Current states and future views in photodynamic therapy

Yano, Shigenobu; Hirohara, Shiho; Obata, Makoto; Hagiya, Yuichiro; Ogura, Shun‐ichiro; Ikeda, Atsushi; Kataoka, Hiromi; Tanaka, Mamoru; Joh, Takashi

doi:10.1016/j.jphotochemrev.2011.06.001

Cited by 500 publications

(403 citation statements)

References 170 publications

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“…The relative powers used for imaging or activation are directly related to the PS used. PDD might potentially be beneficial in the diagnosis of early stage cancers and real-time optimization of light delivery parameters could help to improve treatment outcomes [3,43,69]. For it to be clinically useful in detecting cancers, adjustment of the irradiation area is necessary and posttreatment PSs need to display sufficient fluorescence which can be difficult because of PS photobleaching caused by the high light dose irradiation during PDT [15,43].…”

Section: Photodynamic Diagnosis/detection (Pdd)mentioning

confidence: 99%

“…The evaluation of PICs in EGFR overexpressing mouse models of A431 squamous cell carcinoma cells in which irradiation leads to fluorescence and ROS generation causing lysosome proteolysis showed cell killing of individual micrometastases [141]. Yano et al 2011 proposed the addition of a sugar moiety to PSs to improve their targeting towards tumour cells which consume larger amounts of glucose than normal cells (Warburg effect) [3]. The preparation of a nonconjugated tumour targeted NIR imaging agent and PDT PS based on heptamethine dyes (IR-808) which shows efficient light induced cytotoxicity towards cancer cells has also been reported [145].…”

Section: Targeted Photosensitizer Deliverymentioning

confidence: 99%

“…PDT is such an alternative treatment modality, which on its own or in combination with the classical treatments aims to provide improved clinical outcomes and long term remission for cancer patients. The main advantages of clinically approved PDT include its minimal invasiveness (minimized scarring) compared with surgical tumour removal, reduced likelihood to develop multidrug resistance (MDR) and selectivity towards malignant cells restricting unwanted side-effects towards collateral healthy tissue compared with chemotherapy [3][4][5][6].…”

Section: Introduction To Pdtmentioning

confidence: 99%

“…This prolonged sensitivity to light usually forces the patient to avoid direct exposure to sunlight until the drug is discharged. Accurately specifying the dosimetry of PS administered and light dose can help to reduce this unwanted side-effect [3,10,[13][14][15]. Another major limitation of PDT is the depth the activating light can penetrate into tissue at the excitation wavelength [4,16], as well as the inactivity of many photosensitizers in hypoxic environments, which restricts formation of ROS, such as commonly found in tumour cores.…”

Section: Introduction To Pdtmentioning

confidence: 99%

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New Approaches to Photodynamic Therapy from Types I, II and III to Type IV Using One or More Photons

Scherer

Bisby²,

Botchway³

et al. 2017

ACAMC

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Photodynamic therapy (PDT) is an alternative cancer treatment to conventional surgery, radiotherapy and chemotherapy. It is based on activating a drug with light that triggers the generation of cytotoxic species that promote tumour cell killing. At present, PDT is mainly used in the treatment of wet age-related macular degeneration, for precancerous conditions of the skin (e.g. actinic keratosis) and in the palliative care of advanced cancers, for instance of the bladder or the oesophagus. Due to a lack of phase III clinical trials and limitations of light penetration to deeper lying tumours (in excess of 1 cm), PDT is still not used as a first line cancer treatment, which is surprising given the first clinical trials by Dougherty's group dating back to the 1970's. However research continues to demonstrate the potential benefits of PDT and the need to stimulate funding and uptake of clinical studies using next generation photosensitizers offering advanced targeted delivery, improved photodynamic dose combined with modern light delivery technologies. This review surveys the available PDT treatments and emerging novel developments in the field with a particular focus on two-photon techniques that are anticipated to improve the effectiveness of PDT in tissues at depth and on next generation drugs that work without the need of the presence of oxygen for photosensitization making them effective where hypoxia has taken hold.

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Section: Photodynamic Diagnosis/detection (Pdd)mentioning

confidence: 99%

Section: Targeted Photosensitizer Deliverymentioning

confidence: 99%

Section: Introduction To Pdtmentioning

confidence: 99%

Section: Introduction To Pdtmentioning

confidence: 99%

See 2 more Smart Citations

New Approaches to Photodynamic Therapy from Types I, II and III to Type IV Using One or More Photons

Scherer

Bisby²,

Botchway³

et al. 2017

ACAMC

View full text Add to dashboard Cite

show abstract

“…Photodynamic therapy (PDT) is a non-invasive method for the treatment of numerous diseases that has attracted interests in last decades [7,8]. In cancer treatments, photosensitizers (PS) that are excited by visible or UV light remove tumor cells by photocatalysis process [9].…”

Section: Introductionmentioning

confidence: 99%

Ultraviolet and Visible Upconversion Emissions in Er3+-Yb3+ Doped Titanium Dioxide Nanopowder under the 980 nm Laser Diode Excitation

2017

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Abstract. Er 3+ -Yb 3+ co-doped titanium dioxide upconversion nanoparticles were synthesized by sol-gel method. White upconversion emissions were observed after excitation of nanoparticles with 980 nm Near-Infrared laser diode. Upconversion emissions consist of red (640-690 nm), green (520-570 nm), and blue (408 nm) emissions. Ultraviolet upconversion emissions were also detected with wavelength about 210 nm. Ultraviolet emissions are probably the results of relaxation from 2 I 13=2 (220 nm) and 2 L 15=2 (210 nm) states to 4 I 15=2 . Visible and ultraviolet emissions of these nanoparticles can be used in photodynamic therapy. High penetration of Near-Infrared light into the body tissue makes these nanoparticles appropriate for aiming tumors in deeper tissues in comparison with older methods of photodynamic therapy.

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