“…Bilateral adrenalectomy in cases of hepatic cirrhosis with intractable ascites may be followed by relief of oedema (Marson, 1954;Giuseffi et al, 1957 ;Henley et al, 1960). On the other hand, oedema is not produced by excessive aldosterone secretion alone, as in Cohn's syndrome, or by continued administration of large amounts to healthy subjects (August et al, 1958a(August et al, , 1958bLieberman, 1958). In many early cases of congestive cardiac failure with oedema aldosterone secretion is not significantly increased (Laragh, 1962b).…”