Current Status and Future Direction of PET/MR in Cardiology

Masuda, Atsuro; Takeishi, Yasuchika

doi:10.17996/anc.17-00018

Cited by 4 publications

(1 citation statement)

References 41 publications

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“…The modules are highly advantageous when small size is paramount. There is a growing recognition of the benefits of simultaneous PET/MRI for molecular imaging [34] such as oncology [39], quality assurance in hadron therapy [40], cerebral blood flow [41], cardiac PET/MRI [42], and brain functions [43]. Those systems will be beneficial to pediatric patients in particular, given the large reduction in radiation dose compared with PET/CT [32,33].…”

Section: Discussionmentioning

confidence: 99%

Medical Electronics

2020

Advancing Microelectronics Magazine

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Recent advancement of flexible wearable electronics allows significant enhancement of portable, continuous health monitoring and persistent human-machine interfaces. Enabled by flexible electronic systems, smart and connected bioelectronics are accelerating the integration of innovative information science and engineering strategies, ultimately driving the rapid transformation of healthcare and medicine. Recent progress in development and engineering of soft materials has provided various opportunities to design different types of mechanically deformable systems towards smart and connected bioelectronics. Here, we summarize the key properties of soft materials and their characteristics in the context of wearable sensors and electronics. Details of functionality and sensitivity of the bioelectronics are discussed with applications in health, medicine, and machine interfaces. In addition, we introduce recent examples of bioelectronics that offer persistent human-machine interfaces to control prosthetic hands, wheelchairs, or computer interfaces.

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Section: Discussionmentioning

confidence: 99%

Medical Electronics

2020

Advancing Microelectronics Magazine

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Direct comparisons of left ventricular volume and function by simultaneous cardiac magnetic resonance imaging and gated 13N-ammonia positron emission tomography

Kiko

Yoshihisa

Yokokawa

et al. 2020

Nuclear Medicine Communications

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Objectives Hybrid PET/MRI is useful for the simultaneous evaluation of both 13 N-ammonia PET and MRI data. The aim of the current study was to compare the accuracy of gated 13 N-ammonia PET with MRI for the measurement of left ventricular volumes and function in patients with coronary artery disease (CAD), using simultaneous acquisitions on a hybrid PET/MRI system. Methods Fifty-one consecutive patients with suspected CAD who underwent 13 N-ammonia PET/MRI were enrolled in this study. End-diastolic volume (EDV), end-systolic volume (ESV), and left ventricular ejection fraction (LVEF) were simultaneously evaluated using both gated 13 N-ammonia PET and cine MRI. Regional wall motion was visually scored on a 4-point scale using a 17-segment model for both methods. Results The correlations between each EDV (R = 0.99, P < 0.001), ESV (R = 0.98, P < 0.001), and LVEF (R = 0.99, P = 0.001) measured by gated 13 N-ammmonia and MRI were very high. These high correlations were also observed in postmyocardial infarction patients. Furthermore, the regional wall motion scores determined on gated 13 N-ammonia PET and MRI showed an agreement of 89.0% with a kappa value of 0.82 ± 0.02. Conclusion EDV, ESV, LVEF, and regional wall motion measured by gated 13 N-ammonia PET were highly correlated with those measured by MRI.

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Utility of Updated Japanese Circulation Society Guidelines to Diagnose Isolated Cardiac Sarcoidosis

Sato

Kawamatsu

Yamamoto

et al. 2022

JAHA

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Background In the population with cardiac sarcoidosis (CS), approximately one third lacks extracardiac involvement and is considered to have isolated CS. Recently, the Japanese Circulation Society updated the diagnostic criteria for CS, providing a methodology for diagnosing isolated CS. We aimed to assess the characteristics of isolated CS diagnosed using a multimodal imaging approach according to the updated Japanese Circulation Society guidelines. Methods and Results We retrospectively identified 161 consecutive patients who underwent 18F‐fluorodeoxyglucose positron emission tomography for suspected CS between 2012 and 2019. According to the guidelines, patients were classified as having CS with extracardiac involvement, isolated CS, or no CS. We compared the characteristics of multimodality imaging and the prevalence of major adverse cardiovascular events. The Japanese Circulation Society criteria classified 28 patients (17%) as having CS with 4 (2%) with histological confirmation, 21 (13%) as isolated CS, and 112 (70%) as no CS. Compared with CS, isolated CS showed higher left ventricular volume and reduced left ventricular ejection fraction ( P <0.01 for all). During the median follow‐up period of 522 days, 24 patients had major adverse cardiovascular events. Isolated CS (hazard ratio, 3.35; [95% CI, 1.08–10.39], P =0.036) was independently associated with major adverse cardiovascular events after adjusting for reduced left ventricular ejection fraction and steroid. In the subgroup of 41 patients with serial 18F‐fluorodeoxyglucose positron emission tomography evaluation, only updated CS criteria were associated with improvement in myocardial inflammation on 18F‐fluorodeoxyglucose positron emission tomography. Conclusions Isolated CS detected using the updated Japanese Circulation Society guidelines was associated with poor event‐free survival and should be managed with caution.

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Current Status and Future Direction of PET/MR in Cardiology

Cited by 4 publications

References 41 publications

Medical Electronics

Medical Electronics

Direct comparisons of left ventricular volume and function by simultaneous cardiac magnetic resonance imaging and gated 13N-ammonia positron emission tomography

Utility of Updated Japanese Circulation Society Guidelines to Diagnose Isolated Cardiac Sarcoidosis

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