Current status and characteristics of atopic dermatitis in Korea

Kim, Kyu Han

doi:10.5124/jkma.2014.57.3.208

Cited by 6 publications

(5 citation statements)

References 17 publications

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“…The prevalence of AD in this study was 6.8% which is similar to the previous findings [3]. However, we found no significant differences in the prevalence of AD of between middle school students and high school students, which is not consistent with other findings that the prevalence of AD decreases with age [40–43].…”

Section: Discussionsupporting

confidence: 57%

“…The worldwide prevalence of AD is 10%-20%, and it has significantly increased during the last three decades [2]. In Korea, its prevalence is estimated to be about 10% in the pediatric population less than 6 years of age and about 3% among adults [3]. In the Eighth Korean Youth Risk Behavior Survey (KYRBS), a nation-wide web-based survey, conducted by the Korea Centers for Disease Control and Prevention in 2012, 24% of adolescents responded that they had ever been diagnosed with AD [4].…”

Section: Introductionmentioning

confidence: 99%

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Association of atopic dermatitis with depressive symptoms and suicidal behaviors among adolescents in Korea: the 2013 Korean Youth Risk Behavior Survey

Lee

Shin

2017

BMC Psychiatry

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BackgroundAtopic dermatitis (AD) is a chronic skin disease which has been known to negatively influence the mental health of patients. However, only a few studies have explored the prevalence of psychiatric problems among AD patients, particularly among adolescents. In this study, we aimed to assess the association of AD with depressive symptoms and suicidal behaviors among adolescents by analyzing data from the 2013 Korean Youth Risk Behavior Survey, a nationwide web-based survey.MethodsData from 72,435 adolescent middle and high school students in Korea were analyzed. Students self-reported AD diagnosed by a doctor and yes-or-no answers to questions about depressive symptoms and suicide ideation, suicide planning, and suicide attempts were analyzed. Relationships between AD and depressive symptoms or suicidal behaviors were tested by logistic regression models after controlling for potential confounding factors.ResultsThe proportion of adolescents who had AD was 6.8%. The proportion of adolescents reporting depressive feelings was 31.0%, suicide ideation was 16.3%, suicide planning was 5.8%, and suicide attempts was 4.2%. Compared to adolescents without AD, adolescents with AD were significantly more likely to experience depressive feelings (odds ratio [OR]: 1.27, 95% confidence interval [Cl]: 1.19-1.36), suicide ideation (OR: 1.34, 95% Cl: 1.24-1.45), suicide planning (OR: 1.46, 95% Cl: 1.32-1.65), and suicide attempts (OR: 1.51, 95% Cl: 1.33-1.72). In the multivariate model, the relationships between AD and suicide ideation (OR: 1.26, 95% Cl:1.16-1.36), suicide planning (OR: 1.28, 95% Cl:1.14-1.44), and suicide attempt (OR: 1.29, 95% Cl:1.13-1.49) were statistically significant.ConclusionAdolescents who have AD are associated with a higher prevalence of depression symptoms and suicidal behaviors. Adolescent AD patients may need interventions from clinicians and caregivers that use a holistic approach to prevent psychological comorbidities, although further research is needed to clarify this relationship.

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Association of atopic dermatitis with depressive symptoms and suicidal behaviors among adolescents in Korea: the 2013 Korean Youth Risk Behavior Survey

Lee

Shin

2017

BMC Psychiatry

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“…Food intakes of the subjects according to ADThe p-value were estimated by t-test in complex sample survey data analysis 2). Age and sex adjusted.나 RNI의 125% 초과 섭취율은 각각 −3.6%와 −3.1%로 유의적으로 낮았다 (p = 0.010).…”

mentioning

confidence: 99%

“…Nutrient intakes of the subjects according to ADThe p-value were estimated by t-test in complex sample survey data analysis 2). Age and sex adjusted.…”

mentioning

confidence: 99%

Evaluation of nutritional status and adequacy of energy and nutrient intakes among atopic dermatitis children under 12 years of age: based on Korea National Health and Nutrition Examination Survey data (2013–2015)

김

2020

J Nutr Health

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Purpose: Atopic dermatitis (AD), a typical chronic disease in children, is an allergy disease that is highly associated with food. Thus, attention to food intake is needed to prevent and manage it. Therefore, we analyzed differences in food and nutrient intakes depending on AD status in under 12-year-old children. Methods: A total of 2,690 participants were enrolled in this study from the combined 2013-2015 Korea National Health and Nutrition Examination Survey. Subjects were divided into an AD group and normal group (non-AD group). General characteristic, food and nutrients intakes, and prevalence of insufficient and excessive nutrient intake were analyzed using χ 2 test and regression analyses. The AD odds ratio (OR) for insufficient and excessive nutrient intakes was analyzed using multiple logistic regression analyses. Results: Food and nutrient intakes were not significantly different between the AD and non-AD groups. However, the ratio of calcium intake to recommended nutrient intake was about

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“…Atopic dermatitis (AD) is an inflammatory skin disease that is approximately 7% in the adults in the USA, and the prevalence of adult‐onset AD is lower than that of child‐onset AD (Vakharia & Silverberg, 2019). Similarly, the prevalence of AD among Korean children (<6 years old) is about 10%, and in adults, around 3% in Korea (Kim, 2014). The pathophysiology of AD is not entirely understood.…”

Section: Introductionmentioning

confidence: 99%

Pinus koraiensis needle or cone extracts alleviate atopic dermatitis symptoms by regulating immunity and suppressing inflammation in HaCaT cells and Nc/Nga mice

Ryuk

Moon

et al. 2022

Journal of Food Biochemistry

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Pinus koraiensis needles (PKN) and cones (PKC) have been shown to protect against inflammation and pathogenic bacteria. We investigated the efficacies and action mechanisms of topical applications of 1,3-butylene glycol (BG) extracts and oral administration of their water extracts on atopic dermatitis (AD) symptoms. After exposing HaCaT cells and Nc/Nga mice dorsal skins to 2,4-dinitrochlorobenzene (DNCB) to induce atopic dermatitis models, they were topically applied BG (AD-control), 30% PKNX, or 30% PKCX to the skin lesions and fed water extracts (0.5%) in high-fat diets for 5 weeks. Normal-control mice had no DNCB exposure. Serum immunoglobulin E (IgE), IL-4, and TNFα levels and gene expressions of TNFα, IL-4, IL-6, and IFNγ in the dorsal skin and HaCaT cells were measured. The AD-control mice elevated TNFα and IL-6 mRNA levels in HaCaT cells. Both extracts attenuated clinical AD symptoms in AD-induced Nc/Nga mice: PKNX improved hemorrhage, erythema, and lichenification of dorsal skin better than PKCX while both similarly alleviated erythema, edema, excoriation, and itching behavior. PKCX reduced IgE contents and increased filaggrin mRNA expression better than PKNX, but PKNX reduced lipid peroxides and mRNA levels of TNFα and IL-4 in the dorsal skin. In the histological analysis of the dorsal skin, the administration of both extracts significantly decreased mast cell numbers, immune cell infiltration, gaps between the epidermis and dermis, and abnormal cell and nucleus shapes. In conclusion, both PKCX and PKNX treatment alleviated the DNCB-induced clinical symptoms of AD by alleviating immune-related symptoms and inflammation in partially different pathways. Therefore, PKNX and PKCX may be effective for AD therapy. Practical applicationsAtopic dermatitis (AD) is related to an overly activated immune response, and it has steadily increased last 3 decades. However, no optimal sustainable treatments are available. Pinus koraiensis needles and cones extracts have been used for antiinflammatory and antimicrobial treatment. The present study demonstrated that their intake and topical administration onto the AD lesion alleviated clinical AD symptoms associated with reduced proinflammatory cytokines, mast cell numbers, and immune cell infiltrates to maintain dermal structure with maintaining filaggrin expression in How to cite this article:

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Current status and characteristics of atopic dermatitis in Korea

Cited by 6 publications

References 17 publications

Association of atopic dermatitis with depressive symptoms and suicidal behaviors among adolescents in Korea: the 2013 Korean Youth Risk Behavior Survey

Association of atopic dermatitis with depressive symptoms and suicidal behaviors among adolescents in Korea: the 2013 Korean Youth Risk Behavior Survey

Evaluation of nutritional status and adequacy of energy and nutrient intakes among atopic dermatitis children under 12 years of age: based on Korea National Health and Nutrition Examination Survey data (2013–2015)

Pinus koraiensis needle or cone extracts alleviate atopic dermatitis symptoms by regulating immunity and suppressing inflammation in HaCaT cells and Nc/Nga mice

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