Current status and progress in immunotherapy for malignant pleural mesothelioma

Sun, Boyang; Dong, Yingyue; Xu, Jiachen; Wang, Zhijie

doi:10.1002/cdt3.18

Cited by 3 publications

(4 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2020, a combination of anti-PD-1 mAb nivolumab plus anti-CTLA-4 mAb ipilimumab was approved by the U.S. Food and Drug Administration (FDA) as a first-line therapy for unresectable MPM (7,15,16). Whereas initial promising results of mAb-based therapy have changed the landscape of MPM treatment, the efficacy is limited to a certain subset of patients, indicating an urgent need to establish biomarkers for patient selection (17)(18)(19)(20)(21)(22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

Three distinct mechanisms underlying human γδ T cell-mediated cytotoxicity against malignant pleural mesothelioma

et al. 2023

View full text Add to dashboard Cite

IntroductionMalignant pleural mesothelioma (MPM) is a rare and highly aggressive thoracic tumor with poor prognosis and limited therapeutic options. Although immune checkpoint inhibitors exhibit a promising effect in some patients with unresectable MPM in clinical trials, the majority of MPM patients show only modest response rates to the currently available treatments. It is thus imperative to develop novel and innovative therapeutic modalities for MPM, including immune effector cell-based therapies.Methodsγδ T cells were expanded using tetrakis-pivaloyloxymethyl 2-(thiazole-2-ylamino) ethylidene-1,1-bisphosphonate (PTA) and interleukin-2, and the therapeutic potential of γδ T cells was examined through analyzing cell surface markers and cellular cytotoxicity against MPM in vitro using a europium chelate-based time-resolved fluorescence assay system and a luciferase-based luminescence assay system.Results and discussionWe successfully expanded γδ T cells from peripheral blood mononuclear cells of healthy donors and MPM patients. γδ T cells expressed natural killer receptors such as NKG2D and DNAM-1 and exhibited a moderate level of cytotoxicity to MPM cells in the absence of antigens. The inclusion of PTA, (E)-4-hydroxy-3- methylbut-2-enyl diphosphate (HMBPP) or zoledronic acid (ZOL) induced a TCR-dependent cytotoxicity in γδ T cells and secreted interferon-γ (IFN-γ). In addition, γδ T cells expressing CD16 exhibited a significant level of cytotoxicity against MPM cells in the presence of an anti-epidermal growth factor receptor (EGFR) mAb, at lower concentrations than in clinical settings, whereas a detectable level of IFN-γ was not produced. Taken together, γδ T cells showed cytotoxic activity against MPM in three distinct mechanisms through NK receptors, TCRs and CD16. Since major histocompatibility complex (MHC) molecules are not involved in the recognition, both autologous and allogeneic γδ T cells could be used for the development of γδ T cell-based adoptive immunotherapy for MPM.

show abstract

Section: Discussionmentioning

confidence: 99%

Three distinct mechanisms underlying human γδ T cell-mediated cytotoxicity against malignant pleural mesothelioma

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Unfortunately, there are limited clinical treatment options available for this disease. One promising option is a combination therapy involving pemetrexed and cisplatin, which has been shown to improve response rate, overall survival, and quality of life in mesothelioma patients [ 125 ]. However, it is essential to note that many patients treated with this therapy experience tumor progression or recurrence within a year [ 125 ].…”

Section: Application Strategies Of Natural Anticancer Peptides and Pr...mentioning

confidence: 99%

“…One promising option is a combination therapy involving pemetrexed and cisplatin, which has been shown to improve response rate, overall survival, and quality of life in mesothelioma patients [ 125 ]. However, it is essential to note that many patients treated with this therapy experience tumor progression or recurrence within a year [ 125 ]. Recent studies have shown that a sialic acid-binding lectin isolated from Rana catesbeiana oocytes has the potential as an anticancer agent.…”

Section: Application Strategies Of Natural Anticancer Peptides and Pr...mentioning

confidence: 99%

Amphibian-Derived Natural Anticancer Peptides and Proteins: Mechanism of Action, Application Strategies, and Prospects

Chen,

Wu,

et al. 2023

IJMS

View full text Add to dashboard Cite

Cancer is one of the major diseases that seriously threaten human life. Traditional anticancer therapies have achieved remarkable efficacy but have also some unavoidable side effects. Therefore, more and more research focuses on highly effective and less-toxic anticancer substances of natural origin. Amphibian skin is rich in active substances such as biogenic amines, alkaloids, alcohols, esters, peptides, and proteins, which play a role in various aspects such as anti-inflammatory, immunomodulatory, and anticancer functions, and are one of the critical sources of anticancer substances. Currently, a range of natural anticancer substances are known from various amphibians. This paper aims to review the physicochemical properties, anticancer mechanisms, and potential applications of these peptides and proteins to advance the identification and therapeutic use of natural anticancer agents.

show abstract

“…Cisplatin was the first metal-based chemotherapeutic drug approved by Food and Drug Administration (FDA) in 1978 [ 1 , 2 , 3 ] and even today it is administered alone or in combination with radiotherapy or other antineoplastic agents for the treatment of several cancers, such as testicular [ 4 ], ovarian [ 5 ], lung [ 6 ], esophageal [ 7 ], stomach [ 8 ], prostate [ 9 ], cervical [ 10 ], colorectal cancers [ 11 ], head–neck carcinoma [ 12 ], non-Hodgkin lymphoma [ 13 ], multiple myeloma [ 14 ], melanoma [ 15 ] and mesothelioma [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Modulation of Transcription Profile Induced by Antiproliferative Thiosemicarbazone Metal Complexes in U937 Cancer Cells

et al. 2023

View full text Add to dashboard Cite

Since the discovery of cisplatin, the search for metal-based compounds with therapeutic potential has been a challenge for the scientific community. In this landscape, thiosemicarbazones and their metal derivatives represent a good starting point for the development of anticancer agents with high selectivity and low toxicity. Here, we focused on the action mechanism of three metal thiosemicarbazones [Ni(tcitr)2], [Pt(tcitr)2], and [Cu(tcitr)2], derived from citronellal. The complexes were already synthesized, characterized, and screened for their antiproliferative activity against different cancer cells and for genotoxic/mutagenic potential. In this work, we deepened the understanding of their molecular action mechanism using an in vitro model of a leukemia cell line (U937) and an approach of transcriptional expression profile analysis. U937 cells showed a significant sensitivity to the tested molecules. To better understand DNA damage induced by our complexes, the modulation of a panel of genes involved in the DNA damage response pathway was evaluated. We analyzed whether our compounds affected cell cycle progression to determine a possible correlation between proliferation inhibition and cell cycle arrest. Our results demonstrate that metal complexes target different cellular processes and could be promising candidates in the design of antiproliferative thiosemicarbazones, although their overall molecular mechanism is still to be understood.

show abstract

Current status and progress in immunotherapy for malignant pleural mesothelioma

Cited by 3 publications

References 55 publications

Three distinct mechanisms underlying human γδ T cell-mediated cytotoxicity against malignant pleural mesothelioma

Three distinct mechanisms underlying human γδ T cell-mediated cytotoxicity against malignant pleural mesothelioma

Amphibian-Derived Natural Anticancer Peptides and Proteins: Mechanism of Action, Application Strategies, and Prospects

Modulation of Transcription Profile Induced by Antiproliferative Thiosemicarbazone Metal Complexes in U937 Cancer Cells

Contact Info

Product

Resources

About