Current statistical issues in clinical cancer research

Altman, D G; Machin, David

doi:10.1038/bjc.1993.368

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Diagnostic Performance Evaluation1

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Cited by 4 publications

(2 citation statements)

References 16 publications

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“…These differences were quantified using the j indices (observed agreements against chance-expected agreement by chance), which are 0.84 and 1.00 for TcP2b-MBP and TcP2b-TRX, respectively. These values corresponded to very good and total agreement, respectively [23]. Dispersion results for the different assays are shown in Fig.…”

Section: Diagnostic Performance Evaluationsupporting

confidence: 53%

The diagnostic performance of recombinant Trypanosoma cruzi ribosomal P2β protein is influenced by its expression system

Marcipar

Olivares

Robles

et al. 2004

Protein Expression and Purification

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Section: Diagnostic Performance Evaluationsupporting

confidence: 53%

The diagnostic performance of recombinant Trypanosoma cruzi ribosomal P2β protein is influenced by its expression system

Marcipar

Olivares

Robles

et al. 2004

Protein Expression and Purification

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“…The U index indicates concordance between the ELISA test using LLGP-67 as antigen and the reference criterion that was used for characterization of sera. It is interesting to remark that U values between 0.91 and 1 are considered highly concordant [22].…”

Section: Discussionmentioning

confidence: 99%

Purification of the 67-kDa lectin-like glycoprotein ofTrypanosoma cruzi, LLGP-67, and its evaluation as a relevant antigen for the diagnosis of human infection

Marcipar

Welchen

Roodveldt

et al. 2003

FEMS Microbiology Letters

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In the present work we propose a simple method for affinity purification of the 67-kDa lectin-like glycoprotein (LLGP-67) from Trypanosoma cruzi, the causative agent of Chagas' disease. The LLGP-67, which presents galactose binding activity and participates in the host cell recognition process, was previously purified by methods based on its interaction with galactose residues on erythrocytic membranes. We describe herein results showing that this protein can be purified from T. cruzi in a direct way using non-derivatized agarose as a chromatographic ligand. We also demonstrate the relevance of LLGP-67 as an antigen for human diagnosis of chagasic infection. Sensitivity and specificity for this antigen were calculated, being 98 and 98.11% respectively.

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Uso y accesibilidad del análisis estadístico en la revista Archivos De Bronconeumología (1970–1999)

Orive

Jiménez

Sacristán

et al. 2002

Archivos de Bronconeumología

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Current statistical issues in clinical cancer research

Cited by 4 publications

References 16 publications

The diagnostic performance of recombinant Trypanosoma cruzi ribosomal P2β protein is influenced by its expression system

The diagnostic performance of recombinant Trypanosoma cruzi ribosomal P2β protein is influenced by its expression system

Purification of the 67-kDa lectin-like glycoprotein ofTrypanosoma cruzi, LLGP-67, and its evaluation as a relevant antigen for the diagnosis of human infection

Uso y accesibilidad del análisis estadístico en la revista Archivos De Bronconeumología (1970–1999)

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