Current Status and Future Directions in Appendiceal Cancer with Peritoneal Dissemination

Votanopoulos, Konstantinos I.; Shen, Perry; Stewart, John H.; Levine, Edward A.

doi:10.1016/j.soc.2012.07.012

Cited by 10 publications

(10 citation statements)

References 43 publications

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“…PMP is a diagnostically challenging disease with poor response to chemotherapy and frequent recurrences [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Ovarian involvement is usually secondary. Table 2 Classification of appendiceal mucinous neoplasms and pseudomyxoma peritonei [6] Ronnett et al [3] AJCC and WHO [6] Tumor confined to appendix [6][7][8][9]. It is currently classified as mucinous adenocarcinoma: low grade and high grade (WHO and AJCC 2010) [6] (Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…2. Completeness of cytoreduction (CCR) score [7,8], i.e., removal of all gross disease, as assessed by Chua et al study [15]. When no residual disease remained, the CCR score was 0.…”

Section: Discussionmentioning

confidence: 99%

“…Surgical debulking remains the main stay of treatment with role of hyperthermic intraperitoneal chemotherapy (HIPEC) being assessed in terms of morbidity, mortality, efficacy and long-term survival [7,8,16,17].…”

Section: Discussionmentioning

confidence: 99%

“…This can be further classified as invasive, low grade or high grade, based on the WHO AJCC 2010 classification [6]. The treatment options range from cytoreductive surgery to hyperthermic intraperitoneal chemotherapy (HIPEC) with varied prognosis [7,8].…”

Section: Introductionmentioning

confidence: 99%

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“The Jelly Belly”: Diagnostic Dilemmas and Current Concepts

Kedia

Ravikumar

Mohanty

et al. 2016

J Obstet Gynecol India

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Background Pseudomyxoma peritonei (PMP) is a rare and poorly understood clinicopathological entity characterized by gelatinous ascites with neoplastic or non-neoplastic mucinous implants in the peritoneum. Although its origin was debated, current evidence in literature favours the appendix as the origin of the disease, over the ovaries. The changing terminologies in the classification of this entity pose diagnostic and management challenges. Case Reports Herein, we report three cases of PMP in postmenopausal women, their clinical presentation, pathological staging based on the peritoneal tumor deposits and the treatment administered. Two patients recovered uneventfully, while one had recurrence of adenocarcinoma. Conclusion The rarity of this disease and the diagnostic challenges associated with it are discussed with an emphasis on the current concepts in its origin and management. Appropriate classification and complete removal of the tumor is mandated to prevent disease-related mortality.

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“…PMP is a diagnostically challenging disease with poor response to chemotherapy and frequent recurrences [7,8].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…2. Completeness of cytoreduction (CCR) score [7,8], i.e., removal of all gross disease, as assessed by Chua et al study [15]. When no residual disease remained, the CCR score was 0.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

“The Jelly Belly”: Diagnostic Dilemmas and Current Concepts

Kedia

Ravikumar

Mohanty

et al. 2016

J Obstet Gynecol India

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Main Topics of Discussion and New Trends

Giorgio

2015

Treatment of Peritoneal Surface Malignancies

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Recommendations in the management of epithelial appendiceal neoplasms and peritoneal dissemination from mucinous tumours (pseudomyxoma peritonei)

et al. 2015

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The epithelial appendiceal neoplasms are uncommon and are usually detected as an unexpected surgical finding. The general surgeon should be aware of the diversity of its clinical manifestations and biological behaviors along with the significance of the surgical treatment on the progression of the illness and the prognosis of the patients. The operative findings and, especially, tumor histology, determine the type of surgery. Intestinal histologic subtype behaves and should be treated similarly to the right colon neoplasms; while mucinous tumors, often discordant between histology and its aggressiveness, can be treated with a simple appendectomy or require complex oncological surgeries. Mucinous tumors are often associated with the presence of mucin or tumor implants in the abdominal cavity, being the clinical syndrome known as pseudomyxoma peritonei (PMP). PMP tends to present an indolent but deadly evolution and requires a multimodal approach as a single treatment with curative potential: complete cytoreductive surgery plus hyperthermic Intra-peritoneal chemotherapy (CCRS + HIPEC) now considered the standard of care in this pathology. The general surgeon should be aware of the governing principles of the treatment of appendiceal neoplasms with or without peritoneal dissemination, know the therapeutic frontiers in every situation (avoiding unnecessary or counterproductive surgeries) and sending early these patients to specialised centres in the radical management of malignant diseases of the peritoneum in the conditions and with the necessary information to facilitate a possible radical treatment.

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Current Status and Future Directions in Appendiceal Cancer with Peritoneal Dissemination

Cited by 10 publications

References 43 publications

“The Jelly Belly”: Diagnostic Dilemmas and Current Concepts

“The Jelly Belly”: Diagnostic Dilemmas and Current Concepts

Main Topics of Discussion and New Trends

Recommendations in the management of epithelial appendiceal neoplasms and peritoneal dissemination from mucinous tumours (pseudomyxoma peritonei)

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