key reason for its rapid spread across the world. Covid-19 shows varied manifestations with the majority of reported cases having mild or even no symptoms. However, the infection led to a destructive footprint in the pulmonary system, specifically, lungs are most prone to damage, making them incapable of conducting respiratory functions and thus, resulting in acute respiratory distress syndrome (ARDS), multi-organ dysfunction, and loss of life. Up to the present, there is no worldwide-approved treatment for COVID-19 and only repurposed drugs are employed for the hospitalized patient, necessitating an urgent need to develop effective therapeutics. Hence, effective control of disease spread through screening and isolation of contacts is crucial in the community. The contagion effect of the COVID-19 outbreak has brought major challenges to health systems as well as global economy worldwide. Development of rapid diagnostic test and effective vaccine as well as minimizing the exposure of the human population to possible animal reservoirs is measures needed to curb future impact. The outbreak of SARS-CoV in 2003 followed by MERS-CoV within a decade, indicates the threat of novel infectious diseases resulting from RNA viruses, will continue to present a serious global health threat, as epitomized by COVID-19. Therefore, this review is attempting to provide an overview of the current scenario of COVID-19 in terms of epidemiology, pathophysiology, diagnosis, prevention, and treatment, especially focusing on public health impact.

Molecular scaffolds from mother nature as possible lead compounds in drug design and discovery against coronaviruses: A landscape analysis of published literature and molecular docking studies

“…In 2002–2003, SARS-CoV-1 (unknown then) caused a serious epidemic of severe pulmonary disorder in human populations which spread to four continents [ 30 ]. 8096 persons got infected and it claimed life of 774 victims, creating a 10% mortality rate [ 31 ]. On epidemiological surveillance of the disease it was demonstrated that this novel coronavirus originated from bats, spread to raccoon dogs, Chinese ferret badgers and Himalayan palm civets at Guangdong wet markets, China [ 32 ].…”