Current State-of-the-Art and New Trends in Self-Assembled Nanocarriers as Drug Delivery Systems

Abstract

Self-assembled nanocarrier drug delivery has received profuse attention in the field of diagnosis and treatment of diseases. These carriers have proved that serious life-threatening diseases can be eliminated evidently by virtue of their characteristic design and features. This review is aimed at systematically presenting the research and advances in the field of self-assembled nanocarriers such as polymeric nanoparticles, dendrimers, liposomes, inorganic nanocarriers, solid lipid nanoparticles, polymerosomes, micellar systems, niosomes, and some other nanoparticles. The self-assembled delivery of nanocarriers has been developed in recent years for targeting diseases. Some of the innovative attempts with regard to prolonging drug action, improving bioavailability, avoiding drug resistance, enhancing cellular uptake, and so on have been discussed. The discussion about various delivery systems included the investigation conducted at the preliminary stage, i.e., preclinical trials and assessment of safety. The clinical studies of some of the recently developed self-assembled products are currently at the clinical trial phase or FDA approved.

Dissolution Rate Enhancement of Dolutegravir Sodium Through Nanosuspension Technology Using 3 2 Factorial Design

“…It was discovered that the contour plot was multi-dimensional. Thus, there was a nonlinear connection between the independent factors and the particle size and saturation solubility as well [22].…”

Recent Pharmaceutical Developments in the Treatment of Cancer Using Nanosponges

“…Carbon nanosponges have high loading and can be filled with a high number of materials. And nanosponges do not behave to changes in temperature [108][109][110]. Korea Ceramic Technology Institute developed a thermosponge for the treatment of cancer.…”

Niosomes: Composition, Formulation Techniques, and Recent Progress as Delivery Systems in Cancer Therapy

“…Niosomes, the most recently developed vesicular system with an extraordinary range of applications, are bilayer structures formed by amphiphilic non-ionic surfactants and lipidic components (mostly cholesterol) [12][13][14][15]. They are more stable than liposomes and and lipidic components (mostly cholesterol) [12][13][14][15]. They are more stable than liposomes and have the ability to encapsulate hydrophilic and lipophilic molecules with biological activity (Figure 1).…”