Impact of supportive interventions on resilience and self-assessed psychopathology symptoms of 92 nurses in isolation ward during the COVID-19 pandemic was evaluated. Resilience and psychopathological symptoms of nurses in the isolation ward was assessed by Connor-Davidson Resilience Scale (CD-RISC) and the Symptom Checklist 90 (SCL-90). A total resilience score was 87.04 ± 22.78. The SCL-90 score was 160-to 281 (202.5 ± 40.79). Only 8.70% of the nurses (n = 8) had a total SCL-90 score >160, suggesting positive symptoms. The majority of nurses had 0 to 90 positive self-assessment items (median 14); 19.57% (n = 18) had > 43 positive items. Interpersonal sensitivity, depression, hostility, and paranoid ideation scores were below national averages (p=0.000, 0.040, 0.002, 0.004, respectively). SCL-90 items reflecting diet and sleep conditions were higher(P = 0.009), and somatization, obsessive-compulsive, anxiety, phobic anxiety, and psychoticism domains and scores were similar to national averages (P>0.3). With exception of somatization and other domains, the mean resilience score was negatively associated with the scores of other SCL-90 domains. High resilience promotes physical and mental health, and may be improved by training, psychological interventions and full use of hospital resources ARTICLE HISTORY