Current Status in the Treatment of Orbital Myositis

Mombaerts, Ilse; Koornneef, L.

doi:10.1016/s0161-6420(97)30301-7

Cited by 130 publications

(94 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the possibility of atypical myositis should be addressed because approximately half of the cases of orbital myositis may not have any tendon involvement. 26,27 A routine TFT might be recommended in euthyroid TAO. Kazuo et al 3 reported 7 patients among 35 with euthyroid TAO whose TRAb was over 5000%.…”

Section: Discussionmentioning

confidence: 99%

Clinical features of thyroid-associated ophthalmopathy in clinically euthyroid Korean patients

Jang

Lee

et al. 2012

Eye

View full text Add to dashboard Cite

Aim To compare clinical characteristics and thyroid-stimulating hormone receptor antibodies (TRAbs) in thyroid-associated ophthalmopathy (TAO) in euthyroid Korean patients with those in hyperthyroid patients. Methods Clinical activity scores (CASs), modified NOSPECS scores, exophthalmometry values, prevalence of optic neuropathy, restrictive myopathy and lid retraction, and the positivity and levels of TRAb (thyrotropin-binding inhibitor immunoglobulin (TBII) and thyroidstimulating immunoglobulin (TSI)) were compared in 24 euthyroid (group A) and 139 clinical/subclinical hyperthyroid TAO patients (group B). Results Group A presented more clinically unilateral involvement than group B (79.2% vs 27.3%, Po0.001), less active (CAS 1.50 vs 2.26, P ¼ 0.014) and less severe clinical course (NOSPECS 3.38 vs 4.13, P ¼ 0.037). Lid retraction was more prevalent in group A than group B (91.7% vs 66.2%, P ¼ 0.014). Prevalence of optic neuropathy and restrictive myopathy, and the mean value of exophthalmometry were not different. Mean TBII levels were lower (7.20 IU/l) in group A than in group B (44.58 IU/l, Po0.001). A similar difference was found in the TSI bioassay (201.40% vs 425.19%, P ¼ 0.001). The positive rate of TBII in group A (34.8%) was significantly lower than in group B (90.8%, Po0.001). The positive rate of TSI was high in both group A (83.3%) and B (91.7%), with no significant difference (P ¼ 0.337).Conclusions Patients with euthyroid TAO showed a less active and severe clinical course, more unilateral involvement, and lower levels of TRAb than those in patients with hyperthyroid TAO. These distinct clinical and biochemical characteristics might be useful in assessment of euthyroid TAO, and the TSI might be more sensitive for diagnosing these patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical features of thyroid-associated ophthalmopathy in clinically euthyroid Korean patients

Jang

Lee

et al. 2012

Eye

View full text Add to dashboard Cite

show abstract

“…Superior, lateral, and medial rectus muscles are involved equally frequently, and recurrences occur in Յ56% of cases. 7 Multiple muscle involvement, male sex, eyelid retraction, lack of protoptosis, and lack of response to systemic corticosteroids are associated with recurrent orbital myositis. 8 Thyroid function must be assessed in recurrent orbital myositis, and a familial incidence is possible.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Orbital Myositis Mimicking Sixth Nerve Palsy: Diagnosis with MR Imaging

Fischer¹,

Kempkes²,

Haage³

et al. 2009

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

SUMMARY:We present a case with recurrent orbital myositis sequentially affecting both lateral rectus muscles separately. In the first episode, the absence of the required symptoms for the diagnosis of orbital myositis led to the erroneous diagnosis of sixth nerve palsy. Eventually, the correct diagnosis was established with cerebral MR imaging. Orbital myositis should be included in the differential diagnosis of what appears clinically to be abducens palsy, and MR imaging with a focus on the orbita is mandatory in such patients.

show abstract

“…Up to 80% of patients treated with steroids alone eventually experience relapse of myositis during steroid taper and thus steroid-sparing medications are often necessary [4,5]. This rate is lower in patients presenting with single muscle disease [6].…”

Section: Orbital Myositismentioning

confidence: 99%

“…Among biologic agents, infliximab, daclizumab, rituximab, and adalimumab have all shown efficacy in isolated cases of orbital myositis [7][8][9][10][11]. Radiation therapy has also been utilized in treating orbital myositis, and although a good initial response was noted, long-term control of recurrences was noted to be suboptimal [4]. Treatment failures and chronic relapsing disease may warrant a biopsy [6].…”

Section: Orbital Myositismentioning

confidence: 99%