Current source-density analysis of light-evoked field potentials in rabbit retina

Abstract

The technique of current source-density analysis was applied to several components of the light-evoked field potentials (electroretinogram) from the retina of the superfused eyecup of rabbit. The depth distributions of the major current sources and sinks were: b-wave--sink at outer plexiform layer, source at inner plexiform layer; M-wave--sink at inner plexiform layer, source at retinal surface; and slow PIII--source near outer plexiform layer, sink at retinal surface. These distributions, along with the sensitivities of these responses to certain pharmacological agents, support earlier studies that Müller cells generate the M-wave and slow PIII, but that depolarizing bipolar cells directly generate the b-wave.

Functionally intact glutamate-mediated signaling in bipolar cells of the TRKB knockout mouse retina

“…Since convincing data from several mammalian species now supports the hypothesis that the dark-adapted b-wave is generated by rod bipolar cells (Robson & Frishman, 1995, Green & Kapousta-Bruneau, 1999Karwoski & Xu, 1999;Lei & Perlman, 1999), our observations indicate that a functional defect exists in the rod bipolar cell signaling pathway at some point proximal to the locus of phototransduction in the rods. The present study pursues this point further.…”

Early Retinal Damage in Experimental Diabetes: Electroretinographical and Morphological Observations

“…These observations suggest that the photoreceptors are relatively resistant to the pathological processes of early diabetes compared to the generators of the bwave. The b-wave is believed to re¯ect light-induced electrical activity in the ON-center bipolar cells (Green and Kapousta-Bruneau, 1999;Karwoski and Xu, 1999;Lei and Perlman, 1999) and contributions of the Mu È ller cells (Ripps and Witkovsky, 1985). The ERG observations cannot separate diabetic-induced damage to the ON-center bipolar cells and/or to Mu È ller cells.…”

Revisiting visual dysfunctions in schizophrenia from the retina to the cortical cells: A manifestation of defective neurodevelopment

“…the bwave. Both of them are quantified with an amplitude and a latency (Brown, 1968;Green & Kapousta-Bruneau, 1999;Karwoski & Xu, 1999). The first observation of a decrease in b-wave amplitude in schizophrenia was reported in 1992 (Gerbaldo et al, 1992), but this finding was only observed in patients with a history of sun gazing and who showed an increased tolerance to extremely intense eye light exposure.…”