Current State and Future Perspectives on Gastroretentive Drug Delivery Systems

Tripathi, Julu; Thapa, P.; Maharjan, Ravi; Jeong, Seong Hoon

doi:10.3390/pharmaceutics11040193

Cited by 162 publications

(169 citation statements)

References 104 publications

(156 reference statements)

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“…-A low density system may be associated with problems such as sticking together or being obstructed in the GIT, which could produce gastric irritation [9]. -They require high fluid levels in the stomach to float and work effectively [20].…”

Section: Requirements Properties/how They Work Drawbacksmentioning

confidence: 99%

“…-Drugs with irritant effects on the gastric mucosa are not suitable candidates for low-density systems [5]. -In some cases, the release kinetics of the drug cannot be changed without changing the floating properties of the dosage form and vice versa [9].…”

Section: Requirements Properties/how They Work Drawbacksmentioning

confidence: 99%

“…They are also of interest for the formulations of drugs that are primarily absorbed in the stomach, such as amoxicillin [42]. However, as HBS is a matrix formulation, the release kinetics of the drug cannot be changed without changing the floating properties of the dosage form and vice versa [9].…”

Section: Hydrodynamic Balanced Systems (Hbs)mentioning

confidence: 99%

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In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

et al. 2020

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The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it difficult to achieve therapeutic levels in the organism; moreover, some drugs must act locally due to a gastric pathology, but the time they remain in the stomach is short. The use of formulations capable of improving all these parameters, as well as increasing the resident time in the stomach, has been the target of numerous research works, with low-density systems being the most promising and widely explored, however, there is further scope to improve these systems. There are a vast variety of polymeric materials used in low-density gastroretentive systems and a number of methods to improve the bioavailability of the drugs. This works aims to expedite the development of breakthrough approaches by providing an in-depth understanding of the polymeric materials currently used, both natural and synthetic, their properties, advantages, and drawbacks.

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Section: Requirements Properties/how They Work Drawbacksmentioning

confidence: 99%

Section: Requirements Properties/how They Work Drawbacksmentioning

confidence: 99%

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In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

et al. 2020

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“…due to this forming of gas bubbles of CO2 by incorporation of carbonates or bicarbonates, by contact with gastric region. [21] (…”

Section: Drug + Polymermentioning

confidence: 99%

“…Buoyancy increasing agent-For increasing or enhancing the buoyancy by using the lowdensity materials like ethylcellulose (5)Effervescent agent-This is the agents that produce carbon dioxide by contact with the acidic medium.in floating systems, the gas generating agent like citric acid, sodium bicarbonate are used [21]. …”

mentioning

confidence: 99%

Current Approaches on Gastroretentive Drug Delivery systems

Pund

Shendge

Pote

2020

J. Drug Delivery Ther.

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Over recent years, there have been many efforts to develop the absorption rate of medications and the therapeutic efficacy of oral dosage types. GRDDS for strengthen the pharmacological effects of drugs with a small uptake site, are unbalanced at pH greater than 7, are dissolved under acidic region, and are effective local region in the stomach. The gastro retentive systems that have the different evaluation parameter that according to the dosage forms. There are many criteria for the choosing of the drug used in the gastro-retardant systems as the drug should be sparingly stable, it should be compatible with the gastric region, and narrow absorption. In this review, we have summarized the information related to the various approaches for enhancing and prolonging of the dosage forms in the stomach for their extended-release of action. Also talking about the many natural and synthetic polymers is used in the formulation with their different grade and their ratio that affects on the release action. The many scientist and inventors have increased their interest in developing the novel dosage forms and they staying in the stomach for showing the prolonged period action. We have also discussed the novel technology are involved in the gastric retention many companies has been developed the polymer grades for using it in the formulation for showing the retention action. Keywords: Introduction, Approaches, Novel technologies, Polymer used in floating systems.

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Gastroretentive Drug Delivery Systems

Waknis,

Narang

2023

Oral Bioavailability and Drug Delivery

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Current State and Future Perspectives on Gastroretentive Drug Delivery Systems

Cited by 162 publications

References 104 publications

In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

Current Approaches on Gastroretentive Drug Delivery systems

Gastroretentive Drug Delivery Systems

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