Current states of prevention of drug-induced gastroduodenal ulcer in real clinical practice: a cross-sectional study

Iwamoto, Junichi; Murakami, Masashi; Monma, Tadakuni; Ueda, Hajime; Tamamushi, Makoto; Konishi, Naoki; Yara, Shoichiro; Hirayama, Takeshi; Ikegami, Tadashi; Honda, Akira; Mizokami, Yuji

doi:10.3164/jcbn.19-66

J. Clin. Biochem. Nutr.

2020

DOI: 10.3164/jcbn.19-66

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Current states of prevention of drug-induced gastroduodenal ulcer in real clinical practice: a cross-sectional study

Junichi Iwamoto

Masashi Murakami

Tadakuni Monma

et al.

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“…(1)(2)(3)(4)(5)(6)(7)(8) Upper GI bleeding can be induced by lesions of the esophagus, stomach, and duodenum, including gastroduodenal ulcers induced by Helicobacter pylori (H. pylori) infection, nonsteroidal anti-inflammatory drugs (NSAIDs), and antithrombotic agents; Mallory-Weiss tears; and gastroesophageal varices. (1,2,(9)(10)(11)(12) The Japan Medical Data Center (JMDC) claims database is a real-world database in Japan that has been available for research purposes since 2005. The JMDC consists of data for approximately 3.7 million people, including data from health insurance providers for company employees and their families.…”

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Decline incidence in upper gastrointestinal bleeding in several recent years: data of the Japan claims database of 13 million accumulated patients

Fujimoto

Tsuruoka

Esaki

et al. 2021

J. Clin. Biochem. Nutr.

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This study was to examine the recent trends in upper gastro intestinal bleeding in Japan using a large scale real world database. The incidence of upper gastrointestinal bleeding was evaluated in the Japan Medical Data Center claims database of 13,019,713 patients aged 20 to 74 years with traceability for 3 months from 2009 to 2014. The incidence was compared with peptic ulcers and gastroesophageal reflux disease. The prescrip tion of medications was also evaluated. The incidence of bleeding was 0.137%, 0.121%, 0.113%, 0.106%, 0.099%, and 0.105% during 2009 to 2014 with a time dependent decline (p<0.001). Peptic ulcers (>10 times higher than the incidence of bleeding) decreased with time (p<0.001), whereas gastroesophageal reflux disease increased (p = 0.006). Upper gastrointestinal bleeding was higher in male patients and older patients (60-74 years old) (p<0.001 respectively). The prescription rate of antithrombotic medications and proton pump inhibitors increased from 2009 to 2014 (p<0.001 respectively). The incidence of upper gastrointestinal bleeding decreased from 2009 to 2014 in this relatively large scale real world database in Japan, concomitant with the decrease in peptic ulcers. The decreased incidence might have been due to changes in the disease structure and therapeutic strategies over time.

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confidence: 99%

Decline incidence in upper gastrointestinal bleeding in several recent years: data of the Japan claims database of 13 million accumulated patients

Fujimoto

Tsuruoka

Esaki

et al. 2021

J. Clin. Biochem. Nutr.

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Current states of prevention of drug-induced gastroduodenal ulcer in real clinical practice: a cross-sectional study

Cited by 1 publication

References 20 publications

Decline incidence in upper gastrointestinal bleeding in several recent years: data of the Japan claims database of 13 million accumulated patients

Decline incidence in upper gastrointestinal bleeding in several recent years: data of the Japan claims database of 13 million accumulated patients

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