Current standards of care in bladder and prostate rhabdomyosarcoma

Kieran, Kathleen; Shnorhavorian, Margarett

doi:10.1016/j.urolonc.2015.12.012

Cited by 18 publications

(13 citation statements)

References 71 publications

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“…Embryonal RMS is the most common pathological type in pediatric bladder RMS and ERMS always indicates a better prognostic than non-embryonal RMS. This well-known phenomenon has been reported many times and was also validated in our study, only the percentage of ERMS (71.58%) is lower than former studies (about 90%) [17].…”

Section: Resultssupporting

confidence: 88%

“…The total ratio of male and female is about 2:1. It remains relatively stable in different age groups, which is not consistent with former research (about 75% arise in male) as they focused on the whole genitourinary RMS and the prostate RMS increased the proportion of male patients [17]. We con rmed that the gender was not associated with different survival time and was not a risk factor, As all SEER data were collected in the United States, this study was lack of global representation of race proportions.…”

Section: Resultscontrasting

confidence: 79%

“…They stratify patients into two risk-groups according their response to the chemotherapy and for the low risk group patients, their bladders could be salvaged. Kathleen Kieranc and Margarett Shnorhavorian [9]systematically summarized the epidemiology and treatment status of bladder/prostate rhabdomyosarcoma.…”

Section: Resultsmentioning

confidence: 99%

“…The majority of ERMS cases have an early onset and are always associated with better prognosis than ARMS [4]. As the incidence of bladder rhabdomyosarcoma is relative rare, most of the previous studies are single center case report or small samples cohort and mainly focused on the surgical treatment [5][6][7][8][9], except for the research conducted by the former Intergroup Rhabdomyosarcoma Study (IRS) Group and its successor Children's Oncology Group (COG) STS Committee [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Incidence and Survival Trends of Bladder Rhabdomyosarcoma:A SEER-based Analysis of 125 Cases

Пин¹,

Zhou²,

Hua-lin³

et al. 2020

Preprint

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Background To elucidate the bladder rhabdomyosarcoma clinicopathological characteristics and reveal the prognostic factors. Methods We screened data from SEER database (1975-2016) stratified by age group, evaluated the differences between groups with Chi-square and Fisher’s test, conducted the Kaplan-Meier survival analysis and plotted the survival curve. The significant factors were brought into Cox regression analysis and calculated the HR(95%CI). Results About half of the patients who develop bladder RMS will be younger than 2 years of age. Embryonal RMS account for 76% of all histopathology types. Age at diagnosis more than 16-y (HR=6.595,95%CI:3.62-12.01, p=7.04e-10), NOT embryonal rhabdomyosarcoma (HR=3.61, 95%CI:1.99-6.549, p =4.1e-06), without radiotherapy combined or surgery alone (HR=4.382, 95%CI:1.99-6.549, p =2.4e-05) and not performed the surgery (HR=2.982,95%CI:1.263-7.039, p =0.0126) were negatively correlated with 5-year survival time, while race( p =0.341), whether performed the lymphadenectomy( p =0.722) showed no influence on survival time. Cox regression results show that age, histology, SEER stage, treatment combined or alone influence the clinical outcomes. Conclusions We demonstrated the demographic and characteristic of bladder rhabdomyosarcoma, identified and excluded the prognostic factors for the 5-year overall survival and clinical outcomes.

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Section: Resultssupporting

confidence: 88%

Section: Resultscontrasting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence and Survival Trends of Bladder Rhabdomyosarcoma:A SEER-based Analysis of 125 Cases

Пин¹,

Zhou²,

Hua-lin³

et al. 2020

Preprint

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“…Rhabdomyosarcoma of the pelvic region is known to most commonly affect the urogenital tract as was the case in this study. [14] The outcome of surgical treatment is attended with both short and long term adverse outcomes. Studies in which male survivors of the surgical treatment of pelvic tumours were followed up showed that erectile function was remarkably affected in many cases.…”

Section: Discussionmentioning

confidence: 99%

Paediatric Pelvic Tumours; Presentation, Diagnosis and Challenges of Treatment in a Low Resource Setting

E¹,

Gracia²

2019

AJCPN

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Background: Paediatric pelvic solid tumours present peculiar challenge in clinical diagnosis due to their inherently obscure anatomic location, and the varied, often vague symptoms. Difficult surgical access and presence of important surrounding pelvic structures make their surgical treatment particularly challenging. Aim: To report our experience with paediatric pelvic solid tumours and to highlight the presentation pattern and challenges of diagnosis and treatment in our setting. Subjects and Methods: This is a five year retrospective study of pelvic solid tumours in children seen in our centre between December 2013 and November 2018. Data retrieved were demographics, presenting symptoms and duration, previous treatments, findings on examination, laboratory investigations, treatment given in our centre, histology of tumours and duration of follow up, outcome. Analysis was done on Microsoft Excel spread sheet Windows 2007. Results: Twenty three cases comprising 7 males and 16 females were included in this study. The age range was 1 to 14 years with a median at 6.5 years. Ten(43.5%) of these cases were benign, and 13(56.5%) were malignant. The teratomas comprised 9 benign cystic mature teratomas and 6 malignant teratomas. There were 4 mortalities and one recurrence. Conclusion: The anatomic location and vague early symptoms of pelvic tumours make early diagnosis difficult in our setting. High morbidity and mortality is the direct consequence. In a resource poor setting as ours, scrupulous physical examination including digital rectal examination is key to early diagnosis.

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